Gender disparity in hepatocellular carcinoma recurrence after curative hepatectomy

Liang, Tianyi; He, Yongfei; Mo, Shutian; Chen, Zijun; Liao, Xiwen; Zhou, Xin; Yang, Chengkun; Zhao, Shuqi; Han, Chuangye; Zhu, Guangzhi; Su, Hao; Ye, Xinping; Peng, Tao

doi:10.1016/j.aohep.2022.100695

Cited by 22 publications

(12 citation statements)

References 29 publications

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“…We examined the factors and studied the mortality rate in HCC patients in the Upper Northern of Thailand. We found that in the univariable analyses, being male, smoking history, alcohol-use history are well known mortality risk factors for HCC which are consistent with those from other studies [42,43,44,45], but disagree with [46]. Meanwhile regional and metastasized stages are also mortality risk factors for HCC which agree with those from other studies [47,48].…”

Section: Discussionsupporting

confidence: 88%

“…First of all, we use a very large clinical data of six thousands HCC patients diagnosed during 1998-2018 to investigate mortality and survival rates on HCC patients. Even though there are many investigations on risk factors to survival rate of HCC patients [47,42,44,43,48,45], this work was the first study on an impact of evolution of imaging diagnosis technology toward mortality and survival rates on HCC patients. This could be a guideline to other hospitals to implement advanced technology on imaging diagnosis in order to increase a survival rate on HCC patients.…”

Section: Discussionmentioning

confidence: 99%

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Prediction of Survival and Analysis of prognostic factors for Hepatocellular Carcinoma: A 20-year of Imaging Diagnosis in Upper Northern Thailand

Nakharutai

Chitapanarux

Traisathit

et al. 2023

Preprint

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Background: To evaluate survival rates of hepatocellular carcinoma (HCC), the Chiang Mai Cancer Registry provided characteristics data of 6276 HCC patients diagnosed between 1998-2020 based on evolution of imaging diagnosis. Evolution can be separated into four cohorts, namely, cohort 1 (1990-2005) when we had ultrasound (US) and single-phase computed tomography (CT), cohort 2 (2006-2009) when one multi-phase CT and one magnetic resonance imaging (MRI) were added, cohort 3 (2010-2015) when MRI with LI-RADS was added, and finally, cohort 4 (2016-2020) when two upgraded MRIs with LI-RADS were added. Methods: Cox proportional hazard models were used to determine the relation between death and risk factors including methods of imagining diagnosis, gender, age of diagnosis, tumor stages, history of smoking and alcohol-use, while Kaplan–Meier curves were used to calculate survival rates. Results: The median age of diagnosis was 57.0 years (IQR: 50.0-65.0) and the median survival time was 5.8 months (IQR: 1.9–26.8) during the follow-up period. In the univariable analysis, all factors were all associated with a higher risk of death in HCC patients except age of diagnosis. In a multivariable analysis, elderly age at diagnosis, regional and metastatic stages and advanced methods of imagining diagnosis during cohorts 2 and 3 were independently associated with the risk of death in HCC patients. The survival rate of patients diagnosed during cohort 4 was significantly higher than the other cohorts. Conclusion: As a significantly increasing survival rate of HCC patients, advanced methods of imagining diagnosis in cohort 4 can be recommended as a guideline of imaging diagnosis.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Prediction of Survival and Analysis of prognostic factors for Hepatocellular Carcinoma: A 20-year of Imaging Diagnosis in Upper Northern Thailand

Nakharutai

Chitapanarux

Traisathit

et al. 2023

Preprint

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“…The sex disparity in HCC survival outcome was well documented before, whereby females' survival outcome was significantly better than that of males. 50,51 In this study, OS in the female HCC patient group was higher than that of the male group, but the difference was not statistically significant. There could be some reasons for this.…”

Section: Hepatocellular Carcinoma Patients' Survival Outcomecontrasting

confidence: 62%

Survival Outcome and Prognostic Factors Among Patients With Hepatocellular Carcinoma: A Hospital-Based Study

Le¹,

Nguyen²,

Nguyen³

et al. 2023

Clin Med Insights Oncol

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Background: Hepatocellular carcinoma (HCC) is a leading cancer with very high incidence and mortality and low survival rate in Vietnam and worldwide. This study aimed to investigate the survival outcome and its prognostic factors among HCC patients. Methods: This is a retrospective descriptive study on patients newly diagnosed with HCC at Hanoi Oncology Hospital, Vietnam from January 2018 to December 2020. Overall survival (OS) was calculated by the Kaplan-Meier method. Log-rank test and Cox regression were used to investigate the association among patients’ OS and their diagnosis and treatment factors. Results: A total of 674 patients were included. The median OS was 10.0 months. The survival rates at 6, 12, 24, and 36 months were 57.3%, 46.6%, 34.8%, and 29.7%, respectively. The initial performance status (PS), Child-Pugh score, and Barcelona Clinic Liver Cancer (BCLC) stage at the time of diagnosis are prognostic factors of HCC OS. A total of 451 (66.8%) patients have died, most of them (375 equally 83.1%) died at home, and only 76 (16.9%) died at hospital. Hepatocellular carcinoma patients living in the rural area more likely died at home than those living in the urban area (85.9% vs 74.8%, P = .007). Conclusions: Hepatocellular carcinoma has a poor prognosis with low OS. Performance status, Child-Pugh score, and BCLC stage were the independent prognostic factors for the survival outcome of HCC patients. The fact that most HCC patients died at home suggested that home-based hospice care needs to be paid special attention.

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“…of 1.48 (95% C.I. 1.08–2.02) for early recurrence after surgical resection [ 47 ], Yang et al reported that the male gender has an H.R. of 2.46 (95% C.I.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Hepatocellular Carcinoma Early Recurrence in Patients Treated with Surgical Resection or Ablation Treatment: A Single-Center Experience

et al. 2022

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Introduction: Hepatocellular carcinoma (HCC) is the sixth most diagnosed malignancy and the fourth leading cause of cancer-related death worldwide, with poor overall survival despite available curative treatments. One of the most crucial factors influencing survival in HCC is recurrence. The current study aims to determine factors associated with early recurrence of HCC in patients with BCLC Stage 0 or Stage A treated with surgical resection or local ablation. Materials and Methods: We retrospectively enrolled 58 consecutive patients diagnosed with HCC within BCLC Stage 0 or Stage A and treated either by surgical resection or local ablation with maximum nodule diameter < 50 mm. In the first year of follow-up after treatment, imaging was performed regularly one month after treatment and then every three months. Each case was discussed collectively by the Liver Multidisciplinary Group to decide diagnosis, treatment, follow-up, and disease recurrence. Variables resulting in statistically significant difference were then studied by Cox regression analysis; univariately and then multivariately based on forward stepwise Cox regression. Results are represented in hazard ratio (H.R.) with 95% confidence interval (C.I.). Results: There was no statistically significant difference in recurrence rates (34.8 vs. 45.7%, log-rank test, p = 0.274) between patients undergoing surgical resection and local ablation, respectively. Early recurrence was associated with male gender (HR 2.5, 95% C.I. 1.9–3.1), nodule diameter > 20 mm (HR 4.5, 95% C.I. 3.9–5.1), platelet count < 125 × 103 cell/mm3 (HR 1.6, 95% C.I. 1.2–1.9), platelet-lymphocyte ratio < 95 (HR 2.1, 95% C.I. 1.7–2.6), lymphocyte-monocyte ratio < 2.5 (HR 1.9, 95% C.I. 1.4–2.5), and neutrophil-lymphocyte ratio > 2 (HR 2.7, 95% C.I. 2.2–3.3). Discussion and Conclusions: Our results are in line with the current literature. Male gender and tumor nodule dimension are the main risk factors associated with early HCC recurrence. Platelet count and other combined scores can be used as predictive tools for early HCC recurrence, although more studies are needed to define cut-offs.

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Gender disparity in hepatocellular carcinoma recurrence after curative hepatectomy

Cited by 22 publications

References 29 publications

Prediction of Survival and Analysis of prognostic factors for Hepatocellular Carcinoma: A 20-year of Imaging Diagnosis in Upper Northern Thailand

Prediction of Survival and Analysis of prognostic factors for Hepatocellular Carcinoma: A 20-year of Imaging Diagnosis in Upper Northern Thailand

Survival Outcome and Prognostic Factors Among Patients With Hepatocellular Carcinoma: A Hospital-Based Study

Predictors of Hepatocellular Carcinoma Early Recurrence in Patients Treated with Surgical Resection or Ablation Treatment: A Single-Center Experience

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