Gender matters in schizophrenia-spectrum disorders: Results from a healthcare users epidemiological study in Malaga, Spain

Petkari, Eleni; Mayoral, Fermín; Moreno-Küstner, Berta

doi:10.1016/j.comppsych.2016.09.012

Cited by 14 publications

(10 citation statements)

References 45 publications

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“…This result is consistent with literature, suggesting sex differences in schizophrenia spectrum disorders (e.g. [82,83]). For example, men tend to suffer earlier onset of schizophrenia, and distinct neurobiological networks might underpin positive symptoms in men compared to women [11,84].…”

Section: )supporting

confidence: 93%

Reduction in lower-alpha power during Ganzfeld flicker stimulation is associated with the production of imagery and trait positive schizotypy

et al. 2018

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Light-flicker Ganzfeld (LFG) induces a lower to upper-alpha frequency shift. However, it is unclear how this neurophysiological response might relate to LFG-induced pseudohallucinatory phenomena. It is also unknown whether emotional states (e.g., fear) or traits associated with risk for psychosis (e.g., proneness to perceptual anomalies, ability to produce vivid mental imagery) affect such neurophysiological and/or perceptual responses to LFG.The present study investigated alpha sub-bands during LFG across several flicker frequencies, in relation to individual differences in propensity for Ganzfeld-induced imagery (GI), positive schizotypy and trait mental imagery, and in relation to manipulations of affective state. Given previously reported sex differences in risk for psychosis and response to Ganzfeld, the effect of sex on GI was also studied. Forty-six healthy adults (16 men) completed psychometric measures of trait mental imagery and positive schizotypy before undergoing three LFG (20 minutes each) conditions. In each condition, participants wore white-out goggles and listened to either mood-inducing soundscapes (fear, serenity) or pink noise (control) through headphones. Greatest propensity for GI arose between 12-16 Hz flicker, with a peak at 16 Hz flicker. Occipital lower-alpha was reduced for lower flicker frequencies (12-16 Hz) and was inversely associated with GI. Upper-alpha power was not significantly related to GI or to other measures. Fear-induction was associated with reduction in alpha power, but did not significantly affect GI. Men reported more GI than women. Findings support a role for cortical destabilisation, as reflected in reduced lower-alpha, in perceptual anomalies; and, by extension, LFG as an experimental model of liability to psychosis.

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Section: )supporting

confidence: 93%

Reduction in lower-alpha power during Ganzfeld flicker stimulation is associated with the production of imagery and trait positive schizotypy

et al. 2018

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“…A lower frequency of being partnered/married has been reported in males in most (1,5,15,101,102) although not all (55,103) studies. It has been hypothesized that this is related to the preponderance of negative symptoms in males' clinical picture or to their earlier illness onset, which may both have stood as barriers to develop intimate relationships.…”

Section: Socio-demographic and Clinical Indices Of Outcomementioning

confidence: 84%

Gender Differences in Clinical and Psychosocial Features Among Persons With Schizophrenia: A Mini Review

et al. 2021

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An extensive literature regarding gender differences relevant to several aspects of schizophrenia is nowadays available. It includes some robust findings as well as some inconsistencies. In the present review, we summarize the literature on gender differences in schizophrenia relevant to clinical and social outcome as well as their determinants, focusing on clinical variables, while gender differences on biological factors which may have an impact on the outcome of the disorder were not included herewith. Consistent findings include, in male with respect to female patients, an earlier age of illness onset limited to early- and middle-onset schizophrenia, a worse premorbid functioning, a greater severity of negative symptoms, a lower severity of affective symptoms and a higher rate of comorbid alcohol/substance abuse. Discrepant findings have been reported on gender differences in positive symptoms and in social and non-social cognition, as well as in functional outcome and rates of recovery. In fact, despite the overall finding of a more severe clinical picture in males, this does not seem to translate into a worse outcome. From the recent literature emerges that, although some findings on gender differences in schizophrenia are consistent, there are still aspects of clinical and functional outcome which need clarification by means of further studies taking into account several methodological issues.

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“…Finally, Petkary et al (2016) showed that the role of gender in schizophrenia has become a very important matter for designing effective psychosocial services to focus on patient needs.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of the incidence of psychotic disorders: the distribution of rates and the influence of gender, urbanicity, immigration and socio-economic level

2018

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Gender matters in schizophrenia-spectrum disorders: Results from a healthcare users epidemiological study in Malaga, Spain

Cited by 14 publications

References 45 publications

Reduction in lower-alpha power during Ganzfeld flicker stimulation is associated with the production of imagery and trait positive schizotypy

Reduction in lower-alpha power during Ganzfeld flicker stimulation is associated with the production of imagery and trait positive schizotypy

Gender Differences in Clinical and Psychosocial Features Among Persons With Schizophrenia: A Mini Review

A systematic review and meta-analysis of the incidence of psychotic disorders: the distribution of rates and the influence of gender, urbanicity, immigration and socio-economic level

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