Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease

Yunoki, Kei; Naruko, Takahiko; Inaba, Mayumi; Inoue, Takeshi; Nakagawa, Masashi; Sugioka, Kenichi; Ohsawa, Masahiko; Iwasa, Yoko; Komatsu, Ryushi; Itoh, Akira; Haze, Kazuo; Yoshiyama, Minoru; Becker, Anton E.; Ueda, Makiko

doi:10.1016/j.atherosclerosis.2013.08.037

Cited by 32 publications

(17 citation statements)

References 43 publications

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“…Recent evidences indicated that elevated level of myeloperoxidase from the neutrophil could give rise to coronary atherosclerosis [36,37]. Yunoki et al pointed out that plasma myeloperoxidase levels were inversely correlated with HDL-C and serum paraoxonase-1 (PON-1) concentrations and activities [38]. It was supposed that the interaction between myeloperoxidase and HDL-C in the circulation may decrease serum PON-1 levels.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil to high-density lipoprotein ratio has a superior prognostic value in elderly patients with acute myocardial infarction: a comparison study

Huang

Chen

et al. 2020

Lipids Health Dis

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Background: The importance of the lipid-related biomarkers has been implicated in the pathological process and prognosis of acute myocardial infarction (AMI). Our work was conducted to discuss and compare the predictive ability of the neutrophil to high-density lipoprotein cholesterol (HDL-C) ratio (NHR) with other existing prognostic indices, for instance, the monocyte to HDL-C ratio (MHR) and the low-density lipoprotein cholesterol (LDL-C) to HDL-C ratio (LDL-C/HDL-C) in elderly patients with AMI. Methods: Our population was 528 consecutive elderly AMI patients (65-85 years) who were enrolled from Tongji Hospital and grouped according to the cutoff points which were depicted by the receiver operating characteristic (ROC). The Kaplan-Meier curves were plotted with the survival data from the follow-up to investigate the difference between cutoff point-determined groups. Moreover, we assessed the impact of NHR, MHR, LDL-C/HDL-C on the long-term mortality and recurrent myocardial infarction (RMI) with Cox proportional hazard models. Results: Mean duration of follow-up was 673.85 ± 14.32 days (median 679.50 days). According to ROC curve analysis, NHR ≥ 5.74, MHR ≥ 0.67, LDL-C/HDL-C ≥ 3.57 were regarded as high-risk groups. Kaplan-Meier analysis resulted that the high-NHR, high-MHR and high-LDL-C/HDL-C groups presented higher mortality and RMI rate than the corresponding low-risk groups in predicting the long-term clinical outcomes (log-rank test: all P < 0.050). In multivariate analysis, compared with MHR and LDL-C/HDL-C, only NHR was still recognized as a latent predictor for long-term mortality (harzard ratio [HR]: 1.96, 95% confidence interval [CI]: 1.02 to 3.75, P = 0.044) and long-term RMI (HR: 2.23, 95% CI: 1.04 to 4.79, P = 0.040). Furthermore, the positive correlation between NHR and Gensini score (r = 0.15, P < 0.001) indicated that NHR was relevant to the severity of coronary artery to some extent.

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Section: Discussionmentioning

confidence: 99%

Neutrophil to high-density lipoprotein ratio has a superior prognostic value in elderly patients with acute myocardial infarction: a comparison study

Huang

Chen

et al. 2020

Lipids Health Dis

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“…Some recent studies have demonstrated that plasma MPO level has a significant inverse correlation with PON-1 level in patients with stable and unstable angina pectoris, and suggested that the imbalance between pro-oxidants and antioxidants may contribute to the progression of coronary plaque instability [73]. Based on current knowledge, the authors of the current study believe that there may be such a correlation in patients with stable ischemic disease and type 2 diabetes, but this issue requires further studies.…”

Section: Selected Indices Of Hdl and Their Superiority Over Chemical mentioning

confidence: 63%

High-density lipoprotein (HDL) cholesterol – more complicated than we think?

Nessler¹,

Windak²,

Grzybczak³

et al. 2018

Ann Agric Environ Med.

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“…Rios et al (37) speculated that hormonal differences between genders influence lipoprotein oxidation and therefore, the PON1 effect on atherosclerosis. In a recent study, Yunoki et al (38) found that plasma myeloperoxidase levels show a significant inverse correlation with serum PON1 concentrations. We can assume that like myeloperoxidase, there are other mediators that affect PON1 activity and atherosclerotic process in a gender-specific way.…”

Section: Discussionmentioning

confidence: 96%

The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender

Kocakap¹,

Doğru²,

Şimşek³

et al. 2015

Anatol J Cardiol

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Objective:Coronary artery disease (CAD) is a common, complex, and progressive disorder characterized by the accumulation of lipids and fibrous elements in the arteries. It is one of the leading causes of death in industrialized nations. Oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays an important role in the initiation and progression of atherosclerosis. Paraoxonase1 (PON1) is involved in lipid metabolism and is believed to protect LDL oxidation. In our study, we aimed to clarify the relationship between PON1 gene L55M polymorphism and the extent and severity of CAD.Methods:In total, 114 patients (54 males, mean age: 56.7±12.0 years; 60 females, mean age: 55.7±13.2 years) with stable angina or angina equivalent symptoms were enrolled in this prospective study. Cardiological evaluation was performed with electrocardiogram and transthoracic echocardiogram. The presence of hypertension, dyslipidemia, diabetes, and smoking status were ascertained. The patients were grouped according to their Gensini scores and gender. Genetic analysis of the PON1 gene L55M polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism.Results:We determined that the LL genotype was more prevalent in patients with Gensini score higher than or equal to 20 (p=0.026) and that this correlated with severe atherosclerotic coronary artery lesions in both gender groups, reaching a statistical significance in the female subjects (p=0.038).Conclusion:It was thought that the PON1 gene L55M polymorphism plays a significant role in CAD progression, especially in females.

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Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease

Cited by 32 publications

References 43 publications

Neutrophil to high-density lipoprotein ratio has a superior prognostic value in elderly patients with acute myocardial infarction: a comparison study

Neutrophil to high-density lipoprotein ratio has a superior prognostic value in elderly patients with acute myocardial infarction: a comparison study

High-density lipoprotein (HDL) cholesterol – more complicated than we think?

The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender

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