Gender-Related Brain Activations during an Emotional Task: An fMRI Study

Thomas, M.; Gaudeau-Bosma, Christian; Bouaziz, Noomane; Andrianisaina, Palmyre Schenin-King; Benadhira, René; Januel, Dominique; Moulier, Virginie

doi:10.1159/000499977

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…When women make similar failures as men, they will face worse performance evaluations and fewer opportunities to participate in core projects, among other discriminatory outcomes. Furthermore, the neurological evidence suggests that women and men process emotions differently (Thomas et al , 2019; Deng et al , 2016); when women receive negative feedbacks, it tends to weigh more heavily on them, and the effects can be more intense and lasting. The unequal punishments may increase depression and stress in women (Bhui et al , 2016) and decrease work engagement and career aspirations among women (Sia et al , 2015).…”

Section: Discussionmentioning

confidence: 99%

Gender bias in team-building activities in China

Lou

Liu

Chen

et al. 2021

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Purpose The purpose of this study is to explore how gender influences peer assessment in team-building activities in China. Design/methodology/approach A nine-player Werewolf game was adopted to conduct the experiment. Nine abilities were defined to evaluate players’ performances. Before the game, players filled out a self-assessment questionnaire (five-point Likert scale). After the game, players evaluated other game members’ performances using the same questionnaire. Data were analyzed using linear regression. Findings The results showed that gender bias clearly existed in team-building activities, with men more likely to receive better peer assessment than women. In addition, when women presented themselves as actively as men did, they received less favorable evaluations than men, whereas their failures were more likely to be exaggerated. Practical implications This study may help build harmonious teams for gender equality, and we give practical suggestions respectively from the perspective of female employees, their managers, and their companies. Originality/value Given the importance of team-building activities in teamwork, fair evaluations of team-building performances are essential. However, gender influences on peer assessment in team-building activities in China remain unclear. This study adds new and important knowledge to research on gender bias in teams.

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Section: Discussionmentioning

confidence: 99%

Gender bias in team-building activities in China

Lou

Liu

Chen

et al. 2021

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“…Differential activation of frontal cortical areas such as the medial prefrontal cortex (mPFC) and the anterior cingulate cortex (ACC) is evident between men and women depending on the emotional valence of presented stimuli, induced stress levels or prior adverse childhood experiences (Thomas et al, 2019; Javanbakht et al, 2016; Seo et al, 2017; Stevens & Hamann 2012). Accordingly, a dysfunctional activation of those cortical regions and their interaction with the amygdala and the hippocampal formation are observed during emotion regulation in anxiety patients (Mochkovotich et al, 2014; Goossen et al, 2019; Kim & Kim, 2021).…”

Section: Introductionmentioning

confidence: 99%

Sex differences in anxiety and threat avoidance in GAD65 knock-out mice

Ulrich

Pollali

Çalışkan

et al. 2023

Preprint

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Anxiety disorders have been linked to a disbalance of excitation and inhibition in a network of brain structures comprising frontal cortical regions, the amygdala and the hippocampus, among others. While recent imaging studies in humans suggest sex differences in the activation of such anxiety network structures in processing emotional information, the neuronal basis of activation shifts and their relation to anxiety endophenotypes is less well studied. Rodent models with genetically altered ϒ-amino butyric acid (GABA) neurotransmission may provide a targeted approach for addressing such questions, but to date sex effects have rarely been addressed in such models. Using mice with a null mutation of the GABA synthetizing enzyme glutamate decarboxylase 65 (GAD65-/-), we started to compare anxiety-like behavior, discrimination and avoidance learning in male vs. female GAD65-/- mice and their wildtype littermates. Our behavioral test battery revealed increased activity on GAD65-/- mice in the open field and an adaptation of anxiety-like behavior especially in male GAD65-/- mice. Male GAD65-/- mice further displayed a deficit in avoidance learning, while Female GAD65 -/- mice performed well in this task. To gain insights into interneuron function in anxiety and threat perception network structures, fast oscillations (10-45 Hz) were measured in ex vivo slice preparations of the ACC. GAD65-/- mice of both sexes displayed increased gamma power in the ACC that was further accompanied by higher densities of PV-positive interneurons, which are crucial for generating such rhythmic activity. In addition, male GAD65-/- mice had lower numbers of somatostatin-positive interneurons in the basolateral amygdala and dorsal dentate gyrus, two key regions important for anxiety and active avoidance responses. Together, male mice appeared more challenged by GAD65 deficiency in avoidance learning tasks and adapted their anxiety-like response differently, which was associated with an altered interneuron composition and function in an ACC-amygdala-hippocampal network.

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