Gender Predilection in Sporadic Parathyroid Adenomas

Yavropoulou, Maria P; Anastasilakis, Athanasios D.; Panagiotakou, Argyro; Kassi, Evanthia; Makras, Polyzois

doi:10.3390/ijms21082964

Cited by 5 publications

(2 citation statements)

References 69 publications

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“…However, in sporadic cases, women are much more commonly affected. The increase in the incidence of PHPT is observed among women in their sixth decade of life [ 46 ].…”

Section: Primary Hyperparathyroidismmentioning

confidence: 99%

Applications of Metabolomics in Calcium Metabolism Disorders in Humans

Podgórska

Wielogórska

Godzień

et al. 2022

IJMS

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The pathogenesis of the disorders of calcium metabolism is not fully understood. This review discusses the studies in which metabolomics was applied in this area. Indeed, metabolomics could play an essential role in discovering biomarkers and elucidating pathological mechanisms. Despite the limited bibliography, the present review highlights the potential of metabolomics in identifying the biomarkers of some of the most common endocrine disorders, such as primary hyperparathyroidism (PHPT), secondary hyperparathyroidism (SHPT), calcium deficiency, osteoporosis and vitamin D supplementation. Metabolites related to above-mentioned diseorders were grouped into specific classes and mapped into metabolic pathways. Furthermore, disturbed metabolic pathways can open up new directions for the in-depth exploration of the basic mechanisms of these diseases at the molecular level.

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“…However, in sporadic cases, women are much more commonly affected. The increase in the incidence of PHPT is observed among women in their sixth decade of life [ 46 ].…”

Section: Primary Hyperparathyroidismmentioning

confidence: 99%

Applications of Metabolomics in Calcium Metabolism Disorders in Humans

Podgórska

Wielogórska

Godzień

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Unfortunately, little is known about the sex differences in PHPT incidence and clinical presentation. While estrogens might be potentially associated with PTH secretion, no direct evidence has been discovered ( 9 ). The role of sex in PHPT pathogenesis and outcome remains unclear, and therefore, personalized and sex-specific treatment of PHPT is still impossible to be implemented.…”

Section: Introductionmentioning

confidence: 99%

Single-cell RNA sequencing reveals the role of cell heterogeneity in the sex difference in primary hyperparathyroidism

et al. 2023

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ObjectiveTo explore the difference in parathyroid tissue-derived cells between male and female PHPT patients.MethodsResected parathyroid tissues were collected from PHPT patients of both sexes. Single cells were isolated and sequenced for RNA expression profiles. The cell sequencing data were annotated by cell type, followed by population analysis, functional analysis, pathway analysis, cell communication analysis, differential gene expression analysis, and pseudotime trajectory analysis. The subcluster analyses were also performed in the parathyroid cells.ResultsNo substantial difference in the cell population, function, or communication is found between the two sexes. The interferon-a response, oxidative phosphorylation, and reactive oxygen species pathways are up-regulated in females than in male patients, mainly contributed by fibroblast cells, endothelial cells, parathyroid cells, and myeloid cells, which also have significantly more up-regulated pathways and cellular interactions than the other three cell types. The subcluster analysis of parathyroid cells identified five subpopulations: SPARCL1-OC and ISG15-OC are predominant in females, while more S100A13-PCC and PTHLH-OC are found in males. The cellular functions are also elevated in females compared with males. Cells from female patients show a higher expression level of parathyroid hormone (PTH) but a lower expression level of parathyroid hormone-like hormone (PTHLH). The cell pseudotime trajectory and pathway analyses show that the oxyphil cells may be more mature and functionally active than the chief cells in both sexes.ConclusionThese findings suggest that the sex difference in PHPT may be caused by the differentially expressed genes and activated pathways in different cell types in the parathyroid tissue. The heterogeneity of parathyroid cell subpopulations, especially in oxyphil cells, may be associated with the sex differences in PHPT pathogenesis.

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Primary Hyperparathyroidism in the Common Orthopaedic Practice

Sferopoulos¹

2021

TOORTHJ

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An extensive review of the publications on primary hyperparathyroidism (pHPT) is presented in this report. It has strongly been emphasized in the literature that patients with pHPT may present either with the classical symptomatology or with asymptomatic disease, emerged due to biochemical screening. The clinical and epidemiological presentation of pHPT in western countries has changed profoundly during the past few decades, and bone disease is nowadays a distinct rarity. The introduction of serum calcium screening for osteoporosis and the technological advances in the laboratory assessment of parathyroid hormone have played important roles in early diagnosis. Subsequently, the disease is increasingly being detected as asymptomatic hypercalcaemia without guiding signs or symptoms. A third type of disease, the normocalcaemic variant, has been recently described in the literature. However, the potential diagnosis of pHPT should always be on the orthopaedics’ list of differential diagnoses in female or elderly patients with vertebral fractures and nephrolithiasis, either symptomatic or asymptomatic, as well as when solitary or multiple osteolytic lesions are encountered on the radiographs. Additionally, a middle aged woman with parathyroid adenoma and subsequent brown tumors detected on the pelvic radiographs is reported. Her initial laboratory findings indicated a minimal increase of the serum calcium, a mild increase of the erythrocyte sedimentation rate, and a significant increase in total serum alkaline phosphatase. Finally, the detection of elevated parathyroid hormone levels indicated the diagnosis of pHPT and necessitated imaging studies of the parathyroid glands, which indicated a parathyroid adenoma. Following successful excision of the parathyroid adenoma, the patient suffered from the hungry bone syndrome. After a follow-up of 20 years, the patient had normal calcium, vitamin D, and parathyroid hormone serum levels, while a pelvic radiograph indicated no significant changes in the appearance of the brown tumors.

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Gender Predilection in Sporadic Parathyroid Adenomas

Cited by 5 publications

References 69 publications

Applications of Metabolomics in Calcium Metabolism Disorders in Humans

Applications of Metabolomics in Calcium Metabolism Disorders in Humans

Single-cell RNA sequencing reveals the role of cell heterogeneity in the sex difference in primary hyperparathyroidism

Primary Hyperparathyroidism in the Common Orthopaedic Practice

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