Gene copy numbers of erbB oncogenes in human pheochromocytoma

Sworczak, Krzysztof; Żaczek, Anna; Babińska, Anna; Lisowska, Urszula; Bielawski, Krzysztof; Falkiewicz, Bogdan

doi:10.3892/or.9.6.1373

Cited by 6 publications

(7 citation statements)

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“…found that high ERBB2 immunostaining positivity in phaeochromocytoma showed a malignant behaviour. This phenomenon was also observed by our study and several other studies . However, de Krijger et al .…”

Section: Discussionsupporting

confidence: 93%

Gene expression profiles of phaeochromocytomas with ERBB2 overexpression reveal a new molecular mechanism tumourigenicity

Xia

et al. 2012

Clinical Endocrinology

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Section: Discussionsupporting

confidence: 93%

Gene expression profiles of phaeochromocytomas with ERBB2 overexpression reveal a new molecular mechanism tumourigenicity

Xia

et al. 2012

Clinical Endocrinology

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“…The studies on receptors in ErbB family showed a connection between their detectable expression and the incidence of malignant or family PHEO types. However, the results of this research is still ambiguous [24,25] .…”

Section: Introductionmentioning

confidence: 98%

The Role of Immunohistochemistry in Histopathological Diagnostics of Clinically “Silent” Incidentally Detected Adrenal Masses

Babińska

Sworczak²,

Wiśniewski³

et al. 2008

Exp Clin Endocrinol Diabetes

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We found a statistically significant correlation between the expression of p53, p21, Ki67 and the differential diagnosis of adrenal cortical adenoma and adrenocortical carcinoma (for proteins: p53 p=0.010, for p21 p=0.010, for Ki67 p<0.001). The statistical significant correlation between PCNA protein and diagnosis of adrenal cortical adenoma and adrenocortical carcinoma was not found. The statistically significant correlation between p21, PCNA proteins and the diagnosis of benign and malignant PHEOs was not estimated. There was no expression of Ki67 or p53 protein above the assumed level in benign and malignant pheochromocytomas. The statistically significant correlation between p53, p21, PCNA or Ki67 and the occurrence of metastases in adrenocarcinoma and malignant PHEOs was not found.

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“…We did not find any relationship between these amplifications and other clinical parameters. The deletions of the ErbB-2/Her-2 gene found in two cases are not common in any type of tumours where mainly amplifications play an important role in carcinogenesis and are a prognostic factor (Sworczak et al, 2002;Xu et al, 2002;Awaya et al, 2005;Freundenberg et al, 2005).…”

Section: Discussionmentioning

confidence: 96%

“…ErbB/ Her genes are often mutated or have altered expression in cancer and precancerous cells, which is often a sign of progression and development of disease (Vogt et al, 1998;Xu et al, 2002;Awaya et al, 2005;Saxby et al, 2005;Sassen et al, 2008). ErbB/Her aberrations have also been reported in some types of endocrine lesions, e.g., of thyroid, pheochromocytoma and pancreas (Sworczak et al, 2002;Freudenberg et al, 2005;Saxby et al, 2005;Lee et al, 2007). ErbB-1/Her-1/EGFR expression has been found in pHPT-related adenomas and hyperplasia (Sadler et al, 1996;Gülkesen et al, 2001) and, interestingly, recent data have documented an involvement of its activation in the initiation of parathyroid hyperplasia as a consequence of secondary hyperparathyroidism (Cozzolino et al, 2005).…”

Section: Sporadicmentioning

confidence: 99%

The profile of ErbB/Her family genes copy number assessed by real-time PCR in parathyroid adenoma and hyperplasia associated with sporadic primary hyperparathyroidism.

Bednarz¹,

Błaut²,

Sworczak³

et al. 2009

Acta Biochim Pol

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Hyperparathyroidism (pHPT) is a relatively frequent endocrinopathy, however, the molecular mechanisms of its etiology remain poorly understood. This disorder is mainly associated with benign tumours (adenoma) and hyperplasia of the parathyroid, hence, the focus is directed also to genes that are likely to be involved in carcinogenesis. Among such genes are ErbB/Her family genes already used in diagnosis of other tumours (e.g., breast carcinoma) and reported also to play a role in development of endocrine lesions. So far, ErbB-1/Her-1/EGFR expression has been detected in pHPT-associated adenomas and hyperplasia as opposed to no expression in normal parathyroid tissue. Moreover, losses or gains of the fragments of chromosomes where ErbB/Her genes are located have been reported. In this study, the gene dosage of ErbB/Her family genes were determined for the first time in parathyroid adenomas, hyperplasia and morphologically unchanged tissue in order to establish their putative role in the development of the disease. Genomic DNA was isolated from 33 patients with sporadic hyperparathyroidism and the gene copy numbers were assessed using real-time PCR. The ErbB/Her genes' profile was unaltered in most of the examined samples. Two low-level amplifications of ErbB-1/Her-1/EGFR gene, two deletions of ErbB-2/Her-2, and six deletions of ErbB-4/Her-4 were found. The ErbB-3/Her-3 gene remained unaffected. No correlation with clinical parameters was found for any gene. Both the low number of alterations and a lack of their associations with clinical parameters exclude the prognostic value of the ErbB/Her genes family in parathyroid tumourigenesis. Nevertheless, the ErbB-4/Her-4 deletions seem to be interesting for further investigations, especially in the context of PTH secretion.

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Gene copy numbers of erbB oncogenes in human pheochromocytoma

Cited by 6 publications

References 0 publications

Gene expression profiles of phaeochromocytomas with ERBB2 overexpression reveal a new molecular mechanism tumourigenicity

Gene expression profiles of phaeochromocytomas with ERBB2 overexpression reveal a new molecular mechanism tumourigenicity

The Role of Immunohistochemistry in Histopathological Diagnostics of Clinically “Silent” Incidentally Detected Adrenal Masses

The profile of ErbB/Her family genes copy number assessed by real-time PCR in parathyroid adenoma and hyperplasia associated with sporadic primary hyperparathyroidism.

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