2021
DOI: 10.21203/rs.3.rs-611304/v1
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Gene-Based Association Tests Using GWAS Summary Statistics and Incorporating eQTL

Abstract: Although genome-wide association studies (GWAS) have been successfully applied to a variety of complex diseases and identified many genetic variants underlying complex diseases, there is still a considerable heritability of complex diseases that could not be explained by GWAS. One alternative approach to overcome the missing heritability caused by the genetic heterogeneity is gene-based analysis, which considers the aggregate effects of multiple genetic variants in a single test. Another alternative approach i… Show more

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