Gene conversion-like mechanisms may generate polymorphism in human class I genes.

Seemann, G.; Rein, Reet; Brown, Colin B.; Ploegh, Hidde L.

doi:10.1002/j.1460-2075.1986.tb04245.x

Cited by 88 publications

(28 citation statements)

References 12 publications

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“…USA 87 (1990) translated region (25,26) is truly a locus-specific marker in these sequences. Segmental exchange between HLA loci has been proposed from patterns of sequence shared between alleles at different loci (27)(28)(29). However, clear-cut divergence of sequence between loci in HLA suggests that intralocus exchanges play a more important evolutionary role than interlocus exchanges in generating polymorphism in humans and the higher primates (29,30).…”

Section: L L L L a A A L Ap T Q T R A G S H S L R T Pty T A V Smentioning

confidence: 99%

Concerted evolution of class I genes in the major histocompatibility complex of murine rodents.

Rada

Lorenzi²,

Powis³

et al. 1990

Proc. Natl. Acad. Sci. U.S.A.

118

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Full-length cDNA sequences of two class I major histocompatibility complex molecules from the DA strain of Rattus norvegicus are reported. One codes for the classical class I restriction element RTL.Aa, which maps to the locus in the rat major histocompatibility complex homologous to H-2K in the mouse. The other probably codes for a soluble nonclassical class I molecule present in DA rat serum; a short deletion in the fifth exon implies that the translated product will terminate in the membrane-spanning region. These sequences have been compared with mouse classical class I sequences as well as with three published rat class I cDNA partial sequences. The results show, first, that "locus-specific" substitutions from the H-2K, H-2D, and H-2L data set are scrambled in the RTl.A molecule; a majority of these substitutions have H-2D/L-specific features. Second, the data show that the four rat sequences are strikingly similar to one another regardless of locus or haplotype of origin; they share a number of apparently species-specific features that distinguish them all from mouse classical class I sequences, which likewise share distinctive features of their own. The results suggest that segmental sequence exchange plays a major role in determining the evolution of sequence in class I masjor histocompatibility complex molecules.Some multigene families display a degree of species specificity at the level of DNA sequence, as if the whole family were evolving within a species as a unit (1-3). Such concerted evolution has been suspected in mouse major histocompatibility complex (MHC) class I genes because of the lack of clear locus-specific sequence variation distinguishing the widely separated H-2K and H-2D end classical loci (4, 5). Short segmental exchanges of sequence are indeed occurring between widely separated class I MHC loci in laboratory mice (6). Nevertheless it remains controversial whether such processes contribute significantly to the pattern of evolution of class I genes (7), since sequences of class I genes from a closely related murine species such as the rat are not yet available. Rattus norvegicus is in the same subfamily, the Murinae, as the mouse. The rat MHC, RTI, is like H-2 in structure, with a classical class I gene, RTJ.A, at the left end of the MHC in the same location as H-2K and a long array of other class I genes to the right (8). In the middle is a region specifying class II genes that closely resembles the homologous region of H-2 (9). It is most likely that the translocation of class I genes that formed the H-2K end was a unique event occurring shortly before the separation of the rat and mouse lineages (7). Rat class I gene sequences thus provide a stringent test of the concerted evolution hypothesis. With simple divergent evolution alone, the sequence of an RTI.A allele should have greater similarity to H-2K on average than to other rat class I sequences, since RTI.A and H-2K share a more recent common ancestor than either does with genes at the other end of the MHC. If, on the ot...

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Section: L L L L a A A L Ap T Q T R A G S H S L R T Pty T A V Smentioning

confidence: 99%

Concerted evolution of class I genes in the major histocompatibility complex of murine rodents.

Rada

Lorenzi²,

Powis³

et al. 1990

Proc. Natl. Acad. Sci. U.S.A.

118

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“…The HLA-A3/A9 allele might be 20 We noted some nucleotide differences in exon II and IV but none which would result in amino acid differences. We also found sequence differences within intron I and II when compared with previously published sequences for non-diseased HLA-B*2705 alleles.…”

Section: Discussionmentioning

confidence: 72%

“…We also found sequence differences within intron I and II when compared with previously published sequences for non-diseased HLA-B*2705 alleles. 16 20 24 Clearly, further studies are required to resolve the problem of the association of HLA-B27 with AS.…”

Section: Discussionmentioning

confidence: 99%

Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis

1993

Ann Rheum Dis

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“…Although the strength of the association of the HLA-B27 antigen and AS renders the HLA-B27 gene unique among the class I gene family, the HLA-B27 gene was only recently isolated. Several groups have cloned HLA-B27 gene sequences (see Table I) [4][5][6][7] and the amino acid sequences of four HLA-B27 Subtypes have also been obtained by protein sequencing [8][9][10][11]. The gene Organization has been determined by isolating cDNA and genomic cosmid clones [4,5] from gene libraries construeted of DNA prepared from peripheral white blood cells (PBL) and of RNA isolated from a homozygous B-cell line (B LCL) of persons with no history of disease.…”

mentioning

confidence: 99%

“…The gene Organization has been determined by isolating cDNA and genomic cosmid clones [4,5] from gene libraries construeted of DNA prepared from peripheral white blood cells (PBL) and of RNA isolated from a homozygous B-cell line (B LCL) of persons with no history of disease. Seemann et al [6] reported two HLA-B27 subtype sequences cloned from a B-cell line (HLA-B27.1/27.2) which differ only by four nucleotides resulting in three amino acid exchanges. All HLA-B27 sequences are identical in the protein coding regions, the differences found in the LG2-cDNA sequence being due to cDNA cloning artefacts.…”

mentioning

confidence: 99%

Molecular Biology of the HLA-B27 Locus

Weiß¹,

Bloemer²,

Doerner³

et al. 1988

Rheumatology

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Gene conversion-like mechanisms may generate polymorphism in human class I genes.

Cited by 88 publications

References 12 publications

Concerted evolution of class I genes in the major histocompatibility complex of murine rodents.

Concerted evolution of class I genes in the major histocompatibility complex of murine rodents.

Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis

Molecular Biology of the HLA-B27 Locus

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