Gender-Specific Effects on Gestational Length and Birth Weight by Early Pregnancy BPA Exposure

Veiga-López, Almudena; Kannan, Kurunthachalam; Liao, Chunyang; Ye, Wen; Domino, Steven E.; Padmanabhan, Vasantha

doi:10.1210/jc.2015-1724

Cited by 102 publications

(82 citation statements)

References 38 publications

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“…Relationships between these BPA measures and birth outcomes within the MMIP cohort (n=80, including 68 subjects in the present study) have been previously reported (27). …”

Section: Methodssupporting

confidence: 67%

“…Plasma levels of unconjugated BPA (uBPA) and BPA glucuronide (gBPA) were previously measured following collection and analysis methods that were developed and validated by four independent laboratories with the purpose of ensuring sensitive and accurate BPA quantification and minimal contamination (27,29). Relationships between these BPA measures and birth outcomes within the MMIP cohort (n=80, including 68 subjects in the present study) have been previously reported (27).…”

Section: Methodsmentioning

confidence: 99%

“…Based on our previously reported associations between maternal BPA levels during pregnancy and size and gestational age of offspring at birth (27), phthalate metabolite and BPA concentrations from the same time period (first trimester or delivery) were entered into regression models together to investigate relationships between co-exposure and birth outcomes. All analyses were performed using SAS version 9.4 (Cary, NC).…”

Section: Methodsmentioning

confidence: 99%

“…In addition, because we recently found associations between first trimester maternal plasma bisphenol A (BPA) concentrations and lower birth weight in female offspring within this same study population (27), we aimed to investigate relationships between co-exposure to BPA and phthalates during pregnancy and birth outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis

Watkins

Milewski

Domino

et al. 2016

Reproductive Toxicology

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Epidemiologic studies of in utero phthalate exposure and birth outcomes have had conflicting findings. The objective of this study was to characterize maternal phthalate exposure across pregnancy, examine associations between maternal phthalate levels and infant size and gestational age at birth, and investigate relationships between concurrent bisphenol A (BPA) and phthalate exposure and birth outcomes. Women in the Michigan Mother-Infant Pairs cohort provided urine and blood samples during their first trimester and at delivery. Urinary phthalate metabolites and serum BPA were measured at both time points, and birth weight, length, head circumference, and gestational age were recorded from medical records. Maternal DEHP metabolite concentrations were significantly higher at delivery compared to the first trimester (p<0.05), suggesting increased DEHP exposure late in pregnancy. A number of phthalate metabolites were associated with birth size and gestational age in patterns that varied by sex and timing of exposure, independent of BPA exposure.

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“…Relationships between these BPA measures and birth outcomes within the MMIP cohort (n=80, including 68 subjects in the present study) have been previously reported (27). …”

Section: Methodssupporting

confidence: 67%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis

Watkins

Milewski

Domino

et al. 2016

Reproductive Toxicology

Self Cite

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“…Exposure to endocrine disrupting chemicals (EDCs) has been strongly associated with sex-specific effects in both animal models and human epidemiological studies [15–18]. EDCs are chemicals that are capable of interfering with hormone signaling and are found ubiquitously in the environment.…”

Section: Introductionmentioning

confidence: 99%

Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific Epigenetic Reprogramming as a Potential Mechanism

McCabe

Anderson

Montrose

et al. 2017

Curr Envir Health Rpt

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Purpose of review The genetic material of every organism exists within the context of regulatory networks that govern gene expression—collectively called the epigenome. Animal models and human birth cohort studies have revealed key developmental periods that are important for epigenetic programming and vulnerable to environmental insults. Thus, epigenetics represent a potential mechanism through which sexually dimorphic effects of early-life exposures such as endocrine disrupting chemicals (EDCs) manifest. Recent findings Several animal studies, and to a lesser extent human studies, have evaluated life-course sexually dimorphic health effects following developmental toxicant exposures; many fewer studies, however, have evaluated epigenetics as a mechanism mediating developmental exposures and later outcomes. Summary To evaluate epigenetic reprogramming as a mechanistic link of sexually dimorphic early-life EDCs exposures, the following criteria should be met: 1) well characterized exposure paradigm that includes relevant windows for developmental epigenetic reprogramming; 2) evaluation of sex-specific exposure-related epigenetic change; and 3) observation of a sexually dimorphic phenotype in either childhood, adolescence, or adulthood.

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Developmental programming: Interaction between prenatal BPA and postnatal overfeeding on cardiac tissue gene expression in female sheep

Koneva

Vyas

McEachin

et al. 2017

Environ and Mol Mutagen

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Epidemiologic studies and studies in rodents point to potential risks from developmental exposure to BPA on cardiometabolic diseases. Furthermore, it is becoming increasingly evident that the manifestation and severity of adverse outcomes is the result of interaction between developmental insults and the prevailing environment. Consistent with this premise, recent studies in sheep found prenatal BPA treatment prevented the adverse effects of postnatal obesity in inducing hypertension. The gene networks underlying these complex interactions are not known. mRNA-seq of myocardium was performed on four groups of four female sheep to assess the effects of prenatal BPA exposure, postnatal overfeeding and their interaction on gene transcription, pathway perturbations and functional effects. The effects of prenatal exposure to BPA, postnatal overfeeding, and prenatal BPA with postnatal overfeeding all resulted in transcriptional changes (85–141 significant differentially expressed genes). Although the effects of prenatal BPA and postnatal overfeeding did not involve dysregulation of many of the same genes, they affected a remarkably similar set of biological pathways. Furthermore, an additive or synergistic effect was not found in the combined treatment group, but rather prenatal BPA treatment led to a partial reversal of the effects of overfeeding alone. Many genes previously known to be affected by BPA and involved in obesity, hypertension, or heart disease were altered following these treatments, and AP-1, EGR1, and EGFR were key hubs affected by BPA and/or overfeeding.

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Gender-Specific Effects on Gestational Length and Birth Weight by Early Pregnancy BPA Exposure

Cited by 102 publications

References 38 publications

Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis

Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis

Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific Epigenetic Reprogramming as a Potential Mechanism

Developmental programming: Interaction between prenatal BPA and postnatal overfeeding on cardiac tissue gene expression in female sheep

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