Gene delivery based on macrocyclic amphiphiles

Geng, Wen‐Chao; Huang, Qiaoxian; Xu, Zhe; Wang, Ruibing; Guo, Dong‐Sheng

doi:10.7150/thno.31914

Cited by 49 publications

(45 citation statements)

References 120 publications

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“…Some CAs are able to denature DNA by complexation and can therefore be used to develop antibacterial and/or anticancer drugs [126] . Importantly, certain CAs exhibit transfection ability, especially those modified with guanidinium, tetraalkylammonium, and amino groups [121d, 127] …”

Section: Gene Delivery and Transfectionmentioning

confidence: 99%

Biomedical Applications of Calixarenes: State of the Art and Perspectives

2020

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Calixarenes (CAs), representing the third generation of supramolecular hosts and one of the most widely studied macrocyclic scaffolds, offer (almost) unlimited structure and application possibilities due to their ease of modification, which allows one to establish a large molecular library as a material basis for diverse biomedical applications. Moreover, CAs and their derivatives engage in various noncovalent interactions for the facile recognition of guests including bioactive molecules and are also important building blocks for the fabrication of supramolecular architectures. In view of their molecular recognition and self‐assembly properties, CAs are extensively applied in biosensing, bioimaging, and drug/gene delivery. Additionally, some CA derivatives exhibit biological activities and can therefore be used as new therapeutic agents. Herein, we summarize the diverse biomedical applications of CAs including in vitro diagnosis (biosensing), in vivo diagnosis (bioimaging), and therapy.

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Section: Gene Delivery and Transfectionmentioning

confidence: 99%

Biomedical Applications of Calixarenes: State of the Art and Perspectives

2020

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“…Most nonviral nucleid acid carriers (vectors) reported are polymeric, conformationally undefined or complex nanoparticulate materials [ 85 ]. In the last decade, however, multivalent polycations based on molecular systems emerged as a promising alternative [ 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 ]. Polycationic cyclodextrins have become the iconic representatives in this category [ 5 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 ].…”

Section: Biomacromolecule-templated Formation Of Functional Glycocmentioning

confidence: 99%

Cyclodextrin-Based Functional Glyconanomaterials

2020

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Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools to manipulate the pharmacokinetics of a broad range of active principles, due to their unique combination of biocompatibility and inclusion abilities. The development of precision chemical methods for their selective functionalization, in combination with “click” multiconjugation procedures, have further leveraged the nanoscaffold nature of these oligosaccharides, creating a direct link between the glyco and the nano worlds. CDs have greatly contributed to understand and exploit the interactions between multivalent glycodisplays and carbohydrate-binding proteins (lectins) and to improve the drug-loading and functional properties of nanomaterials through host–guest strategies. The whole range of capabilities can be enabled through self-assembly, template-assisted assembly or covalent connection of CD/glycan building blocks. This review discusses the advancements made in this field during the last decade and the amazing variety of functional glyconanomaterials empowered by the versatility of the CD component.

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“…Einige CAs sind in der Lage DNA durch Komplexierung zu denaturieren und können daher zur Entwicklung von antibakteriellen Wirkstoffen und/oder Krebsmedikamenten verwendet werden [126] . Wichtig ist, dass bestimmte CAs eine Transfektionsfähigkeit aufweisen, insbesondere solche, die mit Guanidinium‐, Tetraalkylammonium‐ und Aminogruppen modifiziert wurden [121d, 127] …”

Section: Genabgabe Und Transfektionunclassified

Biomedizinische Anwendungen von Calixarenen: Stand der Wissenschaft und Perspektiven

Pan

Guo

2020

Angewandte Chemie

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Calixarene (CAs) stellen die dritte Generation supramolekularer Wirtsstrukturen dar und sind eine der am häufigsten untersuchten makrocyclischen Gerüststrukturen. Sie bieten aufgrund ihrer einfachen Modifikation (fast) unbegrenzte Möglichkeiten, um große Molekülbibliotheken als Materialbasis für vielfältige biomedizinische Anwendungen zu etablieren. Darüber hinaus beteiligen sich CAs und ihre Derivate an verschiedenen nichtkovalenten Interaktionen zur einfachen Erkennung von Gaststrukturen, einschließlich bioaktiver Moleküle, und sind auch wichtige Bausteine für die Herstellung supramolekularer Architekturen. Im Hinblick auf ihre molekularen Erkennungs‐ und Selbstorganisationseigenschaften werden CAs in großem Umfang in der Biosensorik, dem Bioimaging und im Wirkstoff‐/Gentransport eingesetzt. Weiterhin weisen einige CA‐Derivate biologische Aktivitäten auf und können daher als neue Therapeutika eingesetzt werden. Wir fassen hier die vielfältigen biomedizinischen Anwendungen von CAs zusammen, einschließlich der In‐vitro‐Diagnostik (Biosensorik), In‐vivo‐Diagnostik (Bioimaging) und Therapie.

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Gene delivery based on macrocyclic amphiphiles

Cited by 49 publications

References 120 publications

Biomedical Applications of Calixarenes: State of the Art and Perspectives

Biomedical Applications of Calixarenes: State of the Art and Perspectives

Cyclodextrin-Based Functional Glyconanomaterials

Biomedizinische Anwendungen von Calixarenen: Stand der Wissenschaft und Perspektiven

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