Gene Expression Analysis of Bone Tissue Grown on P(VDF-TrFE)/BT Membrane Implanted in Rat Calvarial Defects

Lopes, Helena Bacha; Santos, Thiago de Santana; Freitas, Gileade Pereira; Oliveira, F. de; Gimenes, Rossano; Rosa, Adalberto Luiz; Beloti, Márcio Mateus

doi:10.1016/j.joms.2013.06.162

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“…The ceramic particles, represented by white agglomerations, are evenly distributed in the P(VDF-TrFE) film, represented by the dark area in the SEM image. Additionally, the dispersion of the particles in the matrix is homogeneous, confirming that the copolymer and the ceramic have compatible interfaces, as seen in previous studies [15,29,32,57]. It is worth pointing out that the film stability is adequate when the material is subjected at temperatures above 150 • C, which is when P(VDF-TrFE) melting occurs, and at temperatures above 450 • C where thermal degradation of the copolymer occurs, as described previously in this study.…”

Section: Study Of the Deposition Process: Influence Of The Temperatur...supporting

confidence: 89%

“…The ceramic particles, represented by white agglomerations, are evenly distributed in the P(VDF-TrFE) film, represented by the dark area in the SEM image. Additionally, the dispersion of the particles in the matrix is homogeneous, confirming that the copolymer and the ceramic have compatible interfaces, as seen in previous studies [15,29,32,57]. The use of the spray as a coating technique forces the solvent to migrate to the water droplets deposited in parallel to the composite, causing the precipitation of the P(VDF-TrFE)/BaTiO 3 on the substrate.…”

Section: Study Of the Deposition Process: Influence Of The Temperatur...supporting

confidence: 80%

“…In addition, this ceramic material presents higher piezoelectricity than PVDF [30,31]. In this context, the combination of BaTiO 3 with a copolymer creates a composite P(VDF-TrFE)/BaTiO 3, which has electrical characteristics that promote bone regeneration [27,[32][33][34]. Considering these benefits and possible solutions, the purpose of the present study was to develop a low-cost methodology to coat Ti-30Ta alloys using P(VDF-TrFE)/BaTiO 3 films by employing a spray coating technique at room temperature.…”

Section: Introductionmentioning

confidence: 99%

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Surface Modification of Ti–30Ta Alloy by Deposition of P(VDF-TrFE)/BaTiO3 Coating for Biomedical Applications

Ribeiro

Simões

Espanhol-Soares

et al. 2022

Metals

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This study aims to promote an adequate methodology for coating an experimental Ti-30Ta alloy with P(VDF-TrFE)/BaTiO3. The combination of a copolymer with a ceramic has not been used until now. Ti-30Ta is an excellent choice to replace current alloys in the global market. The composite deposition on the Ti-30Ta substrate was performed by a spray coating process and at low temperature using two different surface modifications: surface acidic etching and surface polishing. Characterization was divided into four areas: (I) the substrate surface treatments used and their influences on the adhesion process were evaluated using surface energy, wettability, and roughness analyses; (II) the properties of the composite film, which were carried out using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG), and differential scanning calorimetry (DSC); (III) the study of the adhesion of the film on the substrate, which was performed by a scratch test; (IV) the final product, which was evaluated to determine the surface properties after the coating process. Biofilm formation using Staphylococcus aureus and Staphylococcus epidermidis strains and a hemocompatibility test were performed as biological assays. The results indicated that the P(VDF-TrFE)/BaTiO3 film showed high thermal stability (up to ≈450 °C); the FTIR and DSC tests indicated the presence of the β phase, which means that the material presents a piezoelectric nature; and the scratch test showed that the samples with the polish treatment provided a better adhesion of the film with an adhesion strength of ~10 MPa. From the SEM analysis, it was possible to determine that the spray deposition coating process resulted in a well-applied film as evidenced by its homogeneity. Microbiological tests showed that for Staphylococcus aureus, the bacterial growth in the coated Ti-30Ta presented no significant differences when compared to the alloy without coating. However, for Staphylococcus epidermidis, there was considerable growth on the coated Ti-30Ta, when compared to the non-coated alloy, indicating that the film surface may have favored bacterial growth. The hemolysis assay showed that the coated material presents hemocompatible characteristics when in contact with blood cells. The results obtained indicate that the Ti-30Ta alloy coated with P(VDF-TrFE)/BaTiO3 is a promising alternative for implant applications, due to its biocompatible properties, simplicity, and low cost.

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Section: Study Of the Deposition Process: Influence Of The Temperatur...supporting

confidence: 89%

“…The ceramic particles, represented by white agglomerations, are evenly distributed in the P(VDF-TrFE) film, represented by the dark area in the SEM image. Additionally, the dispersion of the particles in the matrix is homogeneous, confirming that the copolymer and the ceramic have compatible interfaces, as seen in previous studies [15,29,32,57]. The use of the spray as a coating technique forces the solvent to migrate to the water droplets deposited in parallel to the composite, causing the precipitation of the P(VDF-TrFE)/BaTiO 3 on the substrate.…”

Section: Study Of the Deposition Process: Influence Of The Temperatur...supporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surface Modification of Ti–30Ta Alloy by Deposition of P(VDF-TrFE)/BaTiO3 Coating for Biomedical Applications

Ribeiro

Simões

Espanhol-Soares

et al. 2022

Metals

View full text Add to dashboard Cite

show abstract

Gene Expression Analysis of Bone Tissue Grown on P(VDF-TrFE)/BT Membrane Implanted in Rat Calvarial Defects

Cited by 1 publication

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Surface Modification of Ti–30Ta Alloy by Deposition of P(VDF-TrFE)/BaTiO3 Coating for Biomedical Applications

Surface Modification of Ti–30Ta Alloy by Deposition of P(VDF-TrFE)/BaTiO3 Coating for Biomedical Applications

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