Gene expression analysis in scars treated with silicone cream: a case series

Kikuchi, Robin; Khalil, Abdullah J; Zoumalan, Christopher I.

doi:10.1177/2059513119868345

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Mustoe [61] suggested that occlusion and hydration downregulate keratinocyte stimulation and in turn cause a decrease of fibroblast activity. Other studies demonstrated that SGS decreases TGF-β1 and TGF-β2 expression in fibroblasts [62,63], and Kikuchi and co-workers [64] demonstrated that scars treated with silicone gel show favorable gene expression for wound healing. The application of SG promoted the maturation of burn scars in most cases and significantly improved the surface roughness of the scars [65].…”

Section: Silicone Therapymentioning

confidence: 98%

Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring

Daele

Meirte

Anthonissen

et al. 2022

EBJ

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Every year, surgical interventions, traumatic wounds, and burn injuries lead to over 80 million scars. These scars often lead to compromised skin function and can result in devastating disfigurement, permanent functional loss, psychosocial problems, and growth retardation. Today, a wide variety of nonsurgical scar management options exist, with only few of them being substantiated by evidence. The working mechanisms of physical anti-scarring modalities remained unclear for many years. Recent evidence underpinned the important role of mechanical forces in scar remodeling, especially the balance between matrix stiffness and cytoskeleton pre-stress. This perspective article aims to translate research findings at the cellular and molecular levels into working mechanisms of physical anti-scarring interventions. Mechanomodulation of scars applied with the right amplitude, frequency, and duration induces ECM remodeling and restores the ‘tensile’ homeostasis. Depending on the scar characteristics, specific (combinations of) non-invasive physical scar treatments are possible. Future studies should be aimed at investigating the dose-dependent effects of physical scar management to define proper guidelines for these interventions.

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Section: Silicone Therapymentioning

confidence: 98%

Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring

Daele

Meirte

Anthonissen

et al. 2022

EBJ

View full text Add to dashboard Cite

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Comparison of Conservative Methods of Prevention of Pathological Scaring of the Head and Neck

Nahirniy

2022

Med. and Ecol. probl.

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Wound healing is one of the most common and complex processes, which includes five phases: hemostasis, inflammation, proliferation, re-epithelialization, and remodeling. Each stage of wound healing requires the complex synchronization and regulation of multiple cell populations. Violation of the link of any of these processes can lead to the appearance of complications and increase the likelihood of the formation of pathological scars. To study the research materials, we used the bibliosemantic and analytical method, with the help of which we processed the literary data, as well as the materials of clinical studies, which were posted on the Internet. There are many conservative methods of prevention of the pathological scars formation in the area of head and neck, one of the main links is occupied by ointments with different components. Thus, a clinical study by Marquardt Y showed that the local application of dexpanthenol in the form of an ointment contributes to better healing of superficial and postoperative wounds. According to foreign scientists, silicone products, both in the form of sheets and gel, are considered to be the first line in the prevention and treatment of hypertrophic and keloid scars. Goutos I., suggested the use of corticosteroid tape, which is a painless alternative to corticosteroid injections. Japanese scientists Ogawa R and co-authors note the good clinical experience and results of using corticosteroid tape and patch. Recent research by Powell HM., 2022 on the use of pressure therapy for lacerations has shown that tension relief is a powerful strategy to prevent scar formation in the head and neck area. Ud-Din S et al., proposed photodynamic therapy, which has a good evidence base for the effectiveness of this method. Over the past decade, many high-quality studies have been conducted, increasing the level of evidence base for many prevention or treatment regimens. The article reflects modern methods of conservative prevention, however, taking into account ethnic differences, predisposition to pathological scars, algorithms for prevention and treatment should be refined and optimized.

show abstract

Gene expression analysis in scars treated with silicone cream: a case series

Cited by 2 publications

References 14 publications

Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring

Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring

Comparison of Conservative Methods of Prevention of Pathological Scaring of the Head and Neck

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