Gender-Related Differences in the Relationship Between Densitometric Values of Whole-Body Bone Mineral Content and Lean Body Mass in Humans Between 2 and 87 Years of Age

Ferretti, J.L.; Capozza, Ricardo Francisco; Cointry, Gustavo Roberto; García, S.L; Plotkin, Horacio; Filgueira, M. L. Alvarez; Zanchetta, José R.

doi:10.1016/s8756-3282(98)00046-5

Cited by 185 publications

(130 citation statements)

References 47 publications

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“…Ferretti et al 32 have previously shown that bone mass is linearly associated with muscle mass throughout life. The correlation of bone mineral density and BCM might be on the basis of a genetic association between the development of BCM and bone mineral density.…”

Section: Discussionmentioning

confidence: 97%

Utility of Standard Nutritional Parameters in Detecting Body Cell Mass Depletion in Patients With End-Stage Liver Disease

Figueiredo

2000

Liver Transplantation

139

101

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Protein-calorie malnutrition, best measured by body cell mass (BCM) depletion, has been associated with adverse outcomes in patients with end-stage liver disease. We prospectively measured BCM and multiple standard nutritional parameters in patients with end-stage liver disease to determine which, if any, of the traditionally measured nutritional parameters correlate with BCM. A detailed nutritional assessment, including BCM analysis, subjective global assessment, anthropometry, handgrip dynamometry, laboratory tests, and body composition measured by dual-energy X-ray absorptiometry was performed in 69 sequential patients awaiting liver transplantation. The frequency of abnormalities of specific parameters of nutritional status varied between 19% and 99%. Most of the commonly measured parameters of nutritional status correlated poorly with BCM. Patients with depleted BCM (lowest quartile for sex) had midarm circumference (P < .01), arm-muscle circumference (P < .001), handgrip strength (P < .001), blood urea nitrogen (P < .01), and creatinine (P < .01) values less than those for patients with greater BCM (highest 3 quartiles for sex). In multivariate analysis, arm-muscle circumference and handgrip strength were the best predictors of BCM. The combined criteria of handgrip strength less than 30 kg and arm-muscle circumference less than 23 cm have a sensitivity of 94% and a negative predictive value of 97% in identifying patients with depleted BCM. Although abnormalities of nutritional parameters are highly prevalent among patients with end-stage liver disease, most parameters of nutritional status do not correlate with BCM. In patients with end-stage liver disease, armmuscle circumference and handgrip strength are the most sensitive markers of BCM depletion. (Liver Transpl 2000; 6:575-581.)

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Section: Discussionmentioning

confidence: 97%

Utility of Standard Nutritional Parameters in Detecting Body Cell Mass Depletion in Patients With End-Stage Liver Disease

Figueiredo

2000

Liver Transplantation

139

101

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“…A close association exists between muscle and bone mass (Doyle et al, 1970;Ferretti et al, 1998;Wang et al, 1999). Our data showing reduced FFM and MM in parallel with a disturbed bone turnover in the AN patients compared to the control subjects (Table 1) are in agreement with the findings of Schiessl et al (1998).…”

Section: Discussionmentioning

confidence: 99%

Body mass index and disease duration are predictors of disturbed bone turnover in anorexia nervosa. A case–control study

et al. 2003

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Objective: To characterize the influence of body mass index (BMI), body composition, hormonal factors and disease duration on bone metabolism markers in anorexia nervosa (AN) patients. Design: Case-control study with 51 AN patients and 51 controls matched for age, sex and body height. Assessment of anthropometric and bioimpedance data, and of biochemical serum parameters and of oral contraceptives use. Results: Patients had a lower BMI, lower fat mass, lower fat-free mass and lower muscle mass (MM) compared to the controls (all P values o0.001). Moreover, serum levels of osteocalcin (bone formation marker) were lower while serum C-telopeptide concentrations (CTx; bone resorption marker) and the CTx/osteocalcin ratio (an index reflecting the balance of bone remodeling) were higher in the AN patients compared to the controls (Po0.01-0.001). In addition, patients had enhanced serum calcium and cortisol levels and reduced serum levels of thyroid hormones, insulin, and leptin (P values o0.05-0.001). Mean disease duration was 91713 months. In a multiple regression analysis, BMI (Po0.0001), MM (Po0.005) and duration of the disease (Po0.005) were independent predictors of the CTx/osteocalcin ratio in the AN patients. There was a nonlinear association between BMI and the CTx/osteocalcin ratio of r ¼ À0.72 (Po0.001) in the AN patients, but only a weak relation of r ¼ À0.27 (Po0.05) between these parameters in the control subjects. Use of oral contraceptives had no effect on the CTx/ osteocalcin ratio, neither in AN patients nor in controls. Conclusions: Data indicate an uncoupling of bone formation and bone resorption in AN, which is primarily the result of a low BMI and influenced by the duration of the disease.

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“…Unfortunately we do not have any information on the physical activity of our subjects, the duration of their obesity or any information on hormone levels which undoubtedly in¯uence bone growth and mineral accrual. 30,31 The strengths of our study include the use of large samples of both genders, a wide age range, precise measurements of body composition supplied by DXA and the use of wellaccepted BMI classi®cations of overweight and obesity. Moreover, our predictions were based on regressions from the total samples of each gender, which provide conservative estimates of expected bone mineral content and area in groups of different adiposity.…”

Section: Discussionmentioning

confidence: 99%

Overweight and obese children have low bone mass and area for their weight

et al. 2000

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OBJECTIVES: To determine whether girls and boys categorized from body mass index (BMI) values as overweight or obese for their age have lower bone mineral content (BMC) or lower bone area in relation to total body weight than children of normal adiposity. DESIGN: Cross-sectional study in a university bone research unit. SUBJECTS: Two hundred girls and 136 boys aged 3 ± 19 y recruited from the general population by advertisement. MEASUREMENTS: Total body BMC (g) and bone area (cm 2 ) measured by dual energy X-ray absorptiometry (DXA) in relation to body weight (kg), lean tissue mass (kg) and fat mass (kg) in boys and girls of three different BMI percentile groupings: normal weight (BMI`85th percentile); overweight (85 to 94th BMI percentile); obese ( 95th BMI percentile). RESULTS: Obese children had higher BMC, bone area, and fat mass for chronological age than those of normal body weight (P`0.001). In spite of this the observed values for age-adjusted total body BMC and bone area relative to body weight were each lower than predicted values, in both overweight and obese children (2.5 ± 10.1% less, P`0.05) than in children of lower adiposity. CONCLUSION: In overweight and obese boys and girls there is a mismatch between body weight and bone development during growth: their bone mass and bone area are low for their body weight.

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Gender-Related Differences in the Relationship Between Densitometric Values of Whole-Body Bone Mineral Content and Lean Body Mass in Humans Between 2 and 87 Years of Age

Cited by 185 publications

References 47 publications

Utility of Standard Nutritional Parameters in Detecting Body Cell Mass Depletion in Patients With End-Stage Liver Disease

Utility of Standard Nutritional Parameters in Detecting Body Cell Mass Depletion in Patients With End-Stage Liver Disease

Body mass index and disease duration are predictors of disturbed bone turnover in anorexia nervosa. A case–control study

Overweight and obese children have low bone mass and area for their weight

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