Gene and doxorubicin co-delivery system for targeting therapy of glioma

Theranostic GO‐Based Nanohybrid for Tumor Induced Imaging and Potential Combinational Tumor Therapy

“…[ 7 ] Very recently, synergistic or combinational gene/drug therapies have emerged as a promising resolution since this approach could integrate the respective advantages of sharply different therapeutic mechanisms. [8][9][10] For example, the concurrent transport of certain genes into tumor cells can effectively inhibit the multidrug resistance frequently associated with the treatment by anti-tumor drugs. [ 11,12 ] Nevertheless, the majority of available co-delivery DOI: 10.1002/smll.201301613 nanosystems fail to distinguish the diseased cells from the healthy ones, and consequently the non-specifi c biotoxicity risk remains.…”

Specific aptamer-conjugated mesoporous silica–carbon nanoparticles for HER2-targeted chemo-photothermal combined therapy

“…The absorbance of each well was measured by a microplate reader at 450 nm. The therapeutic effect of combining the chemotherapy and photothermal therapy can be evaluated by the combination index (CI) according to previous study [21]. The value of CI <1 indicates synergism, >1 means antagonism, and =1 shows additive effects.…”

Co-delivery of paclitaxel and gemcitabine via CD44-targeting nanocarriers as a prodrug with synergistic antitumor activity against human biliary cancer

“…In particular, combinational chemotherapy using GEM with PTX through multiple specific treatment pathways has synergistically superior therapeutic efficacy, thus reducing intolerable cytotoxicity and maximizing the therapeutic effect even at a lower dose [4e6]. Furthermore, this combination is capable of modulating the genetic barriers of the cancer cell caused by mutation, thereby delaying adjustment to cancer [6,7]. However, co-delivery of GEM and PTX without carriers is often limited by several problems.…”