Gender-specific associations between serum isomers of perfluoroalkyl substances and blood pressure among Chinese: Isomers of C8 Health Project in China

Bao, Weizhu; Qian, Zhengmin; Geiger, Sarah Dee; Liu, Echu; Liu, Yimin; Wang, Si Quan; Lawrence, Wayne R.; Yang, Bo; Hu, Li; Zeng, Xiao Wen; Dong, Guang‐Hui

doi:10.1016/j.scitotenv.2017.07.124

Cited by 100 publications

(85 citation statements)

References 57 publications

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“…High blood pressure is one of the most prevalent conditions increasing the risk of cardiovascular events [8]. Several studies in the general population [9][10][11][12][13][14], and just one on 500 highly exposed individuals in China [9] found positive associations between serum PFAS concentrations and hypertension. However, these ndings were not demonstrated in other cross sectional studies [15][16][17][18][19][20], nor in two longitudinal studies on hypertension [21] and one on blood pressure trajectory [22].…”

Section: Introductionmentioning

confidence: 99%

Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults

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Jeddi

Barbieri

et al. 2020

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BackgroundResidents in a large area of North-Eastern Italy were exposed to perfluoroalkyl substances (PFAS) via drinking water. Studies on the association between PFAS and blood pressure levels are limited, and results are inconsistent. Using cross-sectional data from the Regional health surveillance program, we aimed to quantify the associations between PFAS serum concentrations and blood pressure and hypertension prevalence.MethodsThe study comprised 16,224 individuals aged 20-39 years. Pregnant women (n=327), or individuals with missing information on the selected covariates (n=111) were excluded, leaving 15,786 subjects for the analyses. Hypertension was defined as any self-reported diagnosis, use of antihypertensive drugs, or elevated systolic blood pressure (SBP≥140 mmHg)/diastolic blood pressure (DBP≥90 mmHg). Generalized additive models were used to investigate the relation between perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA)) natural log (ln) transformed and by decile, and SBP, DBP, hypertension, adjusted for potential confounders.ResultsBoth SBP and DBP increased significantly with an increase in the ln-transformed serum PFAS concentrations in a monotonic way. The predicted increase in SBP and DBP were 1.54 mmHg (95%CI 0.61-2.47), 1.60 mmHg (95%CI 0.92-2.27) from lowest to highest decile of PFOA. The associations were stronger for SBP in men and for DBP in women. One unit increase in each In-transformed PFAS was positively associated with an increased odd of hypertension in men: PFOA OR=1.06 (1.01-1.11), PFOS OR=1.13 (1.03-1.23), PFHxS OR=1.08 (1.02-1.15), PFNA OR=1.20 (1.02-1.40).ConclusionsOur findings suggest that serum PFAS concentrations were associated with increased systolic and diastolic blood pressure in a large highly exposed young adult population. Although the magnitude of the observed effect was relatively small, if confirmed it would be of public health relevance since even small increases in blood pressure levels at the population level may be associated to a raised risk of adverse outcomes such as cardiovascular disease and target organ damage.

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Section: Introductionmentioning

confidence: 99%

Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults

Pitter

Jeddi

Barbieri

et al. 2020

Preprint

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“…Moreover, reported effect sizes are poorly comparable with each other. The two studies more comparable with the present one in terms of design and population size were conducted on the general US population with exposure levels quite different from ours [9,12]. Although the magnitude of the observed effect was relatively small, if con rmed it would be of public health relevance since it is widely recognized that even small increases in blood pressure levels imply a raised risk of adverse outcomes such as CVD and target organ damage [25].…”

Section: Discussionmentioning

confidence: 55%

“…The observed gender differences were inconsistent between studies [9,11] and requires further investigations. The fact that in our study the association with SBP and hypertension was present mainly in men may re ect the lower serum PFAS levels and lower prevalence of hypertension among women.…”

Section: Discussionmentioning

confidence: 80%

“…As for PFOA, the association was attributable only to branched isomers. Moreover, a strong gender difference was found, with more signi cant associations among females [9].…”

Section: Discussionmentioning

confidence: 92%

“…Other cross-sectional studies with smaller sample size (range n = 48 -187) reported positive [10,13], null [14,16] or negative associations [15]. A study on highly exposed Chinese adults (China C8 Health Project, n = 1612) investigated the association between blood pressure and several PFAS congeners, including linear and branched isomers [9]. Signi cant positive associations emerged for log-transformed PFOS, PFOA, PFNA, PFBA, and PFPeA, but not PFHxS.…”

Section: Discussionmentioning

confidence: 99%

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Perfluoroalkyl Substances Are Associated With Elevated Blood Pressure and Hypertension in Highly Exposed Young Adults

Pitter

Jeddi

Barbieri

et al. 2020

Preprint

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Background Residents in a large area of North-Eastern Italy were exposed to perfluoroalkyl substances (PFAS) via drinking water. Studies on the association between PFAS and blood pressure levels are limited and results inconsistent. Using cross-sectional data from the Regional health surveillance program, we aimed to quantify the associations between PFAS serum concentrations and blood pressure and hypertension prevalence. Methods The study included 16,224 individuals aged 20-39 years. Pregnant women (n=327), or individuals with missing information on the selected covariates (n=111) were excluded, leaving 15,786 subjects. Hypertension was defined as any self-reported diagnosis, use of antihypertensive drugs, or elevated systolic blood pressure (SBP)/diastolic blood pressure (DBP). Generalized additive models were used to investigate the relation between each PFAS (perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA)) ln transformed and by decile, and SBP, DBP, hypertension, adjusted for potential confounders. Results Both SBP and DBP increased significantly with an increase in the ln-transformed serum PFAS concentrations in a monotonic way. The predicted increase in SBP and DBP were 1.54 mmHg (95%CI 0.61-2.47), 1.60 mmHg (95%CI 0.92-2.27) from lowest to highest decile of PFOA. The associations were stronger for SBP in men and DBP in women. One unit increase in each natural log transformed PFAS was positively associated with an increased odd of hypertension in men: PFOA OR=1.06 (1.01-1.11), PFOS OR=1.13 (1.03-1.23), PFHxS OR=1.08 (1.02-1.15), PFNA OR=1.20 (1.02-1.40). Conclusions Our findings suggest that serum PFAS concentrations were associated with moderately increased systolic and diastolic blood pressure in a large highly exposed young adult population. Although the magnitude of the observed effect was relatively small, if confirmed it would be of clinical significance since even small increases in blood pressure levels at population level may be associated to a raised risk of adverse outcomes such as cardiovascular disease and target organ damage.

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Short‐Chain Per/Polyfluoroalkyl Acids (C7 and Below)

Lasee,

Dourson,

Onyema

2024

Patty's Toxicology

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This chapter is about a series of short‐chain per‐ and polyfluoroalkyl substances (PFAS). In the past, PFAS were described as fluorinated fatty acids or sulfonates. The overall structure of PFAS is a carbon chain with fluorine atoms substituting for hydrogen atoms. The resulting chemicals are chemically stable, water and oil resistant, and useful for many industrial applications, such as in the formation of polymers. The most notorious in this group are the fluorinated fatty acids (carboxylates) or sulfonates. In biological systems, these chemicals are generally well‐absorbed by the oral route and resistant to metabolism but also have the unusual property of having drastically different elimination kinetics between mammalian species. The available literature on this group of PFAS (C7 and below) is modest. This chapter will not attempt to review all this literature. Rather, human studies will be emphasized. Since human studies often suggest associations between PFAS exposure and health outcomes, these studies will be followed by definitive experimental animal studies that give insights into the human evidence. Afterward, a summary of attempts to estimate potential human risk by various international agencies will be described. What will become obvious, however, is that the overall uncertainty in the database of some of these chemicals has led to widely divergent risk assessment positions that need to be resolved. Risk management decisions on specific members of this class of chemistries are seen to be premature without such scientific resolution.

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Gender-specific associations between serum isomers of perfluoroalkyl substances and blood pressure among Chinese: Isomers of C8 Health Project in China

Cited by 100 publications

References 57 publications

Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults

Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults

Perfluoroalkyl Substances Are Associated With Elevated Blood Pressure and Hypertension in Highly Exposed Young Adults

Short‐Chain Per/Polyfluoroalkyl Acids (C7 and Below)

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