Gene–Environment Interplay and Individual Differences in Behavior

Anreiter, Ina; Sokolowski, H. Moriah; Sokolowski, Marla B.

doi:10.1111/mbe.12158

Cited by 30 publications

(31 citation statements)

References 117 publications

(155 reference statements)

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“…Much has been written about relations between genes and environments and their effects on health, well-being, and behavior (for reviews, see refs. [12][13][14]. Historically, these writings were rooted in arguments over whether nature (genes) or nurture (environments) were responsible for individual differences in behavioral traits.…”

Section: Gene-environment Interplaymentioning

confidence: 99%

“…After the debunking of this nature-nurture dichotomy, discussions turned to the idea that both genes and the environment contribute additively to individual differences in risk and behavior and that the size of the contributions depended upon the outcome of interest. Statistical analyses of large populations later revealed the importance of G-E interactions and G-E correlation in human behavior genetic research (14)(15)(16). G-E interactions occur when genetically different individuals exhibit different responses to environmental variation.…”

Section: Gene-environment Interplaymentioning

confidence: 99%

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Genes and environments, development and time

Boyce

Sokolowski

Robinson

2020

Proc. Natl. Acad. Sci. U.S.A.

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A now substantial body of science implicates a dynamic interplay between genetic and environmental variation in the development of individual differences in behavior and health. Such outcomes are affected by molecular, often epigenetic, processes involving gene–environment (G–E) interplay that can influence gene expression. Early environments with exposures to poverty, chronic adversities, and acutely stressful events have been linked to maladaptive development and compromised health and behavior. Genetic differences can impart either enhanced or blunted susceptibility to the effects of such pathogenic environments. However, largely missing from present discourse regarding G–E interplay is the role of time, a “third factor” guiding the emergence of complex developmental endpoints across different scales of time. Trajectories of development increasingly appear best accounted for by a complex, dynamic interchange among the highly linked elements of genes, contexts, and time at multiple scales, including neurobiological (minutes to milliseconds), genomic (hours to minutes), developmental (years and months), and evolutionary (centuries and millennia) time. This special issue of PNAS thus explores time and timing among G–E transactions: The importance of timing and timescales in plasticity and critical periods of brain development; epigenetics and the molecular underpinnings of biologically embedded experience; the encoding of experience across time and biological levels of organization; and gene-regulatory networks in behavior and development and their linkages to neuronal networks. Taken together, the collection of papers offers perspectives on how G–E interplay operates contingently within and against a backdrop of time and timescales.

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Section: Gene-environment Interplaymentioning

confidence: 99%

Section: Gene-environment Interplaymentioning

confidence: 99%

Genes and environments, development and time

Boyce

Sokolowski

Robinson

2020

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

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“…Depression-like behavioral phenotypes vary widely between strains and species, and therefore cross-strain/species translations of data should be performed carefully 197 . Furthermore, individual differences in animal models also exist, and must be considered 198 . In fact, rodents exhibit a wide population variety in depression-like behaviors, and can be selectively bred for depression-like traits (e.g., Flinders Sensitive Line, Swim Low-Active and Helpless Rouen strains) 26, 199-213 .…”

Section: Resultsmentioning

confidence: 99%

Animal models of major depressive disorder and the implications for drug discovery and development

Demin

Sysoev

Chernysh

et al. 2019

Expert Opinion on Drug Discovery

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Depression is a highly debilitating syndrome that affects the global population and is associated with disabilities and suicide. Depression remains poorly studied and is often treatment resistant and recurrent. Thus, development of new therapies and drugs is needed in the field. Animal models are indispensable for translational biological psychiatry, and may advance the study of depression. While poor understating of psychiatric disorders (including depression) is slowing down further progress in the field, novel approaches continuously emerge that may help untangle disorder heterogeneity and blurred categories of contemporary diseases classification systems. Dividing core symptoms into easily translatable phenotypes is an effective way to reevaluate current paradigms. Also, other, more deep and complicated approaches and theories based on the endophenotype paradigm, such as 'cross-species trait genetic' and 'domain interplay concept' do continuously emerge to improve current paradigms and drug screening.

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“…8 Children also have unique biological compositions that influence the way they interact with the world, while the environment influences their biology. 88 Biological consequences of abuse and neglect are dependent on developmental timing 42 and genetic predispositions. 9,30,34,35 From an ecological perspective, human development occurs through this complex process of a biopsychological human interacting with the environment.…”

Section: Discussionmentioning

confidence: 99%

Intergenerational Transmission of Child Abuse and Neglect: A Transdisciplinary Analysis

Wert

Anreiter

Fallon

et al. 2019

Gender and the Genome

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Parents who experienced maltreatment in childhood may be at an increased risk of presenting abusive or neglectful behavior toward their own children. Research suggests reoccurring patterns of abuse and neglect across generations, but the factors that influence these behavioral patterns are complex and poorly understood. Although abusive or neglectful parenting styles undoubtedly are strongly influenced by social factors (ie, "nurture"), there might be underlying biological components to perpetuating behavioral patterns (ie, "nature"). Importantly, nature and nurture are known to interact in shaping developmental outcomes, and as such should not be considered in isolation. In this review, we examine the evidence regarding the inheritance of abusive and/or neglectful parenting behavior using a transdisciplinary approach. We integrate knowledge of the social and biological science fields on the continuance of abusive and neglectful behavior, as well as the methodological challenges that complicate the interpretation of existing research. Finally, we stress the importance of considering contextual factors of both social and biological research findings concerning the intergenerational inheritance of child abuse and neglect and discuss the potential for early social intervention to disrupt harmful intergenerational patterns.

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Gene–Environment Interplay and Individual Differences in Behavior

Cited by 30 publications

References 117 publications

Genes and environments, development and time

Genes and environments, development and time

Animal models of major depressive disorder and the implications for drug discovery and development

Intergenerational Transmission of Child Abuse and Neglect: A Transdisciplinary Analysis

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