Gender Moderates Chronic Nicotine Cigarette Effects on Verbal Memory in Young Adults

Kangiser, Megan M.; Lochner, Angelina; Thomas, Alicia M.; Medina, Krista Lisdahl

doi:10.1080/10826084.2019.1613432

Cited by 3 publications

(4 citation statements)

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“…This investigation is the first known study of e-cigarette use that objectively measured neurocognitive performance, and no differences in cognition by nicotine group status were observed. Cognitive differences in adolescent and young adult NTP users have been noted previously [13,14,53], though not always [53,54]. E-cigarettes specifically have been linked to poorer self-reported neurocognition [20,21], though subjective concerns may not relate to true performance deficits.…”

Section: Discussionmentioning

confidence: 90%

Young Adult E-Cigarette and Combustible Tobacco Users Attitudes, Substance Use Behaviors, Mental Health, and Neurocognitive Performance

et al. 2022

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Nicotine and tobacco product (NTP) use has escalated, largely due to the advent of e-cigarettes. The NTP administration method (i.e., combustible cigarette, e-cigarette) may be an important differentiator. We assessed young adult substance use history, nicotine attitudes, mental health, and neurocognition by the NTP use method. Emerging adults (16–22 year olds) were divided into combustible NTP users (Combustible+ = 79, had used any combustible NTP in the last 6 months), non-combustible users (E-Cig = 43, had used non-combustible NTP, in the past 6 months), and NTP Naïve (n = 79; had not used NTP in the past 6 months) based on past 6-month NTP use patterns. Participants completed self-report and objective neurocognition measures. Analysis of covariance assessed mental health and neurocognition by group, controlling for confounds and correcting for multiple comparisons. Nicotine groups reported more favorable attitudes toward combustible cigarette and e-cigarette use, with taste as the primary reason for e-cigarette use. Combustible+ reported more nicotine dependence and craving. Substance use differed by group, with Combustible+ using the most NTP, alcohol, and cannabis. Nicotine groups reported higher depression and stress symptoms; male Combustible+ reported higher depression symptoms than other same-gender groups. Groups did not differ on neurocognition, though cannabis use was associated with inaccurate emotional Stroop responses. Overall, research suggests that young adult combustible users are likely qualitatively different from non-combustible users. Understanding the unique characteristics related to NTP product use will help guide intervention and prevention development.

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Section: Discussionmentioning

confidence: 90%

Young Adult E-Cigarette and Combustible Tobacco Users Attitudes, Substance Use Behaviors, Mental Health, and Neurocognitive Performance

et al. 2022

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“…We found one relation between NTP measures and verbal memory, as a higher cotinine concentration was associated with poorer verbal memory. This is in contrast to other cross-sectional studies of young adult nicotine users (Kangiser et al, 2019). We allowed smoking up to an hour before testing and, therefore, do not believe this to be due to withdrawal effects (Jacobsen et al, 2005).…”

Section: Discussionmentioning

confidence: 95%

“…This is consistent with cannabis (Jacobus et al, 2015;Solowij et al, 2011) and alcohol (Spear, 2018) literature suggesting memory deficits in regular adolescent and young adult users. Preliminary evidence also suggests greater frequency of nicotine use is associated with cognitive deficits (Vajravelu et al, 2015), and sex may moderate the influence of nicotine on memory (Kangiser et al, 2019). While nicotine may acutely improve cognition (Campos, Serebrisky, & Castaldelli-Maia, 2016), and attenuate cannabis-related cognitive decline (Schuster et al, 2015), more recent and chronic use (such as would be measured in cotinine) may be associated with unique cognitive decline in consolidation and retention.…”

Section: Discussionmentioning

confidence: 99%

“…Acute nicotine smoking was shown to increase verbal memory performance in young adults (Potter, Hammond, Tuffnell, Walker, & Di Forti, 2018) with decrements in performance occurring during withdrawal (Jacobsen et al, 2005). A recent study suggested chronic nicotine use during young adulthood was positively associated with verbal memory performance in females, but not males (Kangiser, Lochner, Thomas, & Lisdahl, 2019), and some find poorer verbal recall associated with greater intensity (cigarettes per day and duration) of nicotine intake (Vajravelu, Gnanadurai, Krishnan, & Ayyavoo, 2015). Adding to the complexity, some also found that nicotine may mask memory deficits in young adult cannabis users (Hindocha, Freeman, Xia, Shaban, & Curran, 2017;Schuster, Crane, Mermelstein, & Gonzalez, 2015), suggesting interaction between the two substances wherein memory deficits may be most evident among low (or no) levels of nicotine use.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary Evidence for Cannabis and Nicotine Urinary Metabolites as Predictors of Verbal Memory Performance and Learning Among Young Adults

Wade

Baca

Courtney

et al. 2021

J Int Neuropsychol Soc

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Objective:Verbal memory deficits are linked to cannabis use. However, self-reported episodic use does not allow for assessment of variance from other factors (e.g., cannabis potency, route of consumption) that are important for assessing brain-behavior relationships. Further, co-occurring nicotine use may moderate the influence of cannabis on cognition. Here we utilized objective urinary measurements to assess the relationship between metabolites of cannabis, 11-nor-9-carboxy-∆9-tetrahydrocannabinol (THCCOOH), and nicotine (cotinine) on verbal memory in young adults.Method:Adolescents and young adults (n = 103) aged 16–22 completed urinary drug testing and verbal memory assessment (RAVLT). Linear regressions examined the influence of THCCOOH and cotinine quantitative concentrations, and their interaction, on RAVLT scores, controlling for demographics and alcohol. Cannabis intake frequency was also investigated. Secondary analyses examined whether past month or recency of use related to performance, while controlling for THCCOOH and cotinine concentrations.Results:THCCOOH concentration related to both poorer total learning and long delay recall. Cotinine concentration related to poorer short delay recall. Higher frequency cannabis use status was associated with poorer initial learning and poorer short delay. When comparing to self-report, THCCOOH and cotinine concentrations were negatively related to learning and memory performance, while self-report was not.Conclusions:Results confirm the negative relationship between verbal memory and cannabis use, extending findings with objective urinary THCCOOH, and cotinine concentration measurements. No moderating relationship with nicotine was found, though cotinine concentration independently associated with negative short delay performance. Findings support the use of both urinary and self-report metrics as complementary methods in substance use research.

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Nicotine Effects on White Matter Microstructure in Young Adults

Kangiser

Thomas

Kaiver

et al. 2019

Archives of Clinical Neuropsychology

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Objective Nicotine use is widely prevalent among youth, and is associated with white matter microstructural changes as measured by diffusion tensor imaging (DTI). In adults, nicotine use is generally associated with lower fractional anisotropy (FA), but in adolescents/young adults (≤30 years), microstructure appears healthier, indicated by higher FA. This cross-sectional study examined associations between nicotine use and white matter microstructure using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in young adults. Methods Fifty-three participants (18 nicotine users [10 female]/35 controls [17 female]) ages 18–25 underwent MRI scan, neuropsychological battery, toxicology screening, and drug use interview. Nicotine group associations with FA and MD were examined in various white matter tracts. In significant tracts, AD and RD were measured. Exploratory correlations were conducted between significant tracts and verbal memory and sustained attention/working memory performance. Results Nicotine users exhibited significantly lower FA than controls in the left anterior thalamic radiation, left inferior longitudinal fasciculus, left superior longitudinal fasciculus—temporal, and left uncinate fasciculus. In these tracts, AD and RD did not differ, nor did MD differ in any tract. White matter quality was positively correlated with sustained attention/working memory performance. Conclusions Cigarette smoking may disrupt white matter microstructure. These results are consistent with adult studies, but inconsistent with adolescent/young adult studies, likely due to methodological and sample age differences. Further studies should examine longitudinal effects of nicotine use on white matter microstructure in a larger sample.

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Gender Moderates Chronic Nicotine Cigarette Effects on Verbal Memory in Young Adults

Cited by 3 publications

References 69 publications

Young Adult E-Cigarette and Combustible Tobacco Users Attitudes, Substance Use Behaviors, Mental Health, and Neurocognitive Performance

Young Adult E-Cigarette and Combustible Tobacco Users Attitudes, Substance Use Behaviors, Mental Health, and Neurocognitive Performance

Preliminary Evidence for Cannabis and Nicotine Urinary Metabolites as Predictors of Verbal Memory Performance and Learning Among Young Adults

Nicotine Effects on White Matter Microstructure in Young Adults

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