Gender, smoking, glutathione--transferase variants and bladder cancer incidence: a population-based study

Karagas, Margaret R.; Park, Sunyeong; Warren, Amy J.; Hamilton, Joshua W.; Nelson, Heather H.; Mott, Leila A.; Kelsey, Karl T.

doi:10.1016/j.canlet.2004.10.006

Cited by 64 publications

(42 citation statements)

References 16 publications

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“…[36][37][38][39] Finally, null association was also reported in several other bladder cancer studies with adequate sample size. 31,40,41 Kim et al reported that GSTM1 null genotype was not associated with bladder cancer risk in Korean population. 40 Okkels et al concluded that GSTM1 deletion is not a risk factor for the development of bladder cancer in Denmark population.…”

Section: Discussionmentioning

confidence: 99%

“…41 Additionally, in a study in US Caucasians, no overall association was observed between GSTM1 deletion and bladder cancer risk. 31 In conclusion, this study is the first epidemiologic study to investigate the association between dietary intakes of ITCs and bladder cancer risk in conjunction with the modulation effect of GST and NAT2 genotypes. Our data provide strong evidence that consumption of ITCs from cruciferous vegetable protect against bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

“…However, the frequency of null genotype in Caucasian controls was quite similar between our study (0.50) and several other studies with large sample size. [31][32][33][34][35] For example, the frequency of null genotype was 0.53 in a study with 5,577 Caucasian controls, 32 0.54 in a study with 1,256 US Caucasian controls 33 and 0.51 in a meta-analysis. 28 Thus, genotyping errors should not be an issue for our study.…”

Section: Discussionmentioning

confidence: 99%

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Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk

Zhao¹,

Lin²,

Grossman³

et al. 2007

Intl Journal of Cancer

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TXIsothiocyanates (ITCs) are nonnutrient compounds in cruciferous vegetables with anticarcinogenic properties. ITCs down-regulate cytochrome P-450 biotransformation enzyme levels, activate Phase II detoxifying enzymes and induce apoptosis. On the other hand, ITCs also serve as a substrate for GSTs. Experimental evidences suggest that ITCs have anticarcinogenic effect on bladder cancer. Therefore, we evaluated dietary intake of ITCs, GSTM1, GSTT1 and NAT2 polymorphisms, and bladder cancer risk in a case-control study. There were 697 newly diagnosed bladder cancer cases identified from The University of Texas M. D. Anderson Cancer Center and 708 healthy controls matched to cases by age (65), gender and ethnicity. Participants underwent an in-person interview, in which epidemiologic and food frequency questionnaires were administered to collect demographic and dietary intake data. Median ITC intake per day was statistically significantly lower in cases than in controls (0.23 vs. 0.33, p < 0.001). High ITC intake was associated with 29% decreased risk of bladder cancer [Odds ratio (OR) 5 0.71, 95% confidence interval (CI) 5 0.57, 0.89]. The protective effect was more evident in older individuals (64-years-old), men, ever smokers and heavy smokers in stratified analysis. Compared with NAT2 rapid acetylator, NAT2 slow acetylator had an increased risk of bladder cancer in Caucasians (OR 5 1.31, 95% CI 5 1.02, 1.69). There was no main effect associated with the GSTM1 or GSTT1 genotypes. The protective effect of ITCs against bladder cancer was not modified by GSTM1, GSTT1 or NAT2 genotypes. This is the first epidemiological report that ITCs from cruciferous vegetable consumption protect against bladder cancer. ' 2007 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk

Zhao¹,

Lin²,

Grossman³

et al. 2007

Intl Journal of Cancer

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“…Various studies have shown positive associations between the GSTM1 and GSTT1 null genotypes and increased risk for skin, lung, bladder, and oral cancer (9,(24)(25)(26)(27)(28)(29). Despite several independent studies and subsequent meta-analysis, the reports about the association of HNSCC and the GST variants remain inconclusive (11,30).…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-Transferase Polymorphisms and the Synergy of Alcohol and Tobacco in Oral, Pharyngeal, and Laryngeal Carcinoma

Peters

McClean

Marsit

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Investigations of the ability of polymorphisms in the GSTM1, GSTT1, and GSTP1 genes to alter susceptibility to head and neck squamous cell carcinoma (HNSCC) have examined gene-environment interaction in their detoxification of tobacco-associated carcinogens. Little work has been done to ask if these variant genes also modify the interaction of tobacco and alcohol in the development of HNSCC. To test this hypothesis, we conducted a case-control study, enrolling 692 incident cases of HNSCC and 753 population controls. Information about lifetime tobacco and alcohol use was ascertained through questionnaires, and genotypes for GSTM1, GSTT1, and GSTP1 were determined from constitutional DNA. Genotype frequencies were compared among cases and controls, and the association between genotypes and tobacco use was evaluated on cancer risk through logistic regression. Deletion of GSTM1 was associated with an increased risk for HNSCC [odds ratio (OR), 1.3; 95% confidence interval (95% CI), 1.0-1.6]. GSTT1 deletion was associated with a slight decreased HNSCC risk (OR, 0.8; 95% CI, 0.6-1.0). Among those with GSTM1 present, the OR of cancer for heavy smoking was 2.6 (95% CI, 1.6-4.3) compared with 4.2 for those with the GSTM1 deleted (95% CI, 2.6-6.7). The combination of consuming 10 to 20 alcohol drinks weekly and smoking >45 pack-years was associated with a 13-fold elevated risk (OR, 12.6; 95% CI,2) among the GSTM1 deleted subjects compared with an OR of 3.6 (95% CI, 1.5-8.7) among the GSTM1 present individuals. These data (showing that the GSTM1 deletion affects on the tobacco and alcohol synergy) suggest that the interaction of these carcinogens is, at least in part, driven by alcohol, enhancing the carcinogenic action of tobacco smoke. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2196 -202)

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“…9,10 Si tok rom p450 ve glu tat yon s-trans fe raz gen le ri nin po limor fizm le ri, en do jen me ta bo lit le rin ve kse no biyo tik le rin me ta bo liz ma sın da bi rey ler ara sın da ki fark lı lık tan so rum lu ol ma sı ne de niy le çe şit li kanser araş tır ma la rın da mo le kü ler epi de mi yo lo ji ça lış -ma la rı nın il gi oda ğı ol muş tur. [11][12][13][14][15] Bak te ri yel en fek si yon ve uzun sü re ka lı cı üri-ner ka te ter ta kıl ma sı gi bi çe şit li ne den ler yü zün -den olu şan kro nik inf la mas yon la rın et ki siy le, sal gı la nan nit rit ve nit ro za min le rin çe şit li yo lakla rı et ki le ye rek hüc re pro li fe ras yo nu nu ar tır dı ğı bilin mek te dir. 16,17 Ya pı lan çe şit li ça lış ma lar da, pel vi se uy gu la nan rad yo te ra pi nin me sa ne kan se ri ne ne den ola bi le ceği bil di ril miş tir.…”

Section: Me Sa Ne Kan Se Ri̇ Ni̇n Eti̇ Yo Lo Ji̇ Si̇unclassified

The Role of Molecular Mechanisms in the Development of Bladder Carcinoma: Review

Altayli¹,

Güneş²

2011

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T Kanser türleri içinde önemli bir yer tutan mesane kanseri, Batı ülkelerinde yapılan çalışmalara göre sıklık sıralamasında erkeklerde dördüncü sırayla tüm kanserlerin %5-10'unu, kadınlardaysa sekizinci sıradaki yeriyle % 4'ünü oluşturmaktadır. Mesane kanserinin etiyolojisi, büyük oranda bilinmemekle birlikte, çevresel, demografik ve genetik faktörlerin etkili olduğu düşünülmektedir. Mesane kanserinin gelişiminde rol oynayan çevresel faktörler; sigara, mesleki karsinojenler, şistozomiyazis, kronik sistit, tedavi amaçlı siklofosfamid kullanımı ve pelvik radyoterapidir. Mesane kanserinin gelişiminde rol oynayan demografik faktörler cinsiyet, ırk ve yaştır. Mesane kanserinin gelişiminde çok sayıda onkogenlerin ve tümör süpresör genlerin çeşitli seviyelerdeki mutasyonları önemli rol oynamaktadır. Onkogenler, hücresel seviyede dominant etkiye sahip genlerdir; yani aktive edildiklerinde veya ekspresyon seviyeleri arttığında tek bir mutant allel, bir hücreyi normal fenotipten malign fenotipe dönüştürmeye yetebilir. Mesane kanseriyle ilişkili en iyi bilinen onkogenler; H-ras, erb-B2 ve c-myc'dir. Tümör baskılayıcı genlerse onkogenlerin tersine hücre çoğalmasını inhibe edici özelliktedir. Tümör baskılayıcı genlerin, kanser gelişiminde etkili olabilmesi için her iki allelinin fonksiyonunu yitirmesi gerekir ve dolayısıyla bu genler, kanser gelişimindeki etkileri bakımından resesif özelliktedirler. Kromozom 13q'daki retinoblastoma geni (Rb) ve kromozom 17p'deki p53 geni, en iyi çalışılmış tümör baskılayıcı gendir. Kanserin ilerlemesinde anjiyogenez gelişimi, hücre dışı matriks ve hücre adezyon moleküllerindeki çeşitli anormallikler etkili olmaktadır. Ayrıca mesane kanserinin gelişiminde ve ilerlemesinde, mikrosatellit kararsızlığıyla çeşitli epigenetik faktörlerin de etkili olduğu gösterilmiştir. Mesane kanserinin gelişiminde ve ilerlemesinde rol oynayan karmaşık mekanizmaların anlaşılması için yeni çalışmalara ihtiyaç vardır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Mesane tümörleri; onkojenler; genler, tümör baskılayıcı; karsinojenler; mutasyon; hücre yapışma molekülleri; çok biçimlilik, genetik A AB BS S T TR RA AC CT T Studies performed in Western countries has proven that the bladder carcinoma, which occupies an important place among all cancers, constitutes 5-10% of all male cancers and is the fourth most common cancer in males, while it is eighth most common cancer in females and constitutes 4% of all female cancers. Although etiology of bladder carcinoma is not clearly known, environmental, demographic and genetic factors are thought to be influential. The environmental factors that play role in the development of bladder carcinoma are smoking, occupational carcinogens, schistosomiasis, chronic cystitis, administration of cyclophosphamide for therapeutic purposes and pelvic radiotherapy. Demographic factors that play a role in the development of bladder carcinoma are gender, race and age. The mutations on the different levels of tumor suppressor genes and oncogenes have an important role in...

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Gender, smoking, glutathione--transferase variants and bladder cancer incidence: a population-based study

Cited by 64 publications

References 16 publications

Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk

Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk

Glutathione S-Transferase Polymorphisms and the Synergy of Alcohol and Tobacco in Oral, Pharyngeal, and Laryngeal Carcinoma

The Role of Molecular Mechanisms in the Development of Bladder Carcinoma: Review

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