Gender-Related Differences in Celiac Patients at Diagnosis

Lima, Rodrigo Ferreira; Kotze, Lorete Maria da Silva; Kotze, Luiz Roberto; Chrisostomo, Kadija Rahal; Nisihara, Renato

doi:10.1016/j.arcmed.2019.11.007

Cited by 12 publications

(12 citation statements)

References 23 publications

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“…The median ages at diagnosis of CD (6.2 years) and ITP (5.8 years) in our cohort are in accordance with what has been previously reported [ 35 ]. The prevalence of female gender confirms what is observed in the vast majority of studies about CD [ 4 , 7 , 36 ], seeming to overcome the opposite slight prevalence of male gender observed in childhood ITP [ 37 ]. All the potential (n=2) and silent (n=7) cases of CD in our cohort were diagnosed in the groups of “ITP first” and “simultaneous diagnosis”, where CD was diagnosed during the first tests for ITP, raising the question of CD screening at ITP onset.…”

Section: Discussionsupporting

confidence: 84%

Association of Immune Thrombocytopenia and Coeliac Disease in Children (Retrospective Case Control Study)

Guarina¹,

Marinoni²,

Lassandro³

et al. 2021

Tjh

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Objective: The association between celiac disease (CD) and immune thrombocytopenia (ITP) is still uncertain. The aim of this study was to characterize the coexistence of these two diseases in Italian children. Materials and Methods: This is a retrospective multicenter study investigating the occurrence of CD in 28 children with ITP diagnosed from January 1, 2000, to December 31, 2019. Results: The first diagnosis was ITP in 57.1% and CD in 32.1% of patients. In 3 patients (10.7%), the two diagnoses were simultaneous. All the potential and silent cases of CD in our cohort were diagnosed in the groups of “ITP first” and “simultaneous diagnosis”. In all children ITP was mild, and in 2 out of 8 not recovered from ITP at the time of CD diagnosis a normalization of platelet counts (>100,000/μL) occurred 3 and 5 months after starting a gluten-free diet, respectively. Conclusion: We think that screening for CD should be considered in children with ITP regardless of the presence of gastrointestinal symptoms. Furthermore, some patients may recover from ITP after starting a gluten-free diet.

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Section: Discussionsupporting

confidence: 84%

Association of Immune Thrombocytopenia and Coeliac Disease in Children (Retrospective Case Control Study)

Guarina¹,

Marinoni²,

Lassandro³

et al. 2021

Tjh

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“…The symptoms referred by the patients were similar to the reported in Brazilian patients with seropositive CD (11) . Nutritional profile of adults with CD is important, however, in our patients 60% presented normal weight, 10% were above and 30% present overweight.…”

Section: Discussionsupporting

confidence: 82%

Seronegative Celiac Disease in Brazilian Patients: A Series of Cases

Kotze

Utiyama

Kotze

et al. 2021

Arq. Gastroenterol.

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BACKGROUND: Celiac disease (CD) is an autoimmune disease characterized by immune reaction mostly to wheat gluten. The diagnosis is based on clinical, serological and histological findings in patients ingesting gluten. Cases that the clinical profile indicates CD and the autoantibodies are negative bring so a dilemma for the professional, as the risk of missed the diagnosis or a delay at the same. OBJECTIVE: To show the importance of correct diagnosis of cases with seronegative celiac disease (SNCD). METHODS: Ten cases of SNCD Brazilian patients were retrospectively studied (2013 to 2019). Data of clinical complaints, autoantibodies, IgA serum levels, histological findings and HLA-DQ2/DQ-8 were compiled. Dual-X densitometry, delay at diagnosis, previous autoimmune diseases and family history of CD were also checked. RESULTS: All SNCD patients presented clinical symptoms of CD, with confirmed diagnosis by histological findings of the duodenal mucosa and HLA-DQ2 and/or HLA-DQ8 positivity. All patients had normal IgA levels and negative autoantibodies (IgA-anti-transglutaminase and anti-endomysial). Dual-X densitometry detected osteopenia in two women and osteoporosis in two males, all with low levels of vitamin D. Delay diagnostic ranged from 1 to 19 years. Familiar occurrence of CD was reported in 40% of the cases. After one year of gluten-free diet, eight patients refer improve of symptoms, while duodenal biopsies, done in five cases, showed histological improvement. CONCLUSION: Patients who demonstrate the clinical profile of celiac disease with negative serology and normal levels of IgA, especially those who have family members with celiac disease, should be submitted to duodenal biopsies to look for histological findings.

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“…We compared our results to the research conducted in Northern Europe, where CD was found most often in range of tenth and the fortieth year of life [9]. We found out that CD occurs mainly in females, and we also compared our results to the research performed by Lima et al [10], who reported that mostly women suffer from CD. All respondents answered the question of whether they are familiar with the concept of CD and function of gluten in the body.…”

Section: Discussionmentioning

confidence: 73%

The gluten enteropathy in East Slovakia

Harvanová¹,

Duranková²,

Csanády³

2021

pja

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Celiac disease is characterized as an autoimune disorder, and the trigger is gluten delivered into the body in a meal. The main purpose of the study was the issues about gluten enteropaty in East Slovakia, based on special scientific and foreign literature which was avaliable, also there are characteristics about digestion, celiac disease and gluten, critical factors and also premiss beginners of celiac disease. The research, which is discussed at the end of the thesis, was conducted in East Slovakia, namely in the gastroenterologic ambulance in the Humenné town. The above-mentioned research brought us information about the current position of celiac disease between different ages in the Humenné region. Our main aim was to find out whether there is any significant correlation between the age and risk of involvement of celiac disease.

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Gender-Related Differences in Celiac Patients at Diagnosis

Cited by 12 publications

References 23 publications

Association of Immune Thrombocytopenia and Coeliac Disease in Children (Retrospective Case Control Study)

Association of Immune Thrombocytopenia and Coeliac Disease in Children (Retrospective Case Control Study)

Seronegative Celiac Disease in Brazilian Patients: A Series of Cases

The gluten enteropathy in East Slovakia

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