Gender in the Pharmacy: Does It Matter?

Kaiser, Jocelyn

doi:10.1126/science.308.5728.1572

Cited by 51 publications

(30 citation statements)

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“…tors (Claudel et al, 2007;Kaiser, 2005;Waxman and Holloway, 2009). Among them, genetic and environmental factors such as biological sex and light-dark cycles can (Kato et al, 1962;Matsunaga, 2009).…”

mentioning

confidence: 99%

Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses

et al. 2011

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mentioning

confidence: 99%

Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses

et al. 2011

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“…[1][2][3][4][5][6] A recent analysis of the German pharmacovigilance database, for example, demonstrated gender-specific differences in the frequency of hospital admissions caused by ADRs secondary to the use of diuretics. 7,8 In that study, two-thirds of serious ADRs related to diuretics occurred in women.…”

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confidence: 99%

Gender Is an Important Determinant of the Disposition of the Loop Diuretic Torasemide

Werner

Heinbüchner

et al. 2010

The Journal of Clinical Pharma

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Signals from pharmacovigilance studies indicate that women are at higher risk for adverse drug reactions (ADRs) due to diuretics. Despite the long‐term use of torasemide, there are few studies investigating gender differences of torasemide pharmacokinetics in the hospital setting. Therefore, torasemide pharmacokinetics were investigated in 90 patients (45 women, 45 men) during steady‐state conditions. Torasemide elimination was significantly reduced in women compared with men (eg, body‐weight‐normalized area under the concentration‐time curve: 42.1 ± 20.4 vs 30.9 ± 10.3 kg•h/L; P < .001). Among the investigated genetic factors [SLC22A11(OAT4), SLCO1B1(OATP1B1), CYP2C9], only the SLCO1B1c.521T>C polymorphism had a significant influence on torasemide pharmacokinetics. Using cell lines expressing OATP1B1, the authors identified torasemide as OATP1B1 substrate (Km = 6.2 μM) with a significant reduction of uptake by the 521C‐variant. Taken together, gender differences in torasemide pharmacokinetics are likely to contribute to a higher rate of ADRs in women, which has, for example, been observed in a German Pharmacovigilance Project with 66% of hospitalizations due to torasemide ADRs occurring in women.

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“…34 Por exemplo, anti-histamínicos vendidos livremente e testados inicialmente em homens, podem levar a arritmias cardíacas potencialmente fatais nas mulheres. 35 É importante apontar que nenhum mecanismo autocorretivo de pesquisa científica entrou em cena para corrigir a abordagem de gênero na pesquisa médica. Parece bastante evidente que estudar drogas em populações não-representativas é apenas má ciência.…”

Section: O Gênero Nos Resultados Da Ciênciaunclassified

Mais mulheres na ciência: questões de conhecimento

Schiebinger¹

2008

Hist. cienc. saude-Manguinhos

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Gender in the Pharmacy: Does It Matter?

Cited by 51 publications

References 0 publications

Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses

Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses

Gender Is an Important Determinant of the Disposition of the Loop Diuretic Torasemide

Mais mulheres na ciência: questões de conhecimento

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