Gene expression analysis of arbuscule development and functioning

Franken, Philipp; Donges, Katrin; Grunwald, Ulf; Kost, Gerhard; Rexer, Karl‐Heinz; Tamasloukht, M'Barek; Waschke, Astrid; Zeuske, Dorit

doi:10.1016/j.phytochem.2006.09.027

Cited by 23 publications

(10 citation statements)

References 60 publications

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“… DDD (A17‐Differentially expressed, DMI 3‐Dependent, NSP 1‐Dependent), DDI A17‐Differentially expressed, DMI 3‐Dependent, NSP 1‐Independent), GENOTYPE , GENOTYPE ( DMI 3+ NSP 1) and TREATMENT genes found in 34 publications exploring symbiotic transcriptomic reprogramming in Medicago truncatula . (a) Numbers and proportions of genes identified in the transcriptomic literature of the arbuscular mycorrhizal symbiosis ( AMS ) (Liu et al ., , ; Wulf et al ., ; Brechenmacher et al ., ; Weidmann et al ., ; Frenzel et al ., ; Hohnjec et al ., ; Franken et al ., ; Massoumou et al ., ; Siciliano et al ., ; Gomez et al ., ; Grunwald et al ., ; Benedito et al ., ; Kuhn et al ., ; Devers et al ., ; Hogekamp et al ., ; Gaude et al ., ; Tromas et al ., ), and/or of the rhizobium–legume symbiosis ( RLS ) (Favery et al ., ; Journet et al ., ; El Yahyaoui et al ., ; Manthey et al ., ; Mitra et al ., ; Hohnjec et al ., ; Lohar et al ., ; Starker et al ., ; Godiard et al ., ; Kuster et al ., ; van Noorden et al ., ; Benedito et al ., , ; Ferrarini et al ., ; Jones et al ., ; Moreau et al ., ; Tromas et al ., ). For each of the five groups, the number of genes found in any of these studies and the total number of genes in the group are indicated.…”

Section: Resultsmentioning

confidence: 99%

Combined genetic and transcriptomic analysis reveals three major signalling pathways activated by Myc‐LCOs in Medicago truncatula

et al. 2015

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SummaryMyc-LCOs are newly identified symbiotic signals produced by arbuscular mycorrhizal (AM) fungi. Like rhizobial Nod factors, they are lipo-chitooligosaccharides that activate the common symbiotic signalling pathway (CSSP) in plants. To increase our limited understanding of the roles of Myc-LCOs we aimed to analyse Myc-LCO-induced transcriptional changes and their genetic control.Whole genome RNA sequencing (RNA-seq) was performed on roots of Medicago truncatula wild-type plants, and dmi3 and nsp1 symbiotic mutants affected in nodulation and mycorrhizal signalling. Plants were treated separately with the two major types of Myc-LCOs, sulphated and nonsulphated.Generalized linear model analysis identified 2201 differentially expressed genes and classified them according to genotype and/or treatment effects. Three genetic pathways for Myc-LCO-regulation of transcriptomic reprogramming were highlighted: DMI3-and NSP1-dependent; DMI3-dependent and NSP1-independent; and DMI3-and NSP1-independent. Comprehensive analysis revealed overlaps with previous AM studies, and highlighted certain functions, especially signalling components and transcription factors.These data provide new insights into mycorrhizal signalling mechanisms, supporting a role for NSP1, and specialisation for NSP1-dependent and -independent pathways downstream of DMI3. Our data also indicate significant Myc-LCO-activated signalling upstream of DMI3 and/or parallel to the CSSP and some constitutive activity of the CSSP.

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Section: Resultsmentioning

confidence: 99%

Combined genetic and transcriptomic analysis reveals three major signalling pathways activated by Myc‐LCOs in Medicago truncatula

et al. 2015

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“…The establishment of this successful biotrophic association result from a complex, dynamic and still largely unknown signalling mechanism involving major changes in fungal and plant gene expression (Franken et al 2007;Fiorilli et al 2009). Many studies have described the colonization process, from the early signalling in noncontacting organisms to root surface contact and development of a pre-penetration apparatus (Genre et al 2005), followed by fungal penetration and proliferation within and between cells.…”

Section: Introductionmentioning

confidence: 99%

Transcriptional regulation of defence genes and involvement of the WRKY transcription factor in arbuscular mycorrhizal potato root colonization

Gallou

Declerck

Cranenbrouck

2011

Funct Integr Genomics

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The establishment of arbuscular mycorrhizal associations causes major changes in plant roots and affects significantly the host in term of plant nutrition and resistance against biotic and abiotic stresses. As a consequence, major changes in root transcriptome, especially in plant genes related to biotic stresses, are expected. Potato microarray analysis, followed by real-time quantitative PCR, was performed to detect the wide transcriptome changes induced during the pre-, early and late stages of potato root colonization by Glomus sp. MUCL 41833. The microarray analysis revealed 526 up-regulated and 132 down-regulated genes during the pre-stage, 272 up-regulated and 109 down-regulated genes during the early stage and 734 up-regulated and 122 down-regulated genes during the late stage of root colonization. The most important class of regulated genes was associated to plant stress and in particular to the WRKY transcription factors genes during the pre-stage of root colonization. The expression profiling clearly demonstrated a wide transcriptional change during the pre-, early and late stages of root colonization. It further suggested that the WRKY transcription factor genes are involved in the mechanisms controlling the arbuscular mycorrhizal establishment by the regulation of plant defence genes.

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“…There is a paucity of data even at the in vitro level, since not many studies have focused on how berry polyphenols may affect AE-activity. This research is even more imperative since, in the internet era, much information is available to the public regarding the possible “beneficial” effects of these compounds that may or may not be substantiated by original research (118). The onus is on the scientific community to provide persuasive evidence for the protective effect of berries and berry polyphenols in prevention of recurrent breast cancer, especially when provided alongside routine endocrine therapies.…”

Section: Perspective-berries In the Prevention Of Breast Cancermentioning

confidence: 99%

Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention

Aiyer

Wärri

Woode

et al. 2012

J. Agric. Food Chem.

110

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Breast cancer is the most commonly diagnosed cancer among women worldwide. Many women have become more aware of the benefits of increasing fruit consumption, as part of a healthy lifestyle, for the prevention of cancer. The mechanisms by which fruits, including berries, prevent breast cancer can be partially explained by exploring their interactions with pathways known influence cell-proliferation and evasion of cell-death. Two receptor pathways- estrogen receptor (ER) and tyrosine kinase receptors, especially the epidermal growth factor receptor (EGFR) family- are drivers of cell-proliferation and play a significant role in the development of both primary and recurrent breast cancer. There is strong evidence to show that several phytochemicals present in berries such as cyanidin, delphinidin, quercetin, kaempferol, ellagic acid, resveratrol and pterostilbene, interact with and alter the effects of these pathways. Further, they also induce cell death (apoptosis and autophagy) via their influence on kinase signaling. In this review, we summarize in vitro data regarding the interaction of berry polyphenols with the specific receptors and the mechanisms by which they induce cell death. Further, we also present in vivo data of primary breast cancer prevention by individual compounds and whole berries. Finally, we present a possible role for berries and berry compounds in the prevention of breast cancer and our perspective on the areas that require further research.

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Gene expression analysis of arbuscule development and functioning

Cited by 23 publications

References 60 publications

Combined genetic and transcriptomic analysis reveals three major signalling pathways activated by Myc‐LCOs in Medicago truncatula

Combined genetic and transcriptomic analysis reveals three major signalling pathways activated by Myc‐LCOs in Medicago truncatula

Transcriptional regulation of defence genes and involvement of the WRKY transcription factor in arbuscular mycorrhizal potato root colonization

Influence of Berry Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention

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