Gender differences in the perception of asthma respiratory symptoms in five Latin American countries

Borges, Rodrigo Cerqueira; Alith, Marcela Batan; Nascimento, Oliver Augusto; Jardim, José Roberto

doi:10.1080/02770903.2021.1922914

Cited by 5 publications

(5 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 21–23 This issue warrants further study, but a detailed analysis of uncontrolled asthma in minority adolescents is beyond the scope of the current study. In the present study, female sex was associated with an increased risk of uncontrolled asthma, consistent with previously published studies 24 , 25 reporting that adolescent females were more likely to report severe and uncontrolled asthma, with frequent visits to healthcare professionals. The obesity-related asthma phenotype in female patients is associated with severe symptoms and preserved lung function; molecular mechanisms include oxidative stress, airway neutrophil activation, and increased innate immune activity.…”

Section: Discussionsupporting

confidence: 92%

Racial and Ethnic Minorities at the Highest Risk of Uncontrolled Moderate-to-Severe Asthma: A United States Electronic Health Record Analysis

George¹,

Camargo²,

Burnette³

et al. 2023

JAA

View full text Add to dashboard Cite

Purpose The identification of risk factors associated with uncontrolled moderate-to-severe asthma is important to improve asthma outcomes. Aim of this study was to identify risk factors for uncontrolled asthma in United States cohort using electronic health record (EHR)-derived data. Patients and Methods In this retrospective real-world study, de-identified data of adolescent and adult patients (≥12 years old) with moderate-to-severe asthma, based on asthma medications within 12 months prior to asthma-related visit (index date), were extracted from the Optum ® Humedica EHR. The baseline period was 12 months prior to the index date. Uncontrolled asthma was defined as ≥2 outpatient oral corticosteroid bursts for asthma or ≥2 emergency department visits or ≥1 inpatient visit for asthma. A Cox proportional hazard model was applied. Results There were 402,403 patients in the EHR between January 1, 2012, and December 31, 2018, who met the inclusion criteria and were analyzed. African American (AA) race (hazard ratio [HR]: 2.08), Medicaid insurance (HR: 1.71), Hispanic ethnicity (HR: 1.34), age of 12 to <18 years (HR 1.20), body mass index of ≥35 kg/m 2 (HR: 1.20), and female sex (HR 1.19) were identified as risk factors associated with uncontrolled asthma ( P < 0.001). Comorbidities characterized by type 2 inflammation, including a blood eosinophil count of ≥300 cells/μL (as compared with eosinophil <150 cells/μL; HR: 1.40, P < 0.001) and food allergy (HR: 1.31), were associated with a significantly higher risk of uncontrolled asthma; pneumonia was also a comorbidity associated with an increased risk (HR: 1.35) of uncontrolled asthma. Conversely, allergic rhinitis (HR: 0.84) was associated with a significantly lower risk of uncontrolled asthma. Conclusion This large study demonstrates multiple risk factors for uncontrolled asthma. Of note, AA and Hispanic individuals with Medicaid insurance are at a significantly higher risk of uncontrolled asthma versus their White, non-Hispanic counterparts with commercial insurance.

show abstract

Section: Discussionsupporting

confidence: 92%

Racial and Ethnic Minorities at the Highest Risk of Uncontrolled Moderate-to-Severe Asthma: A United States Electronic Health Record Analysis

George¹,

Camargo²,

Burnette³

et al. 2023

JAA

View full text Add to dashboard Cite

show abstract

“…Evidence suggests that women perceive their asthma as more symptomatic than men and report more frequent, severe, and bothersome symptoms, even if the severity and level of asthma control are similar 4 . Compared with men, women also report poorer quality of life and greater symptom impact, including more limitations on sports, social activities, sleep, and day-to-day activities 8 . It may be for these reasons that women are more likely than men to report their symptoms to a HCP 8 .…”

Section: Gender Differences In Patient Health Behaviors Patient Repor...mentioning

confidence: 98%

“…Compared with men, women also report poorer quality of life and greater symptom impact, including more limitations on sports, social activities, sleep, and day-to-day activities 8 . It may be for these reasons that women are more likely than men to report their symptoms to a HCP 8 . Men may also understate their symptoms and be reluctant to seek HCP support due to societal expectations that men should not complain about their health 9 .…”

Section: Gender Differences In Patient Health Behaviors Patient Repor...mentioning

confidence: 98%

Addressing sex and gender to improve asthma management

Boulet

Lavoie

Raherison‐Semjen

et al. 2022

npj Prim. Care Respir. Med.

View full text Add to dashboard Cite

Sex (whether one is ‘male’ or ‘female’, based on biological characteristics) and gender (defined by socially constructed roles and behaviors) influence asthma diagnosis and management. For example, women generally report more severe asthma symptoms than men; men and women are exposed to different asthma-causing triggers; men tend to be more physically active than women. Furthermore, implicit, often unintended gender bias by healthcare professionals (HCPs) is widespread, and may result in delayed asthma diagnosis, which can be greater in women than men. The sex and gender of the HCP can also impact asthma management. Pregnancy, menstruation, and menopause can all affect asthma in several ways and may be associated with poor asthma control. This review provides guidance for considering sex- and gender-associated impacts on asthma diagnosis and management and offers possible approaches to support HCPs in providing personalized asthma care for all patients, regardless of their sex or gender.

show abstract

“…Searching for down-modulation of some groups of the main mechanisms is important and a valid approach; however, we see a window for improvement. As we mentioned earlier in the text, asthma symptoms are more prominent in adult women than in men [ 8 , 219 ]. However, many of the preclinical data using asthma models were developed using male mice and rats and used OVA for sensitization/challenges.…”

Section: Perspectives Of Novel Formulations Containing Flavonoids For...mentioning

confidence: 99%

“…Female asthma patients report more asthma symptoms and poorer disease control than male patients. As a result, there is a higher impact on daily activities and an increased number of visits to health professionals by female than male asthma patients [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Controlled Delivery Systems in Asthma: Preclinical Development of Flavonoid-Based Treatments

et al. 2022

View full text Add to dashboard Cite

Asthma is a chronic disease with increasing prevalence and incidence, manifested by allergic inflammatory reactions, and is life-threatening for patients with severe disease. Repetitive challenges with the allergens and limitation of treatment efficacy greatly dampens successful management of asthma. The adverse events related to several drugs currently used, such as corticosteroids and β-agonists, and the low rigorous adherence to preconized protocols likely compromises a more assertive therapy. Flavonoids represent a class of natural compounds with extraordinary antioxidant and anti-inflammatory properties, with their potential benefits already demonstrated for several diseases, including asthma. Advanced technology has been used in the pharmaceutical field to improve the efficacy and safety of drugs. Notably, there is also an increasing interest for the application of these techniques using natural products as active molecules. Flavones, flavonols, flavanones, and chalcones are examples of flavonoid compounds that were tested in controlled delivery systems for asthma treatment, and which achieved better treatment results in comparison to their free forms. This review aims to provide a comprehensive understanding of the development of novel controlled delivery systems to enhance the therapeutic potential of flavonoids as active molecules for asthma treatment.

show abstract

Gender differences in the perception of asthma respiratory symptoms in five Latin American countries

Cited by 5 publications

References 56 publications

Racial and Ethnic Minorities at the Highest Risk of Uncontrolled Moderate-to-Severe Asthma: A United States Electronic Health Record Analysis

Racial and Ethnic Minorities at the Highest Risk of Uncontrolled Moderate-to-Severe Asthma: A United States Electronic Health Record Analysis

Addressing sex and gender to improve asthma management

Therapeutic Potential of Controlled Delivery Systems in Asthma: Preclinical Development of Flavonoid-Based Treatments

Contact Info

Product

Resources

About