Gene expression and functional characterization of serum amyloid P component 2 in rock bream, Oplegnathus fasciatus

Hwang, Seong Don; Bae, Jin-Sol; Jo, D; Kim, Kwang Il; Cho, Mi Young; Jee, Bo Young; Park, Myoung-Ae; Park, Chan-Il

doi:10.1016/j.fsi.2015.09.048

Cited by 13 publications

(6 citation statements)

References 34 publications

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“…Rock bream SAP profiles are also modulated after iridovirus infection with a peak of SAP levels in the liver of infected fish detected at 3 days post-infection [71,72]. Taken together, the aforementioned findings highlight the involvement of APP in a rapid antiviral response in teleost fish.…”

Section: Avian and Fish Virusesmentioning

confidence: 68%

“…Due to their rapid increase after infection, high CRP levels can be used as an early marker of viral disease in fish, before the outcome of the symptoms. However, they could not be used for differential diagnosis, since both viral and bacterial infections induce the upregulation of crp expression in fish [68,72,104,105].…”

Section: App As Biomarkers Of Antiviral Treatment Efficacymentioning

confidence: 99%

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Acute phase protein response to viral infection and vaccination

Pérez

2019

Archives of Biochemistry and Biophysics

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Organisms respond in multiple ways to microbial infections. Pathogen invasion tipically triggers an inflammatory response where acute phase proteins (APP) have a key role. Pentraxins (PTX) are a family of highly conserved APP that play a part in the host defense against infection. The larger proteins of the family are simply named pentraxins, while c-reactive proteins (CRP) and serum amyloid proteins (SAA, SAP) are known as short pentraxins. Although high APP levels have been broadly associated with bacterial infections, there is a growing body of evidence revealing increased PTX, CRP and SAP expression upon viral infection. Furthermore, CRP, PTX and SAP have shown their potential as diagnostic markers and predictors of disease outcome. Likewise, the measurement of APP levels can be valuable to determine the efficacy of antiviral therapies and vaccines. From the practical point of view, the ability of APP to reduce viral infectivity has been observed in several virus-host models. This has prompted investigation efforts to assess the role of acute phase response proteins as immunoregulatory molecules and their potential as therapeutic reagents. This work aims to present an overview of the APP response to viral infections reviewing the current knowledge in the field.

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Section: Avian and Fish Virusesmentioning

confidence: 68%

Section: App As Biomarkers Of Antiviral Treatment Efficacymentioning

confidence: 99%

Acute phase protein response to viral infection and vaccination

Pérez

2019

Archives of Biochemistry and Biophysics

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“…Previously, a high concentration of SAP has been reported to inhibit the growth of Gram-positive and Gram-negative bacteria, as well as to neutralize virus in various aquatic organisms (Hwang et al, 2015;Lee et al, 2017;Shi et al, 2018;Wang & Sun, 2016). Findings demonstrated the ability of SAP to enhance phagocytosis, reduce bacterial burdens and inhibit viral replication in diverse tissue contexts (Li, Bai, et al, 2022).…”

Section: Discussionmentioning

confidence: 97%

Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio‐resistant hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂

Abu Aziz,

Christianus,

Wan Solahudin

et al. 2024

Journal of Fish Diseases

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Vibrio alginolyticus is the causative agent of vibriosis, a common bacterial infection in grouper aquaculture that is associated with the development of haemorrhagic and non‐haemorrhagic ulcerations on the fish. In the present study, comparative proteome analysis was performed on serum samples from Vibrio‐resistant and Vibrio‐susceptible grouper. Samples were analysed using high‐throughput LC‐MS/MS and identified 2770 unique peptides that corresponded to 344 proteins. Subsequent analysis identified 21 proteins that were significantly up‐regulated in the resistant group compared to the control and the susceptible groups. Those proteins are associated with immunostimulatory effects, signalling and binding cascade, metabolism, and maintaining tissue integrity and physiological condition. Besides, potential protein biomarkers related to the immune system were identified, which could be associated with the disease‐resistant phenotype. These data provide insights into the underlying immune mechanism of hybrid groupers upon Vibrio sp. infection.

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“…The ligand-binding properties of fish CRP/SAPs seem species-specific, with some members exhibiting greater similarity to CRP and others to SAP [113] . In fish, the CRP/SAP involvement in the APR is limited to a few teleost species, in which a null or slight effect on CRP/SAP serum levels was observed after stimulation with microbial components or bacterial challenge [75] , [115] , [116] , [117] , [118] , [119] , [120] , [121] , [122] . Sturgeon CRP/SAP pentraxins have been identified and found to be almost identical within the Acipenser genus (> 95 % identity) and conserved across distant ray-finned fish from sturgeons to teleosts (50 % identity) [123] .…”

Section: Acute-phase Proteins (Apps) As Tools For Monitoring Sturgeon...mentioning

confidence: 99%

Innate immune and chronic heat stress responses in sturgeons: Advances and insights from studies on Russian sturgeons

Ferreira,

Aversa-Marnai,

Villarino

et al. 2023

Fish and Shellfish Immunology Reports

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Gene expression and functional characterization of serum amyloid P component 2 in rock bream, Oplegnathus fasciatus

Cited by 13 publications

References 34 publications

Acute phase protein response to viral infection and vaccination

Acute phase protein response to viral infection and vaccination

Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio‐resistant hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂

Innate immune and chronic heat stress responses in sturgeons: Advances and insights from studies on Russian sturgeons

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