Gender influence on the bipolar disorder inpatient length of stay in Sweden, 2005–2014: A register-based study

Ragazan, Dragos C.; Eberhard, Jonas; Ösby, Urban; Berge, Jonas

doi:10.1016/j.jad.2019.05.052

Cited by 10 publications

(8 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings are then in line with another RCT metaanalysis which found no significant sex-related differences for aripiprazole in preventing manic or depressive relapses (54). Aripiprazole has been suggested as an adjunct for the management of comorbid borderline personality disorder (36); a characteristic seen more often among females (27,30). It is plausible that aripiprazole was used for similar indications among our cohort (i.e., other comorbidities), though this was not assessed in the present study and merits further investigation.…”

Section: Discussionsupporting

confidence: 77%

“…Prescription patterns could also vary but this too is disputed. For example, Karanti et al (29) found Swedish males to be significantly more likely to receive outpatient treatment with lithium, and females with lamotrigine; whereas we previously found no sex-specific differences in treatment among Swedes within the 3-months prior to their hospitalizations (30).…”

Section: Introductioncontrasting

confidence: 70%

See 1 more Smart Citation

Sex-Specific Associations Between Bipolar Disorder Pharmacological Maintenance Therapies and Inpatient Rehospitalizations: A 9-Year Swedish National Registry Study

2020

Self Cite

View full text Add to dashboard Cite

Background: Long-term pharmacological maintenance therapy is often essential among people with bipolar disorder to reduce the need for inpatient care. Sex-specific responses to maintenance therapies are expected but remain largely unknown. Here, we examined for sex-specific associations between common maintenance therapies for bipolar disorder with inpatient rehospitalizations following patients' index discharges during 2006–2014. Methods: Population-based data on maintenance therapies and rehospitalizations were extracted from Swedish national registries. We adopted the within-individual design to compare the time on- vs. off- maintenance therapy for males and females, respectively. Extended stratified Cox proportional hazards regression models were employed to quantify the rate of rehospitalization as a function of common maintenance drugs and other important time-varying control variables. Results: Our primary analysis included 22,681 bipolar disorder rehospitalizations by 6,400 males and 9,588 (60.0%) females over an observation time of 62,813 person-years. The time spent on- vs. off- maintenance lithium, lamotrigine, quetiapine, or olanzapine was statistically significant upon adjustment among either sex for reducing the rate of bipolar rehospitalizations. Adjusted sex-specific statistically significant associations were also observed. Among females, the time on- (vs. off-) long-acting injectable risperidone reduced the rate of bipolar rehospitalizations by 73% (56–84%), carbamazepine by 44% (18–62%), aripiprazole by 29% (13–42%), and valproate by 23% (11–33%); whereas among males, ziprasidone by 65% (41–79%). Conclusion: The effectiveness of most maintenance therapies is generally comparable and uniform among both males and females. Despite some statistically significant sex-specific associations, estimates for each drug were fairly consistent between sexes.

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Introductioncontrasting

confidence: 70%

Sex-Specific Associations Between Bipolar Disorder Pharmacological Maintenance Therapies and Inpatient Rehospitalizations: A 9-Year Swedish National Registry Study

2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…The operationalization of gender in the selected publication varies, ranging from generic definitions to specific methodological operationalization. For example, Ragazan et al [ 29 ] addressed the dimension of gender identity using a broad definition of gender.…”

Section: Resultsmentioning

confidence: 99%

Operationalization and Reporting Practices in Manuscripts Addressing Gender Differences in Biomedical Research: A Cross-Sectional Bibliographical Study

Hurk

Hiltner

Oertelt‐Prigione

2022

IJERPH

View full text Add to dashboard Cite

Historically, authors in the biomedical field have often conflated the terms sex and gender in their research significantly limiting the reproducibility of the reported results. In the present study, we investigated current reporting practices around gender in biomedical publications that claim the identification of “gender differences”. Our systematic research identified 1117 articles for the year 2019. After random selection of 400 publications and application of inclusion criteria, 302 articles were included for analysis. Using a systematic evaluation grid, we assessed the provided methodological detail in the operationalization of gender and the provision of gender-related information throughout the manuscript. Of the 302 articles, 69 (23%) solely addressed biological sex. The remaining articles investigated gender, yet only 15 (6.5%) offered reproducible information about the operationalization of the gender dimension studied. Followingly, these manuscripts also provided more detailed gender-specific background, analyses and discussions compared to the ones not detailing the operationalization of gender. Overall, our study demonstrated persistent inadequacies in the conceptual understanding and methodological operationalization of gender in the biomedical field. Methodological rigor correlated with more nuanced and informative reporting, highlighting the need for appropriate training to increase output quality and reproducibility in the field.

show abstract

“…У женщин в структуре заболевания больший удельный вес занимают именно депрессивные фазы [32][33][34]. Это сказывается на общем количестве дней нетрудоспособности в году, социальном функционировании и качестве жизни [26,35].…”

Section: Quality Of Life Assessmentunclassified

Gender differences in the clinical course of depression in bipolar disorder

Tyuvina

Stolyarova

Morozova

et al. 2021

RJTAO

View full text Add to dashboard Cite

Gender influence on the bipolar disorder inpatient length of stay in Sweden, 2005–2014: A register-based study

Cited by 10 publications

References 54 publications

Sex-Specific Associations Between Bipolar Disorder Pharmacological Maintenance Therapies and Inpatient Rehospitalizations: A 9-Year Swedish National Registry Study

Sex-Specific Associations Between Bipolar Disorder Pharmacological Maintenance Therapies and Inpatient Rehospitalizations: A 9-Year Swedish National Registry Study

Operationalization and Reporting Practices in Manuscripts Addressing Gender Differences in Biomedical Research: A Cross-Sectional Bibliographical Study

Gender differences in the clinical course of depression in bipolar disorder

Contact Info

Product

Resources

About