Gender-related differences in the pharmacokinetics of opiates

Djurendic-Brenesel, Maja; Mimica‐Dukić, Neda; Pilija, Vladimir; Tasić, Miloš

doi:10.1016/j.forsciint.2009.10.003

Cited by 24 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, due to known sex differences in response to opioids coupled with sex differences in locomotor activity, both the CPP and locomotor sensitization data were analyzed separately by sex (Cataldo et al, 2010; Djurendic-Brenesel et al, 2010; Wang et al, 2006). Thus, these data were analyzed using two-way ANOVAs with dose and maternal treatment as factors.…”

Section: Methodsmentioning

confidence: 99%

Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring

2016

View full text Add to dashboard Cite

Prescription opiate use and abuse has increased dramatically over the past two decades, including increased use in adolescent populations. Recently, it has been proposed that use during this critical period may affect future offspring even when use is discontinued prior to conception. Here, we utilize a rodent model to examine the effects of adolescent morphine exposure on the reward functioning of the offspring. Female Sprague Dawley rats were administered morphine for 10 days during early adolescence (post-natal day 30–39) using an escalating dosing regimen. Animals then remained drug free until adulthood at which point they were mated with naïve males. Adult offspring (F1 animals) were tested for their response to morphine-induced (0, 1, 2.5, 5, and 10 mg/kg, s.c.) conditioned place preference (CPP) and context-independent morphine-induced sensitization. Naïve littermates were used to examine mu opiate receptor expression in the nucleus accumbens and ventral tegmental area. Results indicate that F1 females whose mothers were exposed to morphine during adolescence (Mor-F1) demonstrate significantly enhanced CPP to the lowest doses of morphine compared with Sal-F1 females. There were no differences in context-independent sensitization between maternal treatment groups. Protein expression analysis showed significantly increased levels of accumbal mu opiate receptor in Mor-F1 offspring and decreased levels in the VTA. Taken together, these findings demonstrate a shift in the dose response curve with regard to the rewarding effects of morphine in Mor-F1 females which may in part be due to altered mu opiate receptor expression in the nucleus accumbens and VTA.

show abstract

Section: Methodsmentioning

confidence: 99%

Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring

2016

View full text Add to dashboard Cite

show abstract

“…8,9 Faster passage of opiates from the blood to the brain in female specimens than in male specimens may partially account GENDER DIFFERENCES IN HEROIN USERS 141 for the gender differences. 10 Furthermore, research also found gender differences in doseresponse curves of opiate reinforcing effects in the place conditioning paradigm: female specimens have strong place preference at high doses (near lethal level), whereas male specimens do not. 11 In human studies, women with heroin dependence reported higher craving 12 and showed more deficits in cognition, such as topographical orientation, than men.…”

Section: Introductionmentioning

confidence: 97%

Gender Differences in Heroin Users Receiving Methadone Maintenance Therapy in Taiwan

Lin

Chang

Wang

et al. 2013

Journal of Addictive Diseases

View full text Add to dashboard Cite

This study examined gender differences in heroin users who first received MMT. Compared with men, female heroin users were younger and more likely to be unemployed, to have family members using illicit substances, to initiate heroin use at a younger age, to begin MMT earlier after starting heroin use, to have methamphetamine use, to initiate methamphetamine use at a younger age, and to report a child-raising burden and a prior history of traumatic experiences. Men were more likely to have use of betel quid, and to initiate alcohol, nicotine and betel quid use at a younger age than women.

show abstract

“…The optimal time period for all experiments was 120 min (Djurendic-Brenesel et al, 2010). Hence, biological samples of experimental animals were taken within this time period, i.e.…”

Section: Resultsmentioning

confidence: 99%

Distribution of opiate alkaloids in brain tissue of experimental animals

Djurendic-Brenesel

Pilija²,

Mimica‐Dukić³

et al. 2012

Interdisciplinary Toxicology

Self Cite

View full text Add to dashboard Cite

The present study examined regional distribution of opiate alkaloids from seized heroin in brain regions of experimental animals in order to select parts with the highest content of opiates. Their analysis should contribute to resolve causes of death due to heroin intake. The tests were performed at different time periods (5, 15, 45 and 120 min) after male and female Wistar rats were treated with seized heroin. Opiate alkaloids (codeine, morphine, acetylcodeine, 6-acetylmorphine and 3,6-diacetylmorphine) were quantitatively determined in brain regions known for their high concentration of µ-opiate receptors: cortex, brainstem, amygdala and basal ganglia, by using gas chromatography–mass spectrometry (GC–MS). The highest content of opiate alkaloids in the brain tissue of female animals was found 15 min and in male animals 45 min after treatment. The highest content of opiates was determined in the basal ganglia of the animals of both genders, indicating that this part of brain tissue presents a reliable sample for identifying and assessing contents of opiates after heroin intake.

show abstract

Gender-related differences in the pharmacokinetics of opiates

Cited by 24 publications

References 30 publications

Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring

Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring

Gender Differences in Heroin Users Receiving Methadone Maintenance Therapy in Taiwan

Distribution of opiate alkaloids in brain tissue of experimental animals

Contact Info

Product

Resources

About