Gene count normalization in single-cell imaging-based spatially resolved transcriptomics
Lyla Atta,
Kalen Clifton,
Manjari Anant
et al.
Abstract:Background
Recent advances in imaging-based spatially resolved transcriptomics (im-SRT) technologies now enable high-throughput profiling of targeted genes and their locations in fixed tissues. Normalization of gene expression data is often needed to account for technical factors that may confound underlying biological signals.
Results
Here, we investigate the potential impact of different gene count normalization methods with different targeted ge… Show more
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