Gene/environment interaction in the susceptibility of Crohn's disease patients to aluminum

Djouina, Madjid; Waxin, Christophe; Leprêtre, Frédéric; Tardivel, Meryem; Tillement, Olivier; Vasseur, Francis; Figeac, Martin; Bongiovanni, Antonino; Desreumaux, Pierre; Launay, David; Dubuquoy, Laurent; Body-Malapel, Mathilde; Vignal, Cécile

doi:10.1016/j.scitotenv.2022.158017

Cited by 7 publications

(3 citation statements)

References 46 publications

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“…NHE3 is highly expressed in the apical membrane of the proximal tubules of the small intestine and colon, colon, and kidney, and is mainly responsible for neutral electrical uptake of Na + . NHE3 usually interacts with Cl − /HCO 3− , NaCl exchanger downregulated in adenomas (Dra; SLC26A3) [ 23 ] or possibly anion transporter 1 (PAT1; SLC26A6) [ 24 ] were conjugated to function. Previous studies have shown that NHE3 −/− mice have defects in intestinal and renal ion absorption, resulting in acid-base imbalance and deranged sodium levels [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Jian-Pi-Yin decoction attenuates lactose-induced chronic diarrhea in rats by regulating GLP-1 and reducing NHE3 ubiquitination and phosphorylation

Ma,

Chen,

Xue

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Jian-Pi-Yin decoction attenuates lactose-induced chronic diarrhea in rats by regulating GLP-1 and reducing NHE3 ubiquitination and phosphorylation

Ma,

Chen,

Xue

et al. 2023

Heliyon

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“…Moreover, when bacterial antigens induce abnormal activation of adaptive immune cells, the irrepressible immune response forces further aggravation of CD damage [ 19 ]. Admittedly, although genetic and environmental differences in CD patients remain elusive, strong evidence for a dysregulated immune response may be attributed to a T cell-mediated inflammatory cascade [ 20 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Single-Cell Sequencing-Based Validation of T Cell-Associated Diagnostic Model Genes and Drug Response in Crohn’s Disease

Dai

Zhang

et al. 2023

IJMS

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Crohn’s disease is a highly heterogeneous autoimmune disease with a unique inflammatory phenotype of T cells at the lesion site. We aim to further explore the diagnosis of Crohn’s disease and drug prediction of T cell marker gene expression. We obtained single-cell expression profile data from 22 CDs or normal samples and performed cell annotation and cellular communication analysis. Through the intersection of T cell marker genes, differential genes, and WGCNA results, we identified T cell-specific key genes and their immune landscapes and potential pathogenesis, and validated them across multiple datasets and patient tissue samples. We also explored the differentiation characteristics of genes by pseudo-temporal analysis and assessed their diagnostic performance and drug sensitivity by molecular docking. Finally, we extended this study to the prognosis of IBD-associated colon cancer. TNF-centered 5-gene diagnostic model not only has excellent diagnostic efficacy, but is also closely associated with KRAS, P53, and IL6/JAK/STAT3 pathways and physiological processes, such as EMT, coagulation, and apoptosis. In addition, this diagnostic model may have potential synergistic immunotherapeutic effects, with positive correlations with immune checkpoints such as CTLA4, CD86, PDCD1LG2, and CD40. Molecular docking demonstrated that BIRC3 and ANXA1 have strong binding properties to Azathioprine and Glucoocorticoid. Furthermore, the 5-gene model may suggest antagonism to IFX and prognosis for colon cancer associated with inflammatory bowel disease. Single-cell sequencing targeting T cell-related features in patients with Crohn’s disease may aid in new diagnostic decisions, as well as the initial exploration of high-potential therapies.

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“…In addition, TL1A helps balance promotion and inhibition of the inflammatory response in the intestinal mucosa in CD. At the initial stage of inflammation, when T cells are recruited to the inflammatory site of intestinal mucosa, TL1A interacts with DR3 to enhance inflammatory cytokine secretion, and these cytokines cause the recruitment and activation of macrophages and neutrophils, stimulating further inflammation[ 51 ].…”

Section: Susceptibility Genesmentioning

confidence: 99%

Research progress on the relationship between Paneth cells-susceptibility genes, intestinal microecology and inflammatory bowel disease

Zhou,

Zheng

2023

World J Clin Cases

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Inflammatory bowel disease (IBD) is a disorder of the immune system and intestinal microecosystem caused by environmental factors in genetically susceptible people. Paneth cells (PCs) play a central role in IBD pathogenesis, especially in Crohn's disease development, and their morphology, number and function are regulated by susceptibility genes. In the intestine, PCs participate in the formation of the stem cell microenvironment by secreting antibacterial particles and play a role in helping maintain the intestinal microecology and intestinal mucosal homeostasis. Moreover, PC proliferation and maturation depend on symbiotic flora in the intestine. This paper describes the interactions among susceptibility genes, PCs and intestinal microecology and their effects on IBD occurrence and development.

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Gene/environment interaction in the susceptibility of Crohn's disease patients to aluminum

Cited by 7 publications

References 46 publications

Jian-Pi-Yin decoction attenuates lactose-induced chronic diarrhea in rats by regulating GLP-1 and reducing NHE3 ubiquitination and phosphorylation

Jian-Pi-Yin decoction attenuates lactose-induced chronic diarrhea in rats by regulating GLP-1 and reducing NHE3 ubiquitination and phosphorylation

Single-Cell Sequencing-Based Validation of T Cell-Associated Diagnostic Model Genes and Drug Response in Crohn’s Disease

Research progress on the relationship between Paneth cells-susceptibility genes, intestinal microecology and inflammatory bowel disease

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