Gender specific differences in oxidative stress and inflammatory signaling in healthy term neonates and their mothers

Díaz‐Castro, Javier; Pulido-Morán, Mario; Moreno‐Fernández, Jorge; Kajarabille, Naroa; Paco, Catalina De; Garrido-Sánchez, Maria; Prados, Sonia

doi:10.1038/pr.2016.112

Cited by 34 publications

(30 citation statements)

References 40 publications

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“…For example, miR-4488 expression levels in white blood cells were lower in Behcet patients who experience systemic inflammation and high levels of IL-6, demonstrating a potential role in inflammation [96]. Recent studies have demonstrated differences in IL-6 levels between newborn boys and girls, with lower levels reported in girls [91], consistent with our miRNA findings. Serum expression of miR-663a has been associated with autism spectrum disorder [97], which corroborates with our pathway analysis identifying many neurodevelopmental ontology terms that were strongly enriched among miRNA targets observed in CHAMACOS newborns.…”

Section: Discussionsupporting

confidence: 89%

“…Furthermore, Cordero et al identified 117 miRNAs present in buffy coat samples, which were differentially methylated between men and women [90], some of which overlap with the cord blood miRNAs identified in our study. It is possible that differences in oxidative stress, inflammation, growth and birth outcomes observed between newborn boys and girls [91][92][93] could be controlled, at least in part, by differentially expressed miRNAs. Age is another host factor that can bias epigenetic markers [94,95].…”

Section: Discussionmentioning

confidence: 99%

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miRNAs Differentially Expressed by Next-Generation Sequencing in Cord Blood Buffy Coat Samples of Boys and Girls

et al. 2016

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Aim: Differences in children's development and susceptibility to diseases and exposures have been observed by sex, yet human studies of sex differences in miRNAs are limited. Materials & methods: The genome-wide miRNA expression was characterized by sequencing-based EdgeSeq assay in cord blood buffy coats from 89 newborns, and 564 miRNAs were further analyzed. Results: Differential expression of most miRNAs was higher in boys. Neurodevelopment, RNA metabolism and metabolic ontology terms were enriched among miRNA targets. The majority of upregulated miRNAs (86%) validated by nCounter maintained positive-fold change values; however, only 21% reached statistical significance by false discovery rate. Conclusion: Accounting for host factors like sex may improve the sensitivity of epigenetic analyses for epidemiological studies in early childhood.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

miRNAs Differentially Expressed by Next-Generation Sequencing in Cord Blood Buffy Coat Samples of Boys and Girls

et al. 2016

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“…Male subjects have been found to have higher oxidative stress and lower levels of antioxidant enzymes such as SOD and catalase (Tomas-Zapico et al, 2006). Higher total antioxidant status and lower plasma membrane hydroperoxides were evident in umbilical cord artery of girls compared with boys (Diaz-Castro et al, 2016). Estradiol-induced upregulation of the expression of SOD and GPx (Viña et al, 2005) may protect against oxidative stress in females.…”

Section: Sexual Dimorphism In the Association Between Cr Accumulationmentioning

confidence: 99%

Sexually Dimorphic Impact of Chromium Accumulation on Human Placental Oxidative Stress and Apoptosis

Banu

Stanley

Taylor

et al. 2017

Toxicological Sciences

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Environmental contamination with hexavalent chromium (CrVI) is a growing problem both in the United States and developing countries. Hexavalent chromium is widely used in numerous industries. Environmental exposure to CrVI adversely affects pregnancy outcomes and subsequent health of 2 generations, resulting in higher pregnancy loss, spontaneous abortion and low birth rate. Pregnant women exposed to CrVI through occupational settings experience increased risk of spontaneous abortion, stillbirth, preterm birth, and neonatal death. Children of the CrVI exposed women experience respiratory problems, perinatal jaundice, and increased birth defects. Because placental dysfunction may have a role in such adverse pregnancy outcome, we tested the hypothesis that environmental Cr exposure in pregnant women results in Cr accumulation in the human placenta, which could increase placental oxidative stress by disrupting antioxidant machinery and inducing apoptosis. Studies using frozen, deidentified human term placenta samples indicated that: (1) Cr accumulates in human term placenta tissues and (2) increase in Cr accumulation is positively correlated with oxidative stress and apoptotic markers, and altered antioxidants levels. Interestingly, there was a sexual dimorphism in the correlation between Cr accumulation and oxidative stress, and expression of apoptotic and antioxidant markers. Mechanistic in vitro studies using human trophoblast cells BeWo confirmed the detrimental effects of Cr in altering antioxidant genes. For the first time, this study provides evidence in support of a positive correlation between Cr accumulation in the human placenta and accelerated oxidative stress, with a gender bias toward the male sex.

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“…Gender differences have also been reported in several responses of inflammatory signaling processes, with a tendency towards a more anti-inflammatory environment in female infants. For example, reduced oxidative stress biomarkers and concentrations of myeloperoxidase were found in female preterms [242,243]. In umbilical cord blood, females were shown to have increased CD4+/CD8+ T cell ratios and reduced numbers of NK cells [233].…”

Section: Inflammation and Preterm Sex Differencesmentioning

confidence: 99%

Preterm birth and sustained inflammation: consequences for the neonate

et al. 2020

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Almost half of all preterm births are caused or triggered by an inflammatory process at the feto-maternal interface resulting in preterm labor or rupture of membranes with or without chorioamnionitis (“first inflammatory hit”). Preterm babies have highly vulnerable body surfaces and immature organ systems. They are postnatally confronted with a drastically altered antigen exposure including hospital-specific microbes, artificial devices, drugs, nutritional antigens, and hypoxia or hyperoxia (“second inflammatory hit”). This is of particular importance to extremely preterm infants born before 28 weeks, as they have not experienced important “third-trimester” adaptation processes to tolerate maternal and self-antigens. Instead of a balanced adaptation to extrauterine life, the delicate co-regulation between immune defense mechanisms and immunosuppression (tolerance) to allow microbiome establishment is therefore often disturbed. Hence, preterm infants are predisposed to sepsis but also to several injurious conditions that can contribute to the onset or perpetuation of sustained inflammation (SI). This is a continuing challenge to clinicians involved in the care of preterm infants, as SI is regarded as a crucial mediator for mortality and the development of morbidities in preterm infants. This review will outline the (i) role of inflammation for short-term consequences of preterm birth and (ii) the effect of SI on organ development and long-term outcome.

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Gender specific differences in oxidative stress and inflammatory signaling in healthy term neonates and their mothers

Abstract: An association between gender, oxidative stress, and inflammation signaling exists, leading to a renewed interest in the neonate's sex as a potential risk factor to several alterations.

Cited by 34 publications

References 40 publications

miRNAs Differentially Expressed by Next-Generation Sequencing in Cord Blood Buffy Coat Samples of Boys and Girls

miRNAs Differentially Expressed by Next-Generation Sequencing in Cord Blood Buffy Coat Samples of Boys and Girls

Sexually Dimorphic Impact of Chromium Accumulation on Human Placental Oxidative Stress and Apoptosis

Preterm birth and sustained inflammation: consequences for the neonate

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