Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ-2 gene on obesity risk and leptin levels in a Tunisian population

Ali, Samir Ben; Yahia, Fatma Ben; Sediri, Yousra; Kallel, Amani; Ftouhi, B.; Feki, Moncef; Elasmi, Monia; Haj-Taieb, Sameh; Souheil, Omar; Sanhagi, Haifa; Slimane, H.; Jemaa, Riadh; Kaabachi, Naziha

doi:10.1016/j.clinbiochem.2009.08.019

Cited by 42 publications

(27 citation statements)

References 41 publications

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“…Nevertheless, a future study in this Mexican-American population including older participants could verify the previously reported associations of PPARG SNPs with obesity. Furthermore, other studies show only association between the PPARG SNP and obesity in a gender-specific manner in Mediterranean (Greek and Tunisian) populations (56,57), which we did not observe in this study. A novel HuGE meta-analysis shows that PPARγ rs1801282 was associated with a reduction in T2D risk; however, they also report a moderate level of heterogeneity, which can lead to variations among ethnic groups (52).…”

Section: Discussioncontrasting

confidence: 99%

Association Study of Candidate Gene Polymorphisms and Obesity in a Young Mexican-American Population from South Texas

Durán-González¹,

Ortiz²,

Gonzales³

et al. 2011

Archives of Medical Research

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Background and Aims Obesity is increasingly a health problem and a risk factor for diabetes in young Mexican-American populations. Genetic association studies in older, mostly non-Hispanic populations have reported that polymorphisms in the candidate genes HSD11B1, CRP, ADIPOQ, PPARG, ANKK1, ABCC8 and SERPINF1 are associated with obesity or diabetes. We analyzed the polymorphisms rs846910, rs1205, rs1501299, rs1801282, rs1800497, rs757110 and rs1136287in these candidate genes, for association with obesity and metabolic traits in a young Mexican-American population from south Texas. Methods Genotyping of the seven common SNPs were performed by allelic discrimination assays in 448 unrelated Mexican Americans (median age = 16 years) from south Texas. χ2 tests and regression analyses using additive models were used for genetic association analyses adjusting for covariates; p values were corrected for multiple testing by permutation analyses. Results rs1800497 (ANKK1) shows association with waist circumference (p = 0.009) and retains the association (p = 0.03) after permutation testing. Analysis of metabolic quantitative traits shows that rs846910 (HSD11B1) was associated with HOMA-IR (p = 0.04) and triglycerides (p = 0.03), and rs1205 (CRP) with HOMA-IR (p = 0.03) and fasting glucose levels (p = 0.007). However, the quantitative traits associations are not maintained after permutation analysis. None of the other SNPs in this study showed associations with obesity or metabolic traits in this young Mexican-American population. Conclusions We report a potential association between rs1800497 (linked to changes in brain dopamine receptor levels) and central obesity in a young Mexican-American population.

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Section: Discussioncontrasting

confidence: 99%

Association Study of Candidate Gene Polymorphisms and Obesity in a Young Mexican-American Population from South Texas

Durán-González¹,

Ortiz²,

Gonzales³

et al. 2011

Archives of Medical Research

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“…However this study did not proceed to body fat measurement or its distribution in order to confirm the polymorphism contribution in obesity. Still, it is supported the hypothesis that Pro 12 Ala polymorphism is a relevant marker in nondiabetic Tunisian man obesity, despite a noneffect on the individuals metabolic characteristics [20]. …”

Section: Resultsmentioning

confidence: 94%

Does Pro¹²Ala Polymorphism Enhance the Physiological Role of PPARγ2?

Pereira

Oliveira

Castro³

et al. 2013

PPAR Research

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Obesity and type 2 diabetes mellitus (T2D) are two major public health problems that have motivated the scientific community to investigate the high contribution of genetic factors to these disorders. The peroxisome proliferator activated by gamma 2 (PPARγ2) plays an important role in the lipid metabolism. Since PPARγ2 is expressed mainly in adipose tissue, a moderate reduction of its activity influences the sensitivity to insulin, diabetes, and other metabolic parameters. The present study aims to contribute to the elucidation of the impact of the Pro12Ala polymorphism associated with T2D and obesity through a meta-analysis study of the literature that included approximately 11500 individuals, from which 3870 were obese and 7625 were diabetic. Statistical evidence supports protective effect in T2D of polymorphism Pro12Ala of PPARγ2 (OR = 0.702 with 95% CI: 0.622; 0.791, P < 0.01). Conversely the same polymorphism Pro12Ala of PPARγ2 seems to favor obesity since 1.196 more chance than nonobese was found (OR = 1.196 with 95% CI: 1.009; 1.417, P < 0.004). Our results suggest that Pro12Ala polymorphism enhances both adipogenic and antidiabetogenic physiological role of PPARγ. Does Pro12Ala polymorphism represent an evolutionary step towards the stabilization of the molecular function of PPARγ transcription factor signaling pathway?

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“…The differences in fat distribution and in physiological and behavioural components between men and women are evident, as well as other precedents of obesity risk factors associated with gender. For instance, the Pro12Ala polymorphism (rs1805192) in PPARG has been found associated with obesity in non-diabetic men [37]. Conversely, the 3111T/C (rs1801260) in CLOCK protect against obesity and overweight only in women [8].…”

Section: Discussionmentioning

confidence: 99%

REV-ERB ALPHA Polymorphism Is Associated with Obesity in the Spanish Obese Male Population

2014

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REV-ERB ALPHA has been shown to link metabolism with circadian rhythms. We aimed to identify new polymorphisms in the promoter of REV-ERB ALPHA and tested whether these polymorphisms could be associated with obesity in the Spanish population. Of the 1197 subjects included in our study, 779 were obese (BMI 34.38±3.1 kg/m2) and 418 lean (BMI 23.27±1.5 kg/m2). In the obese group, 469 of the 779 had type 2 diabetes. Genomic DNA from all the subjects was obtained from peripheral blood cells and the genotyping in the REV-ERB ALPHA promoter was analyzed by High Resolution Melting. We found six polymorphisms in the REV-ERB ALPHA promoter and identified rs939347 as a SNP with the highest frequency in the total population. We did not find any association between rs939347 and type 2 diabetes (p = 0.101), but rs939347 was associated with obesity (p = 0.036) with the genotype AA exhibiting higher frequency in the obese (5.2% in total obese vs 2.4% in lean). This association was found only in men (p = 0.031; 6.5% AA-carriers in obese men vs 1.9% AA-carriers in lean men), with no association found in the female population (p = 0.505; 4.4% AA-carriers in obese women vs 2.7% AA-carriers in lean women). Our results suggest that the REV-ERB ALPHA rs939347 polymorphism could modulate body fat mass in men. The present work supports the role of REV-ERB ALPHA in the development of obesity as well as a potential target for the treatment of obesity.

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Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ-2 gene on obesity risk and leptin levels in a Tunisian population

Cited by 42 publications

References 41 publications

Association Study of Candidate Gene Polymorphisms and Obesity in a Young Mexican-American Population from South Texas

Association Study of Candidate Gene Polymorphisms and Obesity in a Young Mexican-American Population from South Texas

Does Pro¹²Ala Polymorphism Enhance the Physiological Role of PPARγ2?

REV-ERB ALPHA Polymorphism Is Associated with Obesity in the Spanish Obese Male Population

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Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ-2 gene on obesity risk and leptin levels in a Tunisian population

Cited by 42 publications

References 41 publications

Association Study of Candidate Gene Polymorphisms and Obesity in a Young Mexican-American Population from South Texas

Association Study of Candidate Gene Polymorphisms and Obesity in a Young Mexican-American Population from South Texas

Does Pro12Ala Polymorphism Enhance the Physiological Role of PPARγ2?

REV-ERB ALPHA Polymorphism Is Associated with Obesity in the Spanish Obese Male Population

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Does Pro¹²Ala Polymorphism Enhance the Physiological Role of PPARγ2?