Gender-specific Effects of Calcitonin Gene-related Peptide and Substance P on Coronary Blood Flow in an Experimental Model

Ma, Hongyang; Yang, Yan; Cherng, Shen

doi:10.1177/0003319708325450

Cited by 4 publications

(4 citation statements)

References 34 publications

(16 reference statements)

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“…W niniejszym doświadczeniu nie stwierdzono takich włókien ani w warunkach fizjologicznych, ani po podaniu bisfenolu A. Natomiast wcześniejsze badania wykazały stosunkowo dużą ilość CGRP-pozytywnych struktur nerwowych w innych częściach mięśnia sercowego (8,31,35). Ponadto wiadomo, iż CGRP jest ważnym czynnikiem regulującym pracę serca, który między innymi bierze udział w kontroli przepływu krwi przez naczynia wieńcowe oraz wykazuje działanie inotropowo-dodatnie oraz kardioprotekcyjne (11,21). Opisane powyżej różnice sugerują, że unerwienie koniuszka serca wykorzystuje nieco odmienne mechanizmy i substancje aktywne niż struktury nerwowe kontrolujące inne części mięśnia sercowego.…”

Section: Cgrp)unclassified

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Influence of bisfenol A on chemical coding of the nerve fibers of the cardiac apex in the domestic pig

Makowska

Szymańska

Palus

et al. 2017

Medycyna Weterynaryjna

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Section: Cgrp)unclassified

“…Ponadto SP uczestniczy w regulacji przepływu krwi przez naczynia wieńcowe (21,35) oraz pobudza unerwienie cholinergiczne serca, powodując ujemny efekt ino-, batmo-i chronotropowy (11). W warunkach eksperymentalnych SP może oddziaływać stymulująco na wzrost i rozwój kardiomiocytów (9).…”

Section: Cgrp)unclassified

Influence of bisfenol A on chemical coding of the nerve fibers of the cardiac apex in the domestic pig

Makowska

Szymańska

Palus

et al. 2017

Medycyna Weterynaryjna

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“…In particular, SP influences cardiomyocyte activity through the activation of cholinergic innervation and causes bradycardia [55,56]. Moreover, SP regulates the blood flow in vessels located in the heart wall (the character of this impact depends on gender) [57,58] and may stimulate the growth of cardiomyocytes [59] and influence the heart mast cells, stimulating the release of pro-inflammatory factors [60][61][62]. It is also known that SP participates in mechanisms connected with various heart diseases, including viral and parasitic infections, heart ischemia and cardiac fibrosis [54,59].…”

Section: Discussionmentioning

confidence: 99%

Changes Caused by Low Doses of Bisphenol A (BPA) in the Neuro-Chemistry of Nerves Located in the Porcine Heart

Makowska

Gonkowski

2021

Animals

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Bisphenol A (BPA) contained in plastics used in the production of various everyday objects may leach from these items and contaminate food, water and air. As an endocrine disruptor, BPA negatively affects many internal organs and systems. Exposure to BPA also contributes to heart and cardiovascular system dysfunction, but many aspects connected with this activity remain unknown. Therefore, this study aimed to investigate the impact of BPA in a dose of 0.05 mg/kg body weight/day (in many countries such a dose is regarded as a tolerable daily intake–TDI dose of BPA–completely safe for living organisms) on the neurochemical characterization of nerves located in the heart wall using the immunofluorescence technique. The obtained results indicate that BPA (even in such a relatively low dose) increases the number of nerves immunoreactive to neuropeptide Y, substance P and tyrosine hydroxylase (used here as a marker of sympathetic innervation). However, BPA did not change the number of nerves immunoreactive to vesicular acetylcholine transporter (used here as a marker of cholinergic structures). These observations suggest that changes in the heart innervation may be at the root of BPA-induced circulatory disturbances, as well as arrhythmogenic and/or proinflammatory effects of this endocrine disruptor. Moreover, changes in the neurochemical characterization of nerves in the heart wall may be the first sign of exposure to BPA.

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“…As a member of the neurotransmitter tachykinin family, substance P (SP) is widely distributed in the nervous system and peripheral organs and tissues and is involved in pain reaction, immune regulation, inflammatory reaction, and wound healing [2–5]. SP can effectively combat the elevation of blood pressure caused by norepinephrine and angiotensin II (Ang II) and also can lower blood pressure, relax blood vessels, and increase blood flow volume in a short time [6]. Studies have indicated that SP could inhibit the damaging effect of norepinephrine on myocardial cells in acute myocardial ischemia reperfusion, while its effect on myocardial remodeling and its role in the process of fibrosis are not entirely clear [7].…”

Section: Introductionmentioning

confidence: 99%

Substance P Inhibits the Collagen Synthesis of Rat Myocardial Fibroblasts Induced by Ang II

et al. 2016

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BackgroundThe aim of this study was to explore the regulating effects of Substance P (SP) on the collagen synthesis of rat myocardial fibroblasts (CFBs) induced by angiotensin II (Ang II) and its potential mechanism.Material/MethodsThe CFBs of a neonatal SD rat were separately cultured and divided into the control group, Ang II treatment group, and treatment groups with different concentrations of SP, Ang II +; each group was given corresponding treatment respectively.ResultsAng II successfully induced the collagen synthesis of CFBs. Compared with the control group, the phosphorylation levels of TGF-β, erk, and smad2/3 were higher (p<0.05). Different concentrations of SP had an effect on Ang II-induced CFBs, reduced the collagen synthesis of CFBs, and increased the expressions of SP receptors, accompanied by lowering TGF-β protein, erk protein phosphorylation level, and smad2/3 protein phosphorylation level (p<0.05). Moreover, the higher the concentrations of SP, the more obvious of an effect it exerted. Treating the Ang II + SP group with aprepitant reduced the inhibiting effects of SP on collagen synthesis. The expression changes of collagen I and collagen III detected by immunocytochemistry were exactly in accordance with the results of qPCR and Western blotting.ConclusionsSP can inhibit collagen synthesis of CFBs after Ang II inducing which may adjust the downstream signaling pathways associated protein including TGF-β, erk and smad2/3. SP can block the progress of myocardial fibrosis and is dose dependent, which is expected to be a promising target for the treatment of myocardial fibrosis.

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Gender-specific Effects of Calcitonin Gene-related Peptide and Substance P on Coronary Blood Flow in an Experimental Model

Abstract: CGRP plays similar roles as a vasodilator in males and females. SP seems to act as a vasoconstrictor in females.

Cited by 4 publications

References 34 publications

Influence of bisfenol A on chemical coding of the nerve fibers of the cardiac apex in the domestic pig

Influence of bisfenol A on chemical coding of the nerve fibers of the cardiac apex in the domestic pig

Changes Caused by Low Doses of Bisphenol A (BPA) in the Neuro-Chemistry of Nerves Located in the Porcine Heart

Substance P Inhibits the Collagen Synthesis of Rat Myocardial Fibroblasts Induced by Ang II

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