Gene control of mammalian pigmentary differentiation. I. Clonal origin of melanocytes.

Mintz, Beatrice

doi:10.1073/pnas.58.1.344

Cited by 222 publications

(121 citation statements)

References 5 publications

(2 reference statements)

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“…In this study we targeted the region around the tyrosinase locus ( Tyr) because the arrangements in this region should be non‐lethal and Tyr provides the ability to score re‐arrangements phenotypically (Deol et al ., 1986; Le Fur et al ., 1996; Mintz, 1967). The zygotes used in this study were C57BL6/N, thus homozygous loss‐of‐function mutations will be readily visible as albino fur (Supporting Information Fig.…”

Section: Resultsmentioning

confidence: 99%

Chromosome engineering in zygotes with CRISPR/Cas9

Boroviak

Doe

Banerjee

et al. 2016

Genesis

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SUMMARYDeletions, duplications, and inversions of large genomic regions covering several genes are an important class of disease causing variants in humans. Modeling these structural variants in mice requires multistep processes in ES cells, which has limited their availability. Mutant mice containing small insertions, deletions, and single nucleotide polymorphisms can be reliably generated using CRISPR/Cas9 directly in mouse zygotes. Large structural variants can be generated using CRISPR/Cas9 in ES cells, but it has not been possible to generate these directly in zygotes. We now demonstrate the direct generation of deletions, duplications and inversions of up to one million base pairs by zygote injection. genesis 54:78–85, 2016. © 2016 The Authors. genesis Published by Wiley Periodicals, Inc.

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Section: Resultsmentioning

confidence: 99%

Chromosome engineering in zygotes with CRISPR/Cas9

Boroviak

Doe

Banerjee

et al. 2016

Genesis

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“…In mice, it was demonstrated that in early embryonic development melanoblast precursor cells arrange themselves along the neural crest after which these cells migrate in a pattern analogous to the Blaschko lines. Each band of the characteristic pattern represents a clone from one single melanoblast [Mintz, 1967;Huszar et al, 1991]. Jackson suggested mosaicism as an underlying cause for the manifestation of skin disorders along the Blaschko lines [Jackson, 1976].…”

Section: Introductionmentioning

confidence: 99%

Pigmentary mosaicism following the lines of Blaschko in a girl with a double aneuploidy mosaicism: (47,XX,+7/45,X)

Niessen

Jonkman

Muis

et al. 2005

American J of Med Genetics Pt A

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We report on a 6-year-old girl with linear streaks of apparent hypopigmentation and hyperpigmentation following the Blaschko lines, growth retardation, bupthalmos of the left eye, and mild mental retardation. She had a 45,X karyotype in lymphocytes. In cultured fibroblasts a double aneuploidy mosaicism was detected, consisting of a cell line with trisomy for chromosome 7 and a cell line with monosomy for the X-chromosome and no cell line with a normal karyotype. Cutis tricolor or three levels of pigmentation in different skin areas suggested presence of a third, probably normal cell line. Double aneuploidy mosaicism of a cell line with monosomy X and a cell line with trisomy of an autosome is a rare finding. The combination of monosomy X with trisomy of chromosomes 8, 10, 13, 18, and 21 has been reported, but not the combination with trisomy 7. In the 45,X cell line, microsatellite analysis showed loss of the maternal X-chromosome, and presence of a maternal and paternal chromosome 7. The 47,XX,þ7 cell line showed a paternal and a maternal X-chromosome, and a paternal and two identical maternal chromosomes 7. Mechanisms that might explain this double aneuploidy mosaicism are discussed.

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“…In the melanocyte chimeras, coat color patterns tend to distribute themselves in broad transverse bands of color over the head, body and tail of the mice. At the mid-dorsal line there appears to be a sharp discontinuity, so that each side appears to be independently determined (Mintz, 1967). Mintz (1967Mintz ( , 1970Mintz ( , 1971b Hair follicle chimeras, like melanocyte chimeras, show transverse bands, with a mid-dorsal discontinuity, except the bands are of a much finer nature (Mintz, 1970(Mintz, , 1971b.…”

Section: In Allophenic Mice Chimerism Can Exist At the Level Of Indimentioning

confidence: 99%

“…At the mid-dorsal line there appears to be a sharp discontinuity, so that each side appears to be independently determined (Mintz, 1967). Mintz (1967Mintz ( , 1970Mintz ( , 1971b Hair follicle chimeras, like melanocyte chimeras, show transverse bands, with a mid-dorsal discontinuity, except the bands are of a much finer nature (Mintz, 1970(Mintz, , 1971b. Coat color in these animals is influenced by the hair follicle itself either through modifying the activity of melanocytes or by altering the structure of the hair (McLaren, 1976).…”

Section: In Allophenic Mice Chimerism Can Exist At the Level Of Indimentioning

confidence: 99%

“…Analysis of serum blocking activity using C57BL/6<->DBA/1 mouse sera and parental spleen white blood cells 204 Table 34. Analysis of serum blocking activity using C57BL/6 <-> A mouse sera and parental spleen white blood cells Other terminology is often used synonymously with allophenic mice (Mintz, 1967). These terms include quadriparental (Mintz, 1965 In conclusion, the phenotypic determination of sex in allophenic mice is influenced by the sex of component strains, and the distribution of these components into the somatic and germ cells of the gonads.…”

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Chimeric drift and immunological tolerance in allophenic mice

Stephens

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Gene control of mammalian pigmentary differentiation. I. Clonal origin of melanocytes.

Cited by 222 publications

References 5 publications

Chromosome engineering in zygotes with CRISPR/Cas9

Chromosome engineering in zygotes with CRISPR/Cas9

Pigmentary mosaicism following the lines of Blaschko in a girl with a double aneuploidy mosaicism: (47,XX,+7/45,X)

Chimeric drift and immunological tolerance in allophenic mice

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