Gender differences in the relationship of childhood trauma and the course of illness in schizophrenia

Kocsis-Bogár, Krisztina; Mészáros, Veronika; Perczel-Forintos, Dóra

doi:10.1016/j.comppsych.2018.01.007

Cited by 23 publications

(8 citation statements)

References 37 publications

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“…In a recent study by Comacchio et al with 44 patients with schizophrenia, PA and SA in childhood were significantly associated with an earlier age of disease onset only in women with schizophrenia (Comacchio et al, 2020). In a study investigating 53 female and 49 male patients with schizophrenia, the disease started significantly early in patients reporting PA, regardless of sex, and PA predicted the early disease onset only in female patients (Kocsis-Bogár et al, 2018). However, two studies in patients with schizophrenia reported no relationship between AoO of the disease and CT (Baudin et al, 2016; Rajkumar, 2015).…”

Section: Discussionmentioning

confidence: 98%

The effect of childhood trauma on age of onset in patients with schizophrenia

İngeç

Kılıçaslan

2020

Int J Soc Psychiatry

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Purpose: Childhood trauma (CT) has been shown to affect the etiology and clinical features of schizophrenia. In this study, it was aimed to investigate the effects of CT on the age of onset (AoO) and clinical features of the disease by considering factors such as family history, head trauma, birth trauma, alcohol and substance abuse that may affect AoO of the disease. Methods: The sample comprising 200 patients admitted to the outpatient and inpatient care at the Izmir Katip Çelebi University, Atatürk Education and Research Hospital psychiatry clinic, were included in the study. Socio-demographic information form, Positive and Negative Syndrome Scale (PANSS), Childhood Trauma Questionnaire-Short Form (CTQ-SF) and subscale of Mini-International Neuropsychiatric Interview (MINI) were applied. Results: All types of trauma, except physical abuse, were found related to the disease onset age earlier. It was also detected that the factors of head trauma, birth complication, presence of an individual diagnosed with schizophrenia in the family and migration history were not related to AoO of the disease. On the other hand, it was found that physical, emotional and sexual abuses lead to more positive psychotic symptoms, and all types of CT increase the severity of disease and the risk of suicide. Conclusion: This study draws attention to the etiological importance of CT in schizophrenia as an environmental factor by showing that it affects AoO of the disease along with symptomatology. Future studies should focus on the pathogenesis of CT in schizophrenia and the interaction between CT and biological and genetic predisposition.

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Section: Discussionmentioning

confidence: 98%

The effect of childhood trauma on age of onset in patients with schizophrenia

İngeç

Kılıçaslan

2020

Int J Soc Psychiatry

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“…Above and beyond the relationships between these genetic and environmental factors on cognition, these factors may also be important for the degree to which individuals can compensate for the deleterious outcomes of CT. Emerging research suggests that gender could be implicated in the relationship between CT and cognitive function in patients with psychosis (Pruessner et al, 2017a; Kocsis-Bogar et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

The role of childhood trauma in cognitive performance in schizophrenia and bipolar disorder – A systematic review

Dauvermann

Donohoe

2019

Schizophrenia Research: Cognition

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Childhood trauma (CT) has repeatedly been associated with cognitive deficits in patients with psychosis but many inconsistencies have been reported so that the nature of the relationship remains unclear. The purpose of this review was to better characterize the contribution of CT to cognitive deficits by considering the type, severity and frequency of childhood traumatic events and their relationships with psychosis at all stages.Relevant studies were identified via electronic and manual literature searches and included original studies that investigated the relationship between CT and higher cognitive performance or social cognitive performance in patients with schizophrenia, bipolar disorder and psychosis at all stages of the illness stages (i.e. ultra-high risk, first episode or chronic phase).Overall, a majority of studies reported that patients who experienced CT displayed deficits in general cognitive ability compared to patients with psychosis without such a history. Associations between CT and other cognitive function were more mixed. When comparing patient groups, the association between CT and cognitive function was more inconsistent in patients with chronic schizophrenia than in healthy participants, ultra-high risk individuals, first-episode patients and patients with chronic bipolar disorder.In understanding the variability in the reported relationships between CT and cognition across study populations, we highlight the variety of questionnaires used and discuss the likelihood of there being differences in cognitive function based on specific stressors, severity and frequency. Finally, we consider future research steps that may shed light on psychobiological mechanisms underlying CT and cognitive performance in patients with psychosis.

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“…Another study revealed that patients with a history of abuse, regardless of gender, have a significantly younger age of onset. In contrast, physical trauma appears to be a critical factor in accelerating the onset of schizophrenia, particularly in females [40]. In comparison, Rajkumar (2015) reported that age of onset was not correlated with the ACE scores [29].…”

Section: Study Patientsmentioning

confidence: 94%

Prevalence and clinical implication of adverse childhood experiences and their association with substance use disorder among patients with schizophrenia

Yousef

Mohamed

Eldeeb

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Background Adverse childhood experiences (ACEs) and substance use disorder (SUD) are well-known risk factors for psychosis and dramatically affect schizophrenia. In this research, we aimed to measure the prevalence of adverse childhood experiences and substance use disorder in patients with schizophrenia and assess the effect of ACEs on the clinical presentation and overall functioning and the association between them and SUD in patients with schizophrenia. A cross-sectional study included a random sample of 165 schizophrenic patients who were examined by doing drug screen in urine, structured questionnaire to collect Socioeconomic characteristics, history of schizophrenia, structured clinical interview for Diagnostic and Statistical Manual of Mental Disorders-fifth edition, Positive and Negative Syndrome Scale (PANSS), Adverse Childhood Experiences International Questionnaire (ACE-IQ), World Health Organization Disability Assessment Schedule 2.0, compliance rating scale, addiction severity index fifth edition (ASI) for individuals with positive urine drug screen. Results Only 14.4% of the studied patients had no adverse childhood experiences. The prevalence of positive substance abuse screening was 18.2%. There were statistically significant negative correlations between total ACE score and educational level, socioeconomic level, and the onset of schizophrenia. On the other hand, statistically significant positive correlations were found between the total ACE score and PANSS score and ASI score. The first most frequent ACE was significantly associated with female gender, lower education levels, low and middle socioeconomic classes, lifetime substance use, smokers, and positive drug screening. Emotional neglect and contact sexual abuse were significantly associated with positive drug screening. At the same time, Physical abuse was significantly associated with both lifetime substance use and positive drug screening. Conclusion The current study’s findings indicate that childhood adverse experiences and substance abuse are prevalent problems in patients with schizophrenia. Given that there is an association between both issues, they may affect the symptomatology of the disorder, the prognosis, and the therapeutic plan. It is advised that a greater emphasis on and identification of childhood trauma and drug use disorder may be a necessary step in assessing patients with schizophrenia.

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Gender differences in the relationship of childhood trauma and the course of illness in schizophrenia

Cited by 23 publications

References 37 publications

The effect of childhood trauma on age of onset in patients with schizophrenia

The effect of childhood trauma on age of onset in patients with schizophrenia

The role of childhood trauma in cognitive performance in schizophrenia and bipolar disorder – A systematic review

Prevalence and clinical implication of adverse childhood experiences and their association with substance use disorder among patients with schizophrenia

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