Abstract:High resolution and noninvasiveness have made soft tissue X-ray microtomography (micro CT) a widely applicable three-dimensional (3D) imaging method in studies of morphology and development. However, scarcity of molecular probes to visualize gene activity with micro CT has remained a challenge. Here we apply horseradish peroxidase -assisted reduction of silver and catalytic gold enhancement of the silver deposit to in situ hybridization in order to detect gene expression in developing tissues with micro CT (he… Show more
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