Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding

Klingenberg, Boris; Gülöksüz, Sinan; Pries, Lotta-Katrin; Cinar, Ozan; Menne-Lothmann, Claudia; Decoster, Jeroen; Winkel, Ruud van; Collip, Dina; Delespaul, Philippe; Hert, Marc De; Derom, Cathérine; Thiery, Evert; Jacobs, Nele; Wichers, Marieke; Lin, Bochao; Luykx, Jurjen J.; Os, Jim van; Rutten, Bart P. F.

doi:10.1017/pen.2023.2

Cited by 3 publications

(1 citation statement)

References 68 publications

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“…These remain open possibilities that should be tested in future research. Finally, other recent attempts at investigating gene-environment interplay using PGSs have similarly not found effects (Armitage et al, 2022;Klingenberg et al, 2023). This may be indicative of the limitations of PGSs for investigating the effects of gene-environment interplay given they only represent a proportion of genetic variation.…”

Section: Sibling Bullying and Genetics Are Associated With Mental Hea...mentioning

confidence: 92%

Genetic Influences on Sibling Bullying and Mental Health Difficulties

Toseeb¹,

vincent²,

Asbury³

2023

Preprint

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Background. Sibling bullying is associated with mental health difficulties; both in the short and long term. It is commonly assumed that sibling bullying leads to mental health difficulties but observational studies rarely allow for such inferences to be made. Method. To ad-dress this gap in knowledge, we used a genetically sensitive design with data from the Avon Longitudinal Study of Parents and Children (maximum N=3,959). At ages 12-13 years, individuals self-reported their involvement in sibling bullying, as a victim and perpetrator, and parents reported on their child’s mental health difficulties. Polygenic scores, in-dices of genetic risk for psychiatric disorders (major depressive disorder and attention deficit hyperactivity disorder) were computed using children’s genetic data. Regression and structural equation models were fitted to the data. Results. Sibling bullying and polygenic scores both independently predicted mental health difficulties but the relationship between sibling bullying and mental health difficulties was not moderated by genetic risk. Addition-ally, polygenic scores for mental health difficulties were associated with both sibling bully-ing and mental health difficulties. Conclusion. These findings suggest that the relationship between sibling bullying and mental health difficulties is not simply causal; sibling bullying and mental health difficulties may be, at least partly, related due to shared genetic etiology.

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Section: Sibling Bullying and Genetics Are Associated With Mental Hea...mentioning

confidence: 92%

Genetic Influences on Sibling Bullying and Mental Health Difficulties

Toseeb¹,

vincent²,

Asbury³

2023

Preprint

View full text Add to dashboard Cite

show abstract

Genetic influences on sibling bullying and mental health difficulties

Toseeb,

Vincent,

Asbury

2024

Child Psychology Psychiatry

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BackgroundSibling bullying is associated with mental health difficulties; both in the short and long term. It is commonly assumed that sibling bullying leads to mental health difficulties but additional explanations for the relationship between the two are seldom investigated.MethodsTo address this gap in knowledge, we used a genetically sensitive design with data from the Avon Longitudinal Study of Parents and Children (maximum N = 3,959, 53% female). At ages 11–13 years, individuals self‐reported their involvement in sibling bullying, as a victim and perpetrator, and parents reported on their child's mental health difficulties. Polygenic scores, indices of genetic risk for psychiatric disorders (major depressive disorder and attention deficit hyperactivity disorder) were computed using children's genetic data. Regression and structural equation models were fitted to the data.ResultsSibling bullying, victimisation and perpetration, and polygenic scores both predicted mental health difficulties in an additive manner but there was no interaction between them. Polygenic scores for mental health difficulties were also associated with sibling bullying.ConclusionsThese findings suggest that sibling bullying, victimisation and perpetration, is associated with mental health difficulties, even after accounting for some genetic effects. Additionally, the relationship between sibling bullying and mental health difficulties may be, at least partly, due to shared genetic aetiology. One possibility is that genetic risk for mental health difficulties influences the onset of mental health difficulties which in turn make children more susceptible to sibling bullying.

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Influence of Neuroticism and Locus of Control on Anxiety Among Students in Higher Education Institutions

Gangadharan,

Sathiyaseelan,

Dharam

et al. 2024

Advances in Higher Education and Professional Development

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Anxiety is a negative state of mind resulting from conflicts and frustration experienced within ourselves. Anxiety often leads to undesired consequences like stress, confusion, fear, insecurity, distress, and panic. The most common causes of anxiety are perceived lack of control over one's life and fear of being wrong. Anxiety related to academics and career are major concern experienced by students especially in higher education institutions. Since they are exposed to many novel situations, there is a higher risk among them interpreting these situations as threatening. The present study aims to understand how neuroticism and locus of control together predict anxiety among students. A cross-sectional design is used in the study and data on anxiety, locus of control and neuroticism among adolescents and young adults were collected. It was found that neuroticism and LoC significantly predicts anxiety suggesting the need for early interventions and a positive and inclusive environment to modify the dysfunctional thought processes associated with neuroticism and external locus of control.

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Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding

Cited by 3 publications

References 68 publications

Genetic Influences on Sibling Bullying and Mental Health Difficulties

Genetic Influences on Sibling Bullying and Mental Health Difficulties

Genetic influences on sibling bullying and mental health difficulties

Influence of Neuroticism and Locus of Control on Anxiety Among Students in Higher Education Institutions

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