In an interesting paper, Tavris et al. 1 confirmed the gender-related differences in treatment of non-STsegment elevation myocardial infarction (NSTEMI) patients, where female patients were less likely to receive coronary intervention and acute medical treatments. We feel that this gender difference in cardiac care is welldemonstrated and the scientific community should focus on studying barriers and developing strategies to reduce any differential care. Indeed, Tavris's study 1 complements previous studies that have reported gender-related differences in survival-to-hospital-discharge rates for cardiac arrest 2 and ST-segment elevation myocardial infarction (STEMI) patients 3,4 that may be partially attributed to receiving different in-hospital medications and procedures or inequity in access to care. 2 -4 Women are less likely to have their myocardial infarction (MI) diagnosed in the emergency department, and are less likely to receive invasive diagnostics 5 -7 and treatment such as percutaneous coronary intervention (PCI) (23.9% women vs 39.9% men), 3,4 which may account for poorer outcomes 6,7 and increased mortality with MI (12.7% in women vs 9.7% in men). 3,4 Women had 24% lower odds of receiving PCI when they were taken to hospitals with PCI availability. 4 Even more impressive is the fact that when women received the PCI intervention, the difference in mortality rates between genders disappeared. 4 Using our local data of 5000 cardiac arrests per year, we have demonstrated significantly lower survival-to-discharge rates of 3.9% for women vs 6.4% for men (unpublished data). The observed gender bias in inhospital care may be attributed to inequality in knowledge transfer. In the absence of sociological models that suggest a rationale for differences in health outcomes, we speculate that there may be gender-related barriers that contribute to differential care and unfavorable outcomes in women presenting with STEMI, NSTEMI, or cardiac arrest. These barriers may include differential application of guidelines, unique gender-specific knowledge gaps, attitudes and behaviors in all caregivers that affect preferential prescribing or access to care, and potential barriers to care that affect women more than men. Studies that would explore the perceived barriers through qualitative and quantitative research are needed to identify interventions that might be helpful to reduce any differential care.