Gene Expression and Histochemical Analyses in the Fatty Livers of Rats Fed a Histidine-Excess Diet

Fujimi, Takahiko J.; Sate, Mikako; Tsuchiya, Minori; Hirono, Mayuko; Asahi, Riku; Suzuki, Ryuta; Nakajima, Shigeru; Yokoyama, Hiroshi; Matsuura, Tomokazu; Kanzawa, Nobuyuki

doi:10.3177/jnsv.66.561

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Few studies to date underline the contribution of histidine to the NAFLD pathogenesis ( 34 ). Of note, an animal study probed to the contribution of a histidine-excess diet in rats to the high occurrence of minor fibrosis and liver cell damage ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Serum metabolomic profiling unveils distinct sex-related metabolic patterns in NAFLD

Fotakis,

Kalafati,

Amanatidou

et al. 2023

Front. Endocrinol.

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ObjectiveObesity poses an increased risk for the onset of Nonalcoholic fatty liver disease (NAFLD). The influence of other factors, such as sex in the incidence and severity of this liver disease has not yet been fully elucidated. Thus, we aimed to identify the NAFLD serum metabolic signatures associated with sex in normal, overweight and obese patients and to associate the metabolite fluctuations across the increasing liver steatosis stages.Methods and resultsUsing nuclear magnetic resonance (NMR) serum samples of 210 NAFLD cases and control individuals diagnosed with liver U/S, our untargeted metabolomics enquiry provided a sex distinct metabolic bouquet. Increased levels of alanine, histidine and tyrosine are associated with severity of NAFLD in both men and women. Moreover, higher serum concentrations of valine, aspartic acid and mannose were positively associated with the progression of NAFLD among the male subjects, while a negative association was observed with the levels of creatine, phosphorylcholine and acetic acid. On the other hand, glucose was positively associated with the progression of NAFLD among the female subjects, while levels of threonine were negatively related. Fluctuations in ketone bodies acetoacetate and acetone were also observed among the female subjects probing a significant reduction in the circulatory levels of the former in NAFLD cases. A complex glycine response to hepatic steatosis of the female subjects deserves further investigation.ConclusionResults of this study aspire to address the paucity of data on sex differences regarding NAFLD pathogenesis. Targeted circulatory metabolome measurements could be used as diagnostic markers for the distinct stages of NAFLD in each sex and eventually aid in the development of novel sex-related therapeutic options.

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Section: Discussionmentioning

confidence: 99%