Gender-Related Outcomes in Trauma

Mostafa, Gamal; Huynh, Toan; Sing, Ronald F.; Miles, William S.; Norton, H. James; Thomason, Michael

doi:10.1097/00005373-200209000-00006

Cited by 133 publications

(97 citation statements)

References 21 publications

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“…25,26 These findings may be related to recent results by Frink et al, 27 who reported that injured females in the ICU had fewer complications related to inflammatory response. It is difficult to compare the results of Frink and colleagues directly, however, because the complications measured in their study were not measured in the present research.…”

Section: Age Sex and Smokingsupporting

confidence: 53%

Systemic Inflammatory Response Syndrome Score and Race As Predictors of Length of Stay in the Intensive Care Unit

NeSmith¹,

Weinrich²,

Andrews³

et al. 2009

American Journal of Critical Care

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Section: Age Sex and Smokingsupporting

confidence: 53%

Systemic Inflammatory Response Syndrome Score and Race As Predictors of Length of Stay in the Intensive Care Unit

NeSmith¹,

Weinrich²,

Andrews³

et al. 2009

American Journal of Critical Care

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“…6,[10][11][12][13][14][15] Less is known about the influence of other demographic variables such as race/ethnicity and socioeconomic status. Critical care research 16,17 (nonspecific to trauma) has shown that African Americans and persons of low socioeconomic status have nearly twice the rates of sepsis, organ dysfunction, and sepsis-related mortality as do whites.…”

mentioning

confidence: 99%

Demographic Differences in Systemic Inflammatory Response Syndrome Score After Trauma

NeSmith

Weinrich

Andrews

et al. 2011

American Journal of Critical Care

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“…We chose a clinical setting (young women undergoing a low stress standardized surgical procedure, i.e., laparoscopy for minor gynecological benign disease) which allowed us to investigate the effects of sevoflurane vs isoflurane, avoiding any interference by other factors which are known to affect hormonal response (age, sex, type and duration of surgery, blood loss, pain, vasoactive drugs, etc.). 8,[26][27][28][29][30] In this setting, we found that catecholamine levels were relatively unaffected by the choice of the main anesthetic drug: surgical stress caused a similar variation of serum catecholamines both in the isoflurane and in the sevoflurane group. Changes in circulating E reflect adrenal medullary activity, whereas changes in NE reflect the activity of the overall sympathetic nervous system.…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane improves the neuroendocrine stress response during laparoscopic pelvic surgery

Marana

Annetta

Meo

et al. 2003

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : Stress response to surgery is modulated by several factors, including magnitude of the injury, type of procedure (e.g., laparoscopy vs laparotomy) and type of anesthesia. Our purpose was to compare intra-and postoperative hormonal changes during isoflurane vs sevoflurane anesthesia, in a clinical model of well defined operative stress (laparoscopic pelvic surgery). M Me et th ho od d: :In this prospective randomized clinical study, 20 women requiring laparoscopic pelvic surgery for benign ovarian cysts received either a standard isoflurane plus fentanyl (Group A) or sevoflurane plus fentanyl anesthesia (Group B). Blood samples were collected preoperatively, 30 min after the beginning of surgery, at the end of surgery after extubation, and two and four hours after the end of surgery. Intra-and postoperative plasma levels of norepinephrine, epinephrine, adrenocorticotropic hormone (ACTH), cortisol, growth hormone (GH) and prolactin (PRL) were measured. R Re es su ul lt ts s: : Catecholamine levels and postoperative pain were similar in both groups. Nonetheless, in comparison to Group A, Group B showed a significant decrease of ACTH, cortisol and GH levels (A vs B at the end of surgery: ACTH 160 ± 45 vs 100 ± 40 pg·mL -1 ; cortisol 45 ± 8 vs 23 ± 7 µg·dL -1 ; GH 3 ± 2 vs 0.8 ± 0.4 ng·mL -1 ; P < 0.001 for all), but enhanced PRL levels (A vs B, at 30 min after the beginning of surgery: 139 ± 54 vs 185 ± 22 ng·mL -1 ; at the end of surgery: 100 ± 27 vs 141 ± 45 ng·mL -1 ; P < 0.001 for both).C Co on nc cl lu us si io on ns s: : In the clinical setting of low stress laparoscopic surgery, the type of volatile anesthetic significantly affected the stress response; the changes associated with sevoflurane suggested a more favourable metabolic and immune response compared to isoflurane. Objectif Méthode : L'étude clinique, prospective et randomisée, a été faite auprès de 20 femmes devant subir une intervention par laparoscopie pelvienne pour des kystes bénins de l'ovaire. Les patientes ont reçu, soit une anesthésie normale à l'isoflurane avec du fentanyl (groupe A), soit au sévoflurane avec du fentanyl (groupe B). Le sang a été prélevé avant l'opération, 30 min après le début, à la fin après l'extubation et, deux et quatre heures après l'opération. Les niveaux plasmatiques peropératoire et postopératoire de noradrénaline, d'adrénaline, d'hormone adrénocorticotrope (ACTH), de cortisol, d'hormone de croissance (GH) et de prolactine (PRL) ont été mesurés.Résultats : Les niveaux de catécholamine et la douleur postopéra-toire ont été similaires dans les deux groupes. Néanmoins, comparé au groupe A, le groupe B a affiché une baisse significative d' ACTH, GH 3 ± 2 vs 0,8 ± 0,

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Gender-Related Outcomes in Trauma

Cited by 133 publications

References 21 publications

Systemic Inflammatory Response Syndrome Score and Race As Predictors of Length of Stay in the Intensive Care Unit

Systemic Inflammatory Response Syndrome Score and Race As Predictors of Length of Stay in the Intensive Care Unit

Demographic Differences in Systemic Inflammatory Response Syndrome Score After Trauma

Sevoflurane improves the neuroendocrine stress response during laparoscopic pelvic surgery

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