Gene expression analysis in induced sputum from welders with and without airway-related symptoms

Jönsson, Lena; Nielsen, Jörn; Broberg, Karin

doi:10.1007/s00420-010-0579-2

Cited by 13 publications

(9 citation statements)

References 30 publications

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“…It is reason to believe that we are witnesses to the effects of processes in the mucous membranes elicited by the injury from the welding environment and modified by repair processes as described in experimental studies of Oh et al (2009), Leonard et al (2010), from our group in some of the symptomatic welders studied separately (Jönsson et al 2011) and furthermore in a cross-sectional study of mild steel welders by Hoffmeyer et al (2012). However, there is still a lack of knowledge concerning the dose–response relationships and of the mechanisms.…”

Section: Discussionmentioning

confidence: 82%

The ordinary work environment increases symptoms from eyes and airways in mild steel welders

Jönsson

Tinnerberg

Jacobsson

et al. 2015

Int Arch Occup Environ Health

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Purpose We aimed to follow diary-registered symptoms from eyes and airways in mild steel welders and relate them to different exposure measures. Furthermore, we would clarify the influence of possible effect modifiers.Methods Non-smoking welders with (N = 74) and without (N = 32) work-related symptoms the last month were enroled. Symptoms and work tasks each day for three two-week periods during 1 year were obtained. Respirable dust (RD) was measured 1 day each period for each worker. The personal daily exposure was assessed as: (1) days at work, (2) welding time and (3) estimates of RD from welding and grinding, calculated from diary entries and measurements.ResultsOnly 9.2 % of the particle measurements exceed the Swedish occupational exposure limit (OEL; 5 mg/m3). Days at work increased the risk of symptoms studied: eyes: 1.79 (1.46–2.19), nasal: 2.16 (1.81–2.58), dry cough: 1.50 (1.23–1.82) and wheezing and/or dyspnoea: 1.27 (1.03–1.56; odds ratio, 95 % confidence interval). No clear dose–response relationships were found for the other exposure estimates. Eye symptoms increased by number of years welding. Nasal symptoms and dry cough increased having forced expiratory volume in first second below median at baseline. Wheezing and/or dyspnoea increased in winter, by number of years welding, having a negative standard skin-prick test and having a vital capacity above median at baseline.ConclusionThe current Swedish OEL may not protect welders against eye and airway symptoms. The results add to the evidence that welders should be offered regular medical surveillance from early in the career.

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Section: Discussionmentioning

confidence: 82%

The ordinary work environment increases symptoms from eyes and airways in mild steel welders

Jönsson

Tinnerberg

Jacobsson

et al. 2015

Int Arch Occup Environ Health

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“…Jönsson et al [23] showed a response to welding fumes by changes in gene expression associated with inflammation and defense. Furthermore, they indicates changes in CSF3R, MMP25 and TNFAIP6 during exposure to welding fumes among asthmatic compared to nonsymptomatic welders, but this needs to be confirmed.…”

Section: Discussion and Prospectmentioning

confidence: 99%

“…Thus, the microarray and qPCR technique were able to reveal markers of exposure to welding fumes and possible disease-related markers. However, further studies are needed to verify the genes involved and to further characterize the mechanism for welding-fume-associated lower airway symptoms [23].…”

Section: Toxicogenomics Of Humans Exposed To Welding Fumesmentioning

confidence: 99%

Toxicogenomic Approach to Risk Assessment of Welding Fumes

Rim¹

2012

J Clin Toxicol

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The welding fume exposure of welders mainly occurs though the inhalation of a mixture of metals, chemicals, and dust in the workplace. Several studies have already attempted to identify the pathophysiological process of welding-fume-exposure-induced lung diseases, as well as manganism. Moreover, microarray technology offers the ability to investigate the entire genome after exposure to welding fumes, and permits characterization of the biological effects due to welding fume exposure. This review summarizes the published literature on the genetic and transcriptional profiles resulting from the exposure of cells or organisms to welding fumes as complex environmental mixtures in the workplace. Researchers are also actively studying how toxicogenomics can be effectively used for risk assessment of welding fumes, as discussed throughout this review. Jour n a l o f C linical T o x ic o log y

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“…Biomarkers of effect and of expo sure to welding fumes were discovered using the micro array and realtimePCR. Nevertheless, verification of the potential genes and characterization of the mecha nism underlying weldingfume associated lower airway symptoms are further warranted 20 .…”

Section: Integrative Toxicogenomic Analysismentioning

confidence: 99%

Integrative toxicogenomics-based approach to risk assessment of heavy metal mixtures/complexes: strategies and challenges

Koedrith

Kim

Seo

2015

Mol. Cell. Toxicol.

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Human exposure to metallic elements rang ing from single metal ionic salt, metal compounds, and metal mixtures that may occur naturally, as well as from human activities and industrial applications. Some metals including arsenic, cadmium, chromium, lead, mercury, and nickel in both single element and mixture forms render confounding health effects and ultimately cause cancer. Studies of heavy metalme diated global aberration using nontargeted multiple toxicogenomic technologies might help to elucidate environmentally relevant disorders, as well as to mon itor biomarker of exposure and predict the health risk toward environmental toxicants. We describe recent toxicogenomic studies on heavy metal mixtures as well as relevant mechanism of toxicity and molecu lar signatures. On the basis of system toxicology ap proach, integrative toxicogenomic and bioinformatic tools might represent the biological pathways linked to disorders. We also strongly suggest that the toxicog enomic data can be adopted to risk assessment pro cess. Furthermore, we mention challenges in utility of toxicogenomic studies data to risk assessment process of toxicity of metal mixtures. Overall, we realize that application and interpretation of toxicogenomic data regarding to their strengths and weaknesses would po tentiate chemical risk assessment.

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Gene expression analysis in induced sputum from welders with and without airway-related symptoms

Cited by 13 publications

References 30 publications

The ordinary work environment increases symptoms from eyes and airways in mild steel welders

The ordinary work environment increases symptoms from eyes and airways in mild steel welders

Toxicogenomic Approach to Risk Assessment of Welding Fumes

Integrative toxicogenomics-based approach to risk assessment of heavy metal mixtures/complexes: strategies and challenges

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