Gender differential in inclination to donate brain for research among Nigerians: the IBADAN Brain Bank Project

Akinyemi, Rufus; Ojagbemi, Akin; Akinyemi, Joshua; Salami, Ayodeji; Olopade, Funmilayo; Farombi, Temitope; Nweke, Michael; Uvere, Ezinne; Aridegbe, Mayowa; Balogun, James A.; Ogbole, Godwin; Jegede, Ayodele Samuel; Kalaria, Rajesh N.; Ogunniyi, Adesola; Owolabi, Mayowa; Arulogun, Oyedunni

doi:10.1007/s10561-019-09769-4

Cited by 9 publications

(14 citation statements)

References 27 publications

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“…Our study findings indicate that participants had lower levels of awareness about brain sample donation for research and low levels of willingness to donate brain samples (20%) as compared to blood samples (75%). These findings are consistent with findings from the IBADAN Brain Bank Project in Nigeria in which the awareness related to brain donation was found to be lower than for other organs [ 10 ]. There is generally low level of awareness of biobanking and organ donation globally, and brain donation for research is still an evolving concept in sSA [ 2 , 18 ].…”

Section: Discussionsupporting

confidence: 91%

“…brain for research. However, the awareness levels of participants in the IBADAN Brain Bank Project was higher as compared to ours [10]. This could be attributed to the higher age group of participants in the IBADAN Brain Bank Project (mean age 46.3 years), though these differences may also stem from different cultural attitudes towards donation, religious beliefs or low [19].…”

Section: Plos Onecontrasting

confidence: 64%

“…In our study, approximately a third had heard of blood sample donation for research, whereas only about a tenth had heard of collecting and storing brain for research. However, the awareness levels of participants in the IBADAN Brain Bank Project was higher as compared to ours [ 10 ]. This could be attributed to the higher age group of participants in the IBADAN Brain Bank Project (mean age 46.3 years), though these differences may also stem from different cultural attitudes towards donation, religious beliefs or low levels of trust in public institutions (which may result from previous breaches of trust) as highlighted by Tindana et al (2012) [ 19 ].…”

Section: Discussionmentioning

confidence: 69%

“…However, some studies have indicated that biobanking-knowledge, type of donated tissue, purpose of research, safety of the data, preferred type of consent, and trust towards biobanks are all influential factors related to willingness to donate [ 7 – 9 ]. Studies conducted in the African sub region such as Nigeria indicates a high level of awareness but poor willingness towards organ donation such as brain, among older Nigerians [ 10 ]. Nevertheless, studies conducted in Europe and America indicate a generally positive attitude towards biobanking and a high willingness to donate, but these concepts have not been substantially investigated within the African sub region [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biological sample donation and informed consent for neurobiobanking: Evidence from a community survey in Ghana and Nigeria

et al. 2022

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Introduction Genomic research and neurobiobanking are expanding globally. Empirical evidence on the level of awareness and willingness to donate/share biological samples towards the expansion of neurobiobanking in sub-Saharan Africa is lacking. Aims To ascertain the awareness, perspectives and predictors regarding biological sample donation, sharing and informed consent preferences among community members in Ghana and Nigeria. Methods A questionnaire cross-sectional survey was conducted among randomly selected community members from seven communities in Ghana and Nigeria. Results Of the 1015 respondents with mean age 39.3 years (SD 19.5), about a third had heard of blood donation (37.2%, M: 42.4%, F: 32.0%, p = 0.001) and a quarter were aware of blood sample storage for research (24.5%; M: 29.7%, F: 19.4%, p = 0.151). Two out of ten were willing to donate brain after death (18.8%, M: 22.6%, F: 15.0%, p<0.001). Main reasons for unwillingness to donate brain were; to go back to God complete (46.6%) and lack of knowledge related to brain donation (32.7%). Only a third of the participants were aware of informed consent (31.7%; M: 35.9%, F: 27.5%, p<0.001). Predictors of positive attitude towards biobanking and informed consent were being married, tertiary level education, student status, and belonging to select ethnic groups. Conclusion There is a greater need for research attention in the area of brain banking and informed consent. Improved context-sensitive public education on neurobiobanking and informed consent, in line with the sociocultural diversities, is recommended within the African sub region.

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Section: Discussionsupporting

confidence: 91%

Section: Plos Onecontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biological sample donation and informed consent for neurobiobanking: Evidence from a community survey in Ghana and Nigeria

et al. 2022

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The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact

Kalaria,

Maestre,

Mahinrad

et al. 2024

Alzheimer's & Dementia

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Two of every three persons living with dementia reside in low‐ and middle‐income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia care costs occur in high‐income countries (HICs), with dementia research predominantly focusing on HICs. This imbalance necessitates LMIC‐focused research to ensure that characterization of dementia accurately reflects the involvement and specificities of diverse populations. Development of effective preventive, diagnostic, and therapeutic approaches for dementia in LMICs requires targeted, personalized, and harmonized efforts. Our article represents timely discussions at the 2022 Symposium on Dementia and Brain Aging in LMICs that identified the foremost opportunities to advance dementia research, differential diagnosis, use of neuropsychometric tools, awareness, and treatment options. We highlight key topics discussed at the meeting and provide future recommendations to foster a more equitable landscape for dementia prevention, diagnosis, care, policy, and management in LMICs.Highlights Two‐thirds of persons with dementia live in LMICs, yet research and costs are skewed toward HICs. LMICs expect dementia prevalence to more than double, accompanied by socioeconomic disparities. The 2022 Symposium on Dementia in LMICs addressed advances in research, diagnosis, prevention, and policy. The Nairobi Declaration urges global action to enhance dementia outcomes in LMICs.

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The top 100 most-cited articles citing human brain banking from 1970 to 2020: a bibliometric analysis

et al. 2020

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Gender differential in inclination to donate brain for research among Nigerians: the IBADAN Brain Bank Project

Abstract: Background: Laboratory-based studies of neurological disease patterns and mechanisms are sparse in sub-Saharan Africa. However, availability of human brain tissue resource depends on

Cited by 9 publications

References 27 publications

Biological sample donation and informed consent for neurobiobanking: Evidence from a community survey in Ghana and Nigeria

Biological sample donation and informed consent for neurobiobanking: Evidence from a community survey in Ghana and Nigeria

The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact

The top 100 most-cited articles citing human brain banking from 1970 to 2020: a bibliometric analysis

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