Gender Differences in the Long-Chain Polyunsaturated Fatty Acid Status: Systematic Review of 51 Publications

Lohner, Szimonetta; Fekete, Katalin; Marosvölgyi, Tamás; Décsi, Támas

doi:10.1159/000345599

Cited by 154 publications

(121 citation statements)

References 109 publications

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“…Interaction between ABCA1 R219K, elevated TG and sex The finding of 219K allele carriage being independently associated with higher TG concentration in women can be accounted for by serum TG being strong independent covariate of total phospholipids (30) and the knowledge that dietary long-chain polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid contribute to plasma phospholipids more in women than men, and mainly in populations with low dietary n-3 fatty acid intake (30,31) to which Turks belong. 219RK genotype, gender and elevated TG interacted in this study sample to impact CHD.…”

Section: Discussionmentioning

confidence: 99%

Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults

Çoban¹,

Onat²,

Kömürcü-Bayrak³

et al. 2013

Anadolu Kardiyol Derg

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Objective: ATP binding cassette transporter A1 (ABCA1) controls the reverse cholesterol transport. Some ABCA1 variants are correlated with serum high-density lipoprotein cholesterol (HDL-C) and other lipid concentrations. We aimed to explore the relationship of ABCA1 gene with both the lipid profile and coronary heart disease (CHD) risk. Methods: Selected 627 individuals of the Turkish Adult Risk Factor Study were genotyped for ABCA1 R219K polymorphism using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method. Student's t-test, one-way ANOVA, Chi-square test, linear and logistic regression was used for statistical analysis. Results: We demonstrated a gender-specific effect of the R219K polymorphism on plasma lipids and CHD. In men, while homozygosity of the K allele was associated with increased plasma low-density lipoprotein cholesterol (LDL-C) (p<0.05) and total cholesterol concentrations (p<0.05), carriage of this allele was associated with higher HDL-C concentrations (p<0.05) after adjustment for associated risk factors, but not with CHD. In women, however, without being related to HDL-C levels, each 219K allele was associated with 10% higher triglycerides (TG) concentrations (p<0.05). R219K heterozygosity in women independently doubled (95% CI 1.00; 3.80) the odds ratio for CHD risk in regression models, after adjustment for several variables. Interaction of TG elevation (>140 mg/dL) with CHD was demonstrated in female 219RK genotype carriers. Conclusion: R219 allele of the ABCA1 gene independently confers CHD risk in heterozygote Turkish women, not via reduced HDL-C, but interacting with elevated TG expressed by the 219K allele, but not in men. (Anadolu Kardiyol Derg 2014; 14: 18-25)

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Section: Discussionmentioning

confidence: 99%

Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults

Çoban¹,

Onat²,

Kömürcü-Bayrak³

et al. 2013

Anadolu Kardiyol Derg

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“…Lohner et al evaluated by meta-analysis publications from 1975 to 2011 that compared LC PUFA concentrations between men and women [176]. Their analysis showed significantly lower DHA in total plasma lipids (33 studies) and in plasma phospholipids (23 studies) in men than in women.…”

Section: Sex Differences In Alpha-linolenic Acid Metabolismmentioning

confidence: 99%

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Baker

Miles

Burdge

et al. 2016

Progress in Lipid Research

320

283

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“…A meta-analysis of gender differences in omega-3 PUFA levels in RBC membranes has previously reported a significantly higher DHA, but not EPA, content in RBCs in women compared with men [29]. However, a previous supplementation study, which undertook a genderspecific analysis, reported on gender difference in omega-3 index [31].…”

Section: Discussionmentioning

confidence: 96%

“…There was significant heterogeneity in the increase in EPA content of RBC membranes in response to EPA treatment, which has previously been noted in intervention studies of daily supplementation with combined EPA and DHA formulations (measured as the omega-3 index) in atherosclerotic patients [28][29], but not cancer patients. This is in contrast to the more uniform incorporation of EPA into RBC membranes observed in the healthy volunteer study of EPA-FFA by Scaioli et al [23].…”

Section: Discussionmentioning

confidence: 99%

Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases

Watson

Cockbain

Spencer

et al. 2016

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases, Prostaglandins Leukotrienes and Essential Fatty Acids, http://dx.doi.org/10.1016/j.plefa.2016.10.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractWe investigated red blood cell (RBC) PUFA profiles, and the predictive value of RBC EPA content for tumour EPA exposure and clinical outcomes, in the EMT study, a randomised trial of EPA in patients awaiting colorectal cancer (CRC) liver metastasis surgery (A.J. Cockbain et al, 2014). There was a significant increase in RBC EPA in the EPA group (n=43; median intervention 30 days; mean absolute 1.26 [±0.14]% increase; P<0.001), but not in the placebo arm (n=45). EPA incorporation varied widely in EPA users and was not explained by treatment duration or compliance.

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Gender Differences in the Long-Chain Polyunsaturated Fatty Acid Status: Systematic Review of 51 Publications

Cited by 154 publications

References 109 publications

Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults

Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases

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