Gene-Environment Interaction between TLR4 Gene and Mold Exposure in Infancy on the Development of Allergic Rhinitis in School-Aged Children

Kim, H.; Seo, Ju‐Hee; Lee, S.; Kang, Mi‐Jin; Kwon, Ji‐Won; Kim, B.; Song, Young Woo; Kim, Y.; Hong, Soo‐Jong

doi:10.1016/j.jaci.2011.12.541

Cited by 2 publications

(5 citation statements)

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“…There is a caveat, however, in that anti-CD90 mAb also depletes NK cells in rag2 −/− mice. In addition, NH cells play a major role in airway hypersensitivity induced by glycolipid antigen (Kim et al, 2012) or papain (Halim et al, 2012). Similarly, nuocytes were reported to play a role in airway hypersensitivity induced by intranasal administration of IL-25 or IL-33 in il4/il13 dual reporter mice (Barlow et al, 2011).…”

Section: Th2-type Innate Lymphocytes and Allergic Inflammationmentioning

confidence: 99%

Role of Innate Lymphocytes in Infection and Inflammation

Koyasu

Moro

2012

Front. Immun.

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Cooperation between the innate and adaptive immune responses is critical for enabling protective immunity against various invading microbes. Distinct types of effector T cells have different functions in adaptive immune responses. Th1 cells play important roles in the control of intracellular bacteria by producing IFN-γ to activate macrophages and in anti-viral immunity by producing IFN-γ and activating cytotoxic T lymphocytes. Th2 cell-derived cytokines are important in activating mast cells, eosinophils, and goblet cells in anti-helminth immunity. Th17 cells are pivotal for the inflammatory response mediated by neutrophils, which resists extracellular bacterial infection. In all cases, it is critical that the innate immune responses limit the growth and expansion of invading microbes until antigen-specific adaptive immune responses are established. Recent studies have identified multiple subsets in innate lymphocytes corresponding to previously defined Th subsets. Classical natural killer cells, RORγ+ lymphoid tissue inducer-related cells, and Th2-type innate lymphocytes play distinct roles in innate immune responses by producing Th1, Th17, and Th2 cytokines, respectively. Cooperation between innate lymphocytes and antigen-specific T and B cells are likely important in protective immunity against distinct types of microbes. The most recently identified subset is the RORγ-independent Lin−Thy-1+IL-7R+GATA3+ innate lymphocyte subset such as natural helper (NH) cell, which is Id2- and IL-7-dependent. This population produces Th2 cytokines, most notably IL-5 and IL-13, and plays a major role in innate immune responses during anti-helminth immunity. In addition, these cells are likely involved in the pathophysiology of some types of allergic diseases. We summarize here current knowledge regarding various innate lymphocyte subsets. In particular, we focus on the Th2-type innate lymphocyte subset.

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Section: Th2-type Innate Lymphocytes and Allergic Inflammationmentioning

confidence: 99%

Role of Innate Lymphocytes in Infection and Inflammation

Koyasu

Moro

2012

Front. Immun.

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“…Lymphocyte subsets capable of responding to IL-33 include Th2 cells, a small population of IL-4-independent atypical Th2 cells (Xu et al, 1998; Kurowska-Stolarska et al, 2008), activated CD8 + T cells (Yang et al, 2011; Bonilla et al, 2012), B-1 B cells (Komai-Koma et al, 2011), and NKT cells (Smithgall et al, 2008; Bourgeois et al, 2009; Chen et al, 2012; Kim et al, 2012a). IL-33 stimulates conventional Th2 cells to release IL-4, IL-5, and IL-13 and IL-33-driven Th2 cells profoundly inhibit atherosclerosis (Miller et al, 2008).…”

Section: Targets Of Il-33mentioning

confidence: 99%

“…Similar activity is observed of IL-33 in NKT cells, whose secretion of IFN-γ is induced by IL-33 either alone or in combination with TCR stimulation or IL-12 (Smithgall et al, 2008; Bourgeois et al, 2009). In an airway hypersensitivity model, antigen-stimulated NKT cells induced production of IL-33 by alveolar macrophages, CD11c + dendritic cells and type II pneumocytes, which in turn activated NKT cells to produce IL-13 (Kim et al, 2012a). …”

Section: Targets Of Il-33mentioning

confidence: 99%

“…For example, RNA derived from the influenza virus induces the secretion of IL-33 by alveolar macrophages through TLR7 activation (Chang et al, 2011). Macrophages secrete IL-33 following action by NKT cells and this in turn increases the production of IL-13 by NKT cells and ILC2s (Kim et al, 2012a). Finally, unidentified lung stromal cells were shown to release IL-33 after stimulation of protease-activated receptors with protease allergen papain (Halim et al, 2012).…”

Section: Regulation Of Inflammation By Il-33mentioning

confidence: 99%

“…A typical mechanism of IL-33 action on inflammation is to induce the production of additional inflammatory mediators. An IL-33 target cell that has recently received great attention is ILC2 which plays a critical role in Th2 inflammation by secreting IL-5 and IL-13 (Chang et al, 2011; Bartemes et al, 2012; Kim et al, 2012a). IL-5 and IL-13 induce airway eosinophilia and hypersensitivity responses, respectively.…”

Section: Regulation Of Inflammation By Il-33mentioning

confidence: 99%

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Interleukin-33: A Mediator of Inflammation Targeting Hematopoietic Stem and Progenitor Cells and Their Progenies

Kim

et al. 2013

Front. Immunol.

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Inflammation is defined as a physiological response initiated by a variety of conditions that cause insult to the body, such as infection and tissue injury. Inflammation is triggered by specialized receptors in the innate immune system, which recognize microbial components known as pathogen-associated molecular patterns or endogenous signals produced by damaged cells (damage-associated molecular patterns). IL-33 is a cytokine that is released predominantly at the epithelial barrier when it is exposed to pathogens, allergens, or injury-inducing stimuli. IL-33 target cells are various, ranging from hematopoietic stem and progenitor cells (HSPCs) and essentially all types of their progeny to many non-hematopoietic cells. The pleiotropic actions of IL-33 suggest that IL-33 is involved in every phase of the inflammatory process. In this review, we discuss recent advances in the understanding of how IL-33 orchestrates inflammatory responses by regulating HSPCs and innate immune cells.

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Gene-Environment Interaction between TLR4 Gene and Mold Exposure in Infancy on the Development of Allergic Rhinitis in School-Aged Children

Cited by 2 publications

References 0 publications

Role of Innate Lymphocytes in Infection and Inflammation

Role of Innate Lymphocytes in Infection and Inflammation

Interleukin-33: A Mediator of Inflammation Targeting Hematopoietic Stem and Progenitor Cells and Their Progenies

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