Gene Conversion may aid Adaptive Peak Shifts

Hansen, Thomas F.; Carter, Ashley J. R.; Chiu, Chi-hua

doi:10.1006/jtbi.2000.2189

Cited by 24 publications

(17 citation statements)

References 51 publications

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“…Recent simulations indicate rapid shifts to alternative adaptive optima are feasible through the uncovering of genetic variation buffered via networks. (19) Unlike these mechanisms, (19,65) release of Hsp90-buffered variation is a genome-wide phenomenon linked to stressful environmental conditions. The buffered variation is released precisely under those challenging conditions when selection is most stringent and novelty might be most beneficial.…”

Section: More Hsp90-better Buffering?mentioning

confidence: 98%

“…Another mechanism posits the neutral accumulation of variation in a non-functionalized copy of a duplicated gene. (65) This variation is then transmitted to the functional copy by gene conversion, simultaneously exposing multiple polymorphisms. Recent simulations indicate rapid shifts to alternative adaptive optima are feasible through the uncovering of genetic variation buffered via networks.…”

Section: More Hsp90-better Buffering?mentioning

confidence: 99%

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Under cover: causes, effects and implications of Hsp90‐mediated genetic capacitance

2004

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The environmentally responsive molecular chaperone Hsp90 assists the maturation of many key regulatory proteins. An unexpected consequence of this essential biochemical function is that genetic variation can accumulate in genomes and can remain phenotypically silent until Hsp90 function is challenged. Notably, this variation can be revealed by modest environmental change, establishing an environmentally responsive exposure mechanism. The existence of diverse cryptic polymorphisms with a plausible exposure mechanism in evolutionarily distant lineages has implications for the pace and nature of evolutionary change. Chaperone-mediated storage and release of genetic variation is undoubtedly rooted in protein-folding phenomena. As we discuss, proper protein folding crucially affects the trajectory from genotype to phenotype. Indeed, the impact of protein quality-control mechanisms and other fundamental cellular processes on evolution has heretofore been overlooked. A true understanding of evolutionary processes will require an integration of current evolutionary paradigms with the many new insights accruing in protein science.

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Section: More Hsp90-better Buffering?mentioning

confidence: 98%

Section: More Hsp90-better Buffering?mentioning

confidence: 99%

Under cover: causes, effects and implications of Hsp90‐mediated genetic capacitance

2004

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Section: Capacitymentioning

confidence: 99%

Perspective:evolution and Detection of Genetic Robustness

Visser

Hermisson

Wagner

et al. 2003

Evol

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340

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Abstract. -Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein level to behavior at the organismal level. Phenotypes can be robust either against heritable perturbations (e.g. mutations) or non-heritable perturbations (e.g. the weather). Here we primarily focus on the first kind of robustness -genetic robustness -and survey three growing avenues of research: (1) measuring genetic robustness in nature and in the laboratory, (2) understanding the evolution of genetic robustness, and (3) exploring the implications of genetic robustness for future evolution.

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“…Such variation may be the fuel for further evolution. If environmental perturbations are merely transient, however, increased evolvability will only be ensured if the production of variation becomes independent of environmental inputs (for a discussion of the contribution of hide-and-release mechanisms of genetic variation to evolvability see Hansen et al 2000). Waddington (1953) observed the release of hidden variation followed by adaptive evolution in Drosophila cross-vein formation, and called this seemingly Lamarckian phenomenon ''genetic assimilation.''…”

Section: Capacitymentioning

confidence: 99%

Perspective: Evolution and Detection of Genetic Robustness

et al. 2003

Self Cite

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Abstract. Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein level to behavior at the organismal level. Phenotypes can be robust either against heritable perturbations (e.g., mutations) or nonheritable perturbations (e.g., the weather). Here we primarily focus on the first kind of robustness-genetic robustness-and survey three growing avenues of research: (1) measuring genetic robustness in nature and in the laboratory; (2) understanding the evolution of genetic robustness; and (3) exploring the implications of genetic robustness for future evolution.

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Gene Conversion may aid Adaptive Peak Shifts

Cited by 24 publications

References 51 publications

Under cover: causes, effects and implications of Hsp90‐mediated genetic capacitance

Under cover: causes, effects and implications of Hsp90‐mediated genetic capacitance

Perspective:evolution and Detection of Genetic Robustness

Perspective: Evolution and Detection of Genetic Robustness

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