Gene-environment interaction: The causes of high obesity incidence

Abstract

Urbanization has provided experimental settings for testing the interactive relationship between genetic background and changes in lifestyle and dietary patterns. The concept of gene-environment interaction was described by epidemic of obesity along with urbanization. Genome-wide association has identified several genes such as melanocortin-4 receptor that associates with environmental influences of obesity. Gene environment (GxE) interaction refers to modification by an environmental factor of the effect of a genetic variant on a phenotypic trait. GxE interactions can serve to modulate the adverse effects of a risk allele, or can exacerbate the genotypephenotype relationship and increase risk.

Extra‐Virgin Olive Oil with Natural Phenolic Content Exerts an Anti‐Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr−/−.Leiden Mice

“…Obesity-associated inflammation is closely linked to the development and progression of atherosclerosis and other serious health problems such as metabolic syndrome, diabetes mellitus, and cancer. [1] The biological processes that link adipose tissue inflammation to the development of atherosclerosis are not fully understood, namely in the context of diet-induced obesity.…”

Dietary and Lifestyles assessment among Obese Women in Gaza City, Palestine

“…Furthermore, the absence of childhood obesity and family history have reduced the risk of adulthood obesity and co-morbidity and reduced the risk of chronic diseases in the future. Genetics alone cannot explain obesity, gene-environment interaction can explain the high incidence of obesity [39]. Reports suggest that environmental factors are largely associated with the development of an obesity status and it also concludes that genetics only contributes 30% to the issue and 70% is attributed to the environment [40].…”

Mối liên quan giữa đa hình nucleotide đơn rs6548238 gen TMEM18 và béo phì ở trẻ tiểu học Hà Nội

“…Ở nước ta hiện nay tỷ lệ trẻ béo phì đang tăng lên nhanh chóng đặc biệt là khu vực thành thị [2][3]. Béo phì là một bệnh đa nhân tố, do ảnh hưởng của các yếu tố môi trường [4] và yếu tố di truyền (gen) [5], cũng như sự tương tác giữa gen và môi trường [6]. _______ * Tác giả liên hệ.…”