Gender Influence on the Performance of Chest Compressions in Simulated Hypogravity and Microgravity

Kordi, Mehdi; Kluge, Nicholas; Kloeckner, M.; Russomano, Thaís

doi:10.3357/asem.3171.2012

Cited by 10 publications

(7 citation statements)

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“…Other studies performed on humans, also under suspension, have focused on the performance of chest compressions under partial and microgravity. In both reports, the mean frequency of external chest compression did not result in a pattern relative to the level of gravity exposure in either male or female subjects (Dalmarco et al, ; Kordi et al, ). On another area of research, investigators studied the human perception of verticality during a recent parabolic flight campaign of partial gravity.…”

Section: Discussionmentioning

confidence: 92%

Cell cultivation under different gravitational loads using a novel random positioning incubator

Damm

Walther

Wüest

et al. 2014

Biotech & Bioengineering

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Important in biotechnology is the establishment of cell culture methods that reflect the in vivo situation accurately. One approach for reaching this goal is through 3D cell cultivation that mimics tissue or organ structures and functions. We present here a newly designed and constructed random positioning incubator (RPI) that enables 3D cell culture in simulated microgravity (0 g). In addition to growing cells in a weightlessness-like environment, our RPI enables long-duration cell cultivation under various gravitational loads, ranging from close to 0 g to almost 1 g. This allows the study of the mechanotransductional process of cells involved in the conversion of physical forces to an appropriate biochemical response. Gravity is a type of physical force with profound developmental implications in cellular systems as it modulates the resulting signaling cascades as a consequence of mechanical loading. The experiments presented here were conducted on mouse skeletal myoblasts and human lymphocytes, two types of cells that have been shown in the past to be particularly sensitive to changes in gravity. Our novel RPI will expand the horizon at which mechanobiological experiments are conducted. The scientific data gathered may not only improve the sustainment of human life in space, but also lead to the design of alternative countermeasures against diseases related to impaired mechanosensation and downstream signaling processes on earth.

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Section: Discussionmentioning

confidence: 92%

Cell cultivation under different gravitational loads using a novel random positioning incubator

Damm

Walther

Wüest

et al. 2014

Biotech & Bioengineering

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“…CPR using the RBH was seen to initially provide an adequate depth and rate of chest compression, in accordance with the most recent guidelines. Nonetheless, as early as the second cycle of chest compressions, rescuers rapidly tired-resulting in a decline in the depth of chest compressions and overall drop in the quality of CPR [44,45]. Logistically, this method also presents a problem in ventilating as the rescuer is positioned to the rear of the patient.…”

Section: Reverse Bear Hug Cpr Methodsmentioning

confidence: 99%

“…These studies also assessed the physiological cost of performing these methods, compared to terrestrial CPR. Using more objective measures, such as oxygen uptake (VO 2 ), these studies demonstrated that all three methods had a greater VO 2 than terrestrial CPR, with the HS being the least aerobically demanding and the RBH the most demanding [44,48].…”

Section: Resuscitation Aspects 132mentioning

confidence: 99%

“…When thinking about the technique of terrestrial CPR, with the rescuer accelerating their chest and upper body to generate a force to compress the patient's chest, it is obvious that this cannot work in microgravity without significant aids. To this end, several microgravity CPR techniques have been developed and tested in parabolic flights [4,42,43] and during ground simulations, such as when using a body suspension device system, to test their efficacy [5,44,45].…”

Section: Extraterrestrial Cpr Simulationsmentioning

confidence: 99%

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Extraterrestrial CPR and Its Applications in Terrestrial Medicine

Russomano¹,

Rehnberg²

2017

Resuscitation Aspects

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Cardiopulmonary resuscitation (CPR) is a well-established part of basic life support (BLS), saving countless lives since its first development in the 1960s. Recently, work has been undertaken to develop methods of basic and advanced life support (ALS) in microgravity and hypogravity. Although the likelihood of a dangerous cardiac event occurring during space mission is rare, the possibility exists. The selection process for space missions nowadays considers individuals at ages and with health standards that would have precluded their selection in the past. The advent of space tourism may even enhance this possibility. This chapter presents a synthesis of the results obtained in studies conducted at the MicroG-PUCRS, Brazil, examining extraterrestrial CPR during ground-based microgravity and hypogravity simulations and during parabolic flights and sustained microgravity. It outlines the extraterrestrial BLS guidelines for both low-orbit and deepspace missions. The former are based on a combination of factors, unique for the environment of space. In a setting like this, increased physiological stress due to gravitational adaptation and the isolated nature of the environmental demands can affect the outcome of resuscitation procedure.

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“…Weight is not a factor in microgravity CPR, as crewmembers cannot utilize their weight to perform ECCs, but muscle mass has been suggested to be 17 . This was suggested in a study done by Kordi et al (2012) that concluded that both genders can perform effective ECCs during simulated hypogravity, however woman do not perform ECCs as effectively in microgravity conditions, particularly using the ER method 17 . Again, future work is needed in this area to fully evaluate factors that affect females performing CPR in microgravity in order to develop countermeasures.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

A new method for the performance of external chest compressions during hypogravity simulation

Mackaill

Sponchiado

Leite

et al. 2018

Life Sciences in Space Research

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Gender Influence on the Performance of Chest Compressions in Simulated Hypogravity and Microgravity

Abstract: The results suggest both genders can perform effective ECCs during simulated hypogravity. Women, however, cannot perform effective ECCs during microgravity simulation. These findings suggest that there is a gender difference when performing the Evetts-Russomano method.

Cited by 10 publications

References 0 publications

Cell cultivation under different gravitational loads using a novel random positioning incubator

Cell cultivation under different gravitational loads using a novel random positioning incubator

Extraterrestrial CPR and Its Applications in Terrestrial Medicine

A new method for the performance of external chest compressions during hypogravity simulation

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