Gender, Sex and Traumatic Brain Injury: Transformative Science to Optimize Patient Outcomes

Colantonio, Tatyana Mollayeva and Angela

doi:10.12927/hcq.2017.25144

Cited by 20 publications

(12 citation statements)

References 21 publications

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“…Consistent with these findings, the difference in incidence between males and females is no longer apparent at age 65 (Cuthbert et al, 2015; Mushkudiani et al, 2007). Although we are using the term sex (biological and physiological characteristics that distinguish females from males) throughout the review, it should be noted that gender (socially constructed roles, behaviors, relative power, relationships, and other traits that societies ascribe to men and women) can play an important role in human TBI epidemiology (for review, see Mollayeva and Colantonio, 2017).…”

Section: Sex Differences In Tbi: Epidemiologymentioning

confidence: 99%

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

Späni

Braun

Eldik

2018

Frontiers in Neuroendocrinology

129

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Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since men are more likely to experience a TBI because of more frequent participation in activities that increase risk of head injuries. This male bias is also reflected in preclinical research where mostly male animals have been used in basic and translational science. However, with an aging population in which TBI incidence is increasingly sex-independent due to falls, and increasing female participation in high-risk activities, the attention to potential sex differences in TBI responses and outcomes will become more important. These considerations are especially relevant in designing preclinical animal models of TBI that are more predictive of human responses and outcomes. This review characterizes sex differences following TBI with a special emphasis on the contribution of the female sex hormones, progesterone and estrogen, to these differences. This information is potentially important in developing and customizing TBI treatments.

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Section: Sex Differences In Tbi: Epidemiologymentioning

confidence: 99%

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

Späni

Braun

Eldik

2018

Frontiers in Neuroendocrinology

129

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“…In embracing an unbiased comparison across genders (i.e., men and women), recognizing the biological (sex) differences between males and females, and acknowledging the complex and dynamic relationship that exists between sex, gender and other factors (income, education, social environments, health practices, etc.) [ 6 ], great strides have been made. To address the current understanding of mechanisms subserving the influence of sex on epidemiology of concussive sport and work-related injury and injury outcomes (i.e., sex-specific vulnerability), this review is focused on: the sex-specific epidemiology of concussion and sex-/gender-specific clinical manifestations in children and adults with concussion.…”

mentioning

confidence: 99%

Sex & gender considerations in concussion research

2018

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The study of concussion, a common form of mild traumatic brain injury, has received increased notice over the last decade. Recently, more researchers have been addressing the historic paucity of attention over sex and gender influences on recovery outcomes after concussion. This development has led to exciting progress in our understanding of concussion incidence and outcomes. In this review, we will report on new findings from varying studies on sex differences in the epidemiology of concussion and clinical manifestations of mild traumatic brain injury/concussion, further discussing some key issues related to the integration of sex and gender in concussion research in a broad range of contexts, with recommendations to guide future research, along with sex- and gender-sensitive policy considerations.

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“…[9]. Thus, TBI outcome is influenced not only by the brain injury itself but also by the individual's sex-and gender-related experiences which play a major role for the long-term outcome after TBI [10].…”

Section: Introductionmentioning

confidence: 99%

Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span

et al. 2020

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Traumatic brain injury (TBI) is the leading cause of disability in the working population and becomes increasingly prevalent in the elderly. Thus, TBI is a major global health burden. However, age- and sex-related long-term outcome regarding patient’s health-related quality of life (HRQoL) is yet not clarified. In this cross-sectional study, we present age- and sex-related demographics and HRQoL up to 10 years after TBI using the Quality of Life after Brain Injury (QOLIBRI) instrument. The QOLIBRI total score ranges from zero to 100 indicating good (≥ 60), moderate (40–59) or unfavorable (< 40) HRQoL. Two-thirds of the entire chronic TBI cohort (102 males; 33 females) aged 18–85 years reported good HRQoL up to 10 years after TBI. TBI etiology differed between sexes with females suffering more often from traffic- than fall-related TBI (p = 0.01) with increasing prevalence during aging (p = < 0.001). HRQoL (good/moderate/unfavorable) differed between sexes (p < 0.0001) with 17% more females reporting moderate outcome (p = 0.01). Specifically, older females (54–76-years at TBI) were affected, while males constantly reported good HRQoL (p = 0.017). Cognition (p = 0.014), self-perception (p = 0.009), and emotions (p = 0.016) rather than physical problems (p = 0.1) constrained older females’ HRQoL after TBI. Experiencing TBI during aging does not influence HRQoL outcome in males but females suggesting that female brains cope less well with a traumatic injury during aging. Therefore, older females need long-term follow-ups after TBI to detect neuropsychiatric sequels that restrict their quality of life. Further investigations are necessary to uncover the mechanisms of this so far unknown phenomenon.

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Gender, Sex and Traumatic Brain Injury: Transformative Science to Optimize Patient Outcomes

Cited by 20 publications

References 21 publications

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

Sex & gender considerations in concussion research

Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span

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