Gender-related metabolic outcomes of laparoscopic sleeve gastrectomy in 6-month follow-up

Abstract

Introduction: Laparoscopic sleeve gastrectomy (LSG) is recently a leading method in surgical treatment of morbid obesity. The metabolic outcome of intervention may be a result of many factors such as age, gender, preoperative weight loss and dietary restrictions. Aim: To evaluate gender-related differences in the results of LSG in 6-month follow-up. Material and methods: The study included 101 patients who underwent LSG at the University Clinical Hospital of Bialystok. Patients were divided and analyzed in 2 groups: males (n = 48) and females (n = 53). The primary analysis included the influence of gender on postoperative weight loss calculated using the percentage of excess weight loss (%EWL) and excess BMI loss (%EBMIL). For secondary outcomes the levels of glucose, insulin, glycated hemoglobin, aspartate transaminase, alanine transaminase, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides and C-reactive protein were analyzed. Results: A significant influence of patients' gender was proved for both %EWL (p = 0.026) and %EBMIL (p = 0.001). Females had significantly higher %EWL in 6-month follow-up than males (p = 0.0034). The analysis also showed significantly higher %EBMIL for women at 3 and 6 months observation (p = 0.022 and p < 0.001 respectively). Conclusions: Laparoscopic sleeve gastrectomy is an effective method of obesity treatment especially in terms of postoperative weight loss. Females seem to benefit more from the procedure when analyzing the parameters of body mass reduction. However, further research is needed to provide strong evidence of an association between gender and the results of LSG.

The Effect of Laparoscopic Sleeve Gastrectomy on the Course of Non-Alcoholic Fatty Liver Disease in Morbidly Obese Patients during One Year of Follow Up

“…The previously mentioned research conducted by Bower et al also confirmed an amelioration in liver enzymes profile, including ALT (11.36 [32]. Groth et al also observed an amelioration in the liver enzymes profile in patients undergoing laparoscopic sleeve gastrectomy during 6 months of follow up (AST 22.0 (19.0-28.0) vs. 16.0 (13.0-22.0), p < 0.001, and ALT 27.5 (20.5-41.0) vs. 19.0 (15.0-27.0), p < 0.001) with no statistical differences regarding gender (p = 0.840) [33]. Similar results were observed in our study.…”

Sex dimorphism in the effect and predictors of weight loss after sleeve gastrectomy

“…However, females are significantly more successful on pharmacotherapy for weight loss ( 9 ). Moreover, there is no consensus in clinic in terms of the sex-related differences in the weight-loss effect after SG ( 10 , 11 ). As mentioned above, further research is needed to illustrate the sex differences in the weight-loss effect after SG.…”