2005
DOI: 10.1007/s00335-004-2451-8
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Gene expression differences in mice divergently selected for methamphetamine sensitivity

Abstract: In an effort to identify genes that may be important for drug-abuse liability, we mapped behavioral quantitative trait loci (bQTL) for sensitivity to the locomotor stimulant effect of methamphetamine (MA) using two mouse lines that were selectively bred for high MA-induced activity (HMACT) or low MA-induced activity (LMACT). We then examined gene expression differences between these lines in the nucleus accumbens, using 20 U74Av2 Affymetrix microarrays and quantitative polymerase chain reaction (qPCR). Express… Show more

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Cited by 82 publications
(109 citation statements)
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“…To our knowledge, the only selected lines that have been used to map an amphetamine-related trait are the HMACT and LMACT lines, bred for high and low sensitivity to the acute stimulant effects of methamphetamine. QTL analyses using DNA from mice of these lines provided evidence that there are genes that influence sensitivity to methamphetamine on chromosomes 5, 9, 11, 12, and 15 (Palmer et al, 2005). In an attempt to align possible differences in gene expression with genes that reside within these QTL regions, nucleus accumbens tissue from the HMACT and LMACT lines was used in a microarray gene expression analysis.…”
Section: Selected Linesmentioning
confidence: 99%
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“…To our knowledge, the only selected lines that have been used to map an amphetamine-related trait are the HMACT and LMACT lines, bred for high and low sensitivity to the acute stimulant effects of methamphetamine. QTL analyses using DNA from mice of these lines provided evidence that there are genes that influence sensitivity to methamphetamine on chromosomes 5, 9, 11, 12, and 15 (Palmer et al, 2005). In an attempt to align possible differences in gene expression with genes that reside within these QTL regions, nucleus accumbens tissue from the HMACT and LMACT lines was used in a microarray gene expression analysis.…”
Section: Selected Linesmentioning
confidence: 99%
“…Because the mice were not methamphetamine-treated prior to brain biopsy, these differentially expressed genes represent innate genetic differences that might be expected to influence methamphetamine response. Of the genes found to be differentially expressed, some of them reside in the methamphetamine sensitivity QTL regions (Palmer et al, 2005). One that resides on chromosome 15 and was differentially expressed is casein kinase 1 epsilon (Csnk1e).…”
Section: Selected Linesmentioning
confidence: 99%
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“…A subset of these genes could be differentially expressed because there are cis-acting expression QTLs (eQTLs) located on these chromosomes causing the behavioral QTLs. We have previously used such evidence to implicate Csnk1e in methamphetamine response (Palmer et al 2005), and have gone on to show that this same gene is involved in human sensitivity to amphetamine (Veenstra-VanderWeele et al 2006). …”
Section: Microarray and Qtl Studies In The Selected Linesmentioning
confidence: 99%