Gene-environment interaction and psychiatric disorders: Review and future directions

Assary, Elham; Vincent, John P.; Keers, Robert; Pluess, Michael

doi:10.1016/j.semcdb.2017.10.016

Cited by 227 publications

(124 citation statements)

References 143 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…As was also concluded by a recent meta-analysis [105], an association between the COMT Val158Met genotype, cannabis use, and psychosis cannot be proven at the moment, accounting for the dissimilarity in results. These controversial results probably reflect the limited value of the study of single genes for predicting mental health outcomes [106,107], since complex phenotypes like psychosis are associated with multiple genes [108]. Over the past decade, advanced genetic analyses that allow complex phenotypes to be predicted have been developed, such as polygenic risk scores [109].…”

Section: Discussionmentioning

confidence: 99%

Factors Moderating the Association between Cannabis Use and Psychosis Risk: A Systematic Review

2020

View full text Add to dashboard Cite

Increasing evidence indicates a relationship between cannabis use and psychosis risk. Specific factors, such as determinants of cannabis use or the genetic profile of cannabis users, appear to moderate this association. The present systematic review presents a detailed and up-to-date literature overview on factors that influence the relationship between cannabis use and psychosis risk. A systematic search was performed according to the PRISMA guidelines in MEDLINE and Embase, and 56 studies were included. The results show that, in particular, frequent cannabis use, especially daily use, and the consumption of high-potency cannabis are associated with a higher risk of developing psychosis. Moreover, several genotypes moderate the impact of cannabis use on psychosis risk, particularly those involved in the dopamine function, such as AKT1. Finally, cannabis use is associated with an earlier psychosis onset and increased risk of transition in individuals at a clinical high risk of psychosis. These findings indicate that changing cannabis use behavior could be a harm reduction strategy employed to lower the risk of developing psychosis. Future research should aim to further develop specific biomarkers and genetic profiles for psychosis, thereby contributing to the identification of individuals at the highest risk of developing a psychotic disorder.

show abstract

Section: Discussionmentioning

confidence: 99%

Factors Moderating the Association between Cannabis Use and Psychosis Risk: A Systematic Review

2020

View full text Add to dashboard Cite

show abstract

“…In other fields, GWEIS are being undertaken and are starting to be used in PD . GWEIS consider gene–environment interaction on a whole‐genome basis and assess associations between an environmental exposure and each SNP individually.…”

Section: The Next 10 Yearsmentioning

confidence: 99%

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

2019

View full text Add to dashboard Cite

There is evidence from observational studies for a role of a number of environmental exposures and lifestyle habits in modulating the risk for Parkinson's disease. Environmental and lifestyle associations, if causal, represent opportunities for Parkinson's disease prevention or disease modification at individual and population levels. In the past decade, additional evidence has been published that improves causal inference and/or enhances our understanding of the complexity of these associations. A number of gene–environment interactions have been elucidated, and our understanding of the roles of physical activity, pesticide and other chemical exposures, dietary habits, emotional stress, head injury, and smoking has been refined. In the next decade, better techniques will help us to close the gaps in our knowledge, including taking into account Parkinson's disease heterogeneity and gene and risk factor interactions in observational studies. To do this, larger datasets, global consortia, genomewide environment interaction studies, prospective studies throughout the lifespan, and improvements in the methodology of clinical trials of physical activity will be key. Despite the caveats of observational studies, a number of low‐risk and potentially high‐yield recommendations for lifestyle modification could be made to minimize the individual and societal burdens of Parkinson's disease, including dietary modifications, increasing physical activity, and head injury avoidance. Furthermore, a reduction in pesticide use could have a major impact on global health related to and beyond Parkinson's disease. Given the increasing prevalence of this disorder, formulating and promoting these recommendations should be a high priority. © 2019 International Parkinson and Movement Disorder Society

show abstract

“…Research on the genetic and environmental aetiologies of SPS is still in its infancy. As candidate gene studies have been criticised for their reliance on a priori assumptions about the biological function of specific genes, which is limited at present (Assary, Vincent, Keers, & Pluess, 2017), a multi-pronged approach is needed to investigate the aetiology underlying SPS. Also, common and complex phenotypes, such as SPS, are expected to result from multiple genetic variants of small effect size (Flint & Munafò, 2013), as well as from synergistic interactions with the environment .…”

Section: Future Directionsmentioning

confidence: 99%

Sensory Processing Sensitivity in the Context of Environmental Sensitivity: A Critical Review and Development of Research Agenda

Greven

Lionetti

Booth

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

Sensory Processing Sensitivity (SPS) is a trait describing inter-individual differences in sensitivity to environments, both positive and negative ones. SPS has attracted growing societal interest. However, (neuro)scientific evidence is lagging behind. We critically discuss how to measure SPS, how it relates to other theories of Environmental Sensitivity and other temperament and personality traits, how SPS interacts with environments to influence (a)typical development, what the underlying aetiologies and mechanisms are, and its relation to mental disorders involving sensory sensitivities. Drawing on the diverse expertise of the authors, we set an agenda for future research to stimulate the field. We conclude that SPS is a heritable, evolutionarily conserved trait, linked to increased risk for psychopathology and stress-related problems in response to negative environments, as well as to greater benefits (e.g., intervention responsivity, positive mood) in positive environments. We need advances in objective assessment of SPS, understanding mechanisms, differentiating it from (seemingly) related mental disorders, to exploit the potential of SPS to improve mental health, preserve human capital, and prevent adverse effects.

show abstract

Gene-environment interaction and psychiatric disorders: Review and future directions

Cited by 227 publications

References 143 publications

Factors Moderating the Association between Cannabis Use and Psychosis Risk: A Systematic Review

Factors Moderating the Association between Cannabis Use and Psychosis Risk: A Systematic Review

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

Sensory Processing Sensitivity in the Context of Environmental Sensitivity: A Critical Review and Development of Research Agenda

Contact Info

Product

Resources

About