Gene expression analysis in burn wounds of rats

Abstract

The events occurring early in the burn wound trigger a sequence of local and systemic responses that influence cell and tissue survival and, consequently, wound healing and recovery. Using high-density oligonucleotide arrays we identified gene expression patterns in skin samples taken from a region of injury in the burn rat model. The associated genomic events include the differential expression of genes involved in cell survival and death, cell growth regulation, cell metabolism, inflammation, and immune response. The functional gene cluster detected and their time appearance matched the time sequence known to occur in burn wound healing.

Transcriptome network analysis of potential candidate genes for heart failure

“…DNA microarray analysis is a global approach to investigating physiological mechanisms in health and disease (Spies et al, 2002). A high-throughput microarray experiment has been designed to analyze genetic expression patterns and identify potential genes to target HF (Xu et al, 2011).…”

Transcriptome Network Analysis Reveals Potential Candidate Genes for Esophageal Squamous Cell Carcinoma

“…DNA microarray analysis as a global approach is applied to investigate physiological mechanisms in health and disease (Spies et al, 2002). The microarray experiment significant reduction of MDR1 expression was observed in patients suggesting that MDR1 might affect the sensitivity of 5FU and/or CDDP in the adjuvant chemotherapy for esophageal cancers (Kihara et al, 2001).…”

Obtain osteoarthritis related molecular signature genes through regulation network

“…DNA microarray analysis as a global approach is applied to investigate physiological mechanisms in health and disease (3). The development of reliable gene expression profiling technology has an increasing impact on our understanding of OA (4).…”