Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases

Murdaca, Giuseppe; Tagliafico, Luca; Page, Elena; Paladin, Francesca; Gangemi, Sebastiano

doi:10.3390/biomedicines12051023

Cited by 4 publications

(1 citation statement)

References 125 publications

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“…Vitamin D deficiency may compromise barrier integrity and alter microbiome composition, with gut dysbiosis potentially impairing both local and pulmonary immune functions, thus heightening asthma susceptibility. Respiratory infections can disrupt the gut microbiome, decreasing bacteria that produce short-chain fatty acids (SCFAs), which in turn impacts the function and fate of immune cells, further exacerbating asthma symptoms ( 109 – 111 ).…”

Section: Vitamin D and Allergic Diseasesmentioning

confidence: 99%

Vitamin D and allergic diseases

Zhang,

Xu,

Zhu

2024

Front. Immunol.

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In recent years, the relationship between vitamin D and allergic diseases has received widespread attention. As a fat-soluble vitamin, vitamin D plays a crucial role in regulating the immune system and may influence the onset and progression of diseases such as atopic dermatitis, allergic rhinitis, and asthma. To understand the underlying mechanisms, we have summarized the current research on the association between vitamin D and allergic diseases. We also discuss the impact of vitamin D on the immune system and its role in the course of allergic diseases, particularly focusing on how vitamin D supplementation affects the treatment outcomes of these conditions. We aim to provide a theoretical basis and practical guidance for optimizing the management and treatment of allergic diseases by modulating vitamin D levels.

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Section: Vitamin D and Allergic Diseasesmentioning

confidence: 99%

Vitamin D and allergic diseases

Zhang,

Xu,

Zhu

2024

Front. Immunol.

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Genetic prediction of blood metabolites mediating the relationship between gut microbiota and Alzheimer’s disease: a Mendelian randomization study

Chen,

Jin,

Chu

et al. 2024

Front. Microbiol.

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BackgroundObservational studies have suggested an association between gut microbiota and Alzheimer’s disease (AD); however, the causal relationship remains unclear, and the role of blood metabolites in this association remains elusive.PurposeTo elucidate the causal relationship between gut microbiota and AD and to investigate whether blood metabolites serve as potential mediators.Materials and methodsUnivariable Mendelian randomization (UVMR) analysis was employed to assess the causal relationship between gut microbiota and AD, while multivariable MR (MVMR) was utilized to mitigate confounding factors. Subsequently, a two-step mediation MR approach was employed to explore the role of blood metabolites as potential mediators. We primarily utilized the inverse variance-weighted method to evaluate the causal relationship between exposure and outcome, and sensitivity analyses including Contamination mixture, Maximum-likelihood, Debiased inverse-variance weighted, MR-Egger, Bayesian Weighted Mendelian randomization, and MR pleiotropy residual sum and outlier were conducted to address pleiotropy.ResultsAfter adjustment for reverse causality and MVMR correction, class Actinobacteria (OR: 1.03, 95% CI: 1.01–1.06, p = 0.006), family Lactobacillaceae (OR: 1.03, 95% CI: 1.00–1.05, p = 0.017), genus Lachnoclostridium (OR: 1.03, 95% CI: 1.00–1.06, p = 0.019), genus Ruminiclostridium9 (OR: 0.97, 95% CI: 0.94–1.00, p = 0.027) and genus Ruminiclostridium6 (OR: 1.03, 95% CI: 1.01–1.05, p = 0.009) exhibited causal effects on AD. Moreover, 1-ribosyl-imidazoleacetate levels (−6.62%), Metabolonic lactone sulfate levels (2.90%), and Nonadecanoate (19:0) levels (−12.17%) mediated the total genetic predictive effects of class Actinobacteria on AD risk. Similarly, 2-stearoyl-GPE (18:0) levels (−9.87%), Octadecanedioylcarnitine (C18-DC) levels (4.44%), 1-(1-enyl-stearoyl)-2-oleoyl-GPE (p-18:0/18:1) levels (38.66%), and X-23639 levels (13.28%) respectively mediated the total genetic predictive effects of family Lactobacillaceae on AD risk. Furthermore, Hexadecanedioate (C16-DC) levels (5.45%) mediated the total genetic predictive effects of genus Ruminiclostridium 6 on AD risk; Indole-3-carboxylate levels (13.91%), X-13431 levels (7.08%), Alpha-ketoglutarate to succinate ratio (−13.91%), 3-phosphoglycerate to glycerate ratio (15.27%), and Succinate to proline ratio (−14.64%) respectively mediated the total genetic predictive effects of genus Ruminiclostridium 9 on AD risk.ConclusionOur mediation MR analysis provides genetic evidence suggesting the potential mediating role of blood metabolites in the causal relationship between gut microbiota and AD. Further large-scale randomized controlled trials are warranted to validate the role of blood metabolites in the specific mechanisms by which gut microbiota influence AD.

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Causal effects of post-traumatic stress disorder on autoimmune thyroid disease: insights from mendelian randomization

Chen,

Yu,

Yao

et al. 2024

Front. Psychiatry

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ObjectiveThe relationship between post-traumatic stress disorder (PTSD) and autoimmune thyroid disease (AITD) needs further evaluation. This study employs Mendelian randomization (MR) to investigate the causal correlations of PTSD with autoimmune thyroiditis (AIT) and Graves’ disease (GD).MethodsDatasets for PTSD, AIT, and GD were obtained from FinnGen. The exposure-outcome causal relationship was assessed using inverse variance weighted, MR-Egger, and weighted median. Horizontal pleiotropy was evaluated through the MR-Egger intercept, heterogeneity was examined using Cochran’s Q test, and robustness was assessed via leave-one-out sensitivity analysis.ResultsMR analysis indicated no significant causal relationship between PTSD and AIT (OR 0.920, 95% CI 0.832 to 1.017, p = 0.103), but a potential increase in the risk of GD associated with PTSD (OR 1.056, 95% CI 1.008 to 1.105, p = 0.021). MR-Egger intercept showed no horizontal pleiotropy (p > 0.05), and Cochran’s Q showed no heterogeneity (p > 0.05). Sensitivity analysis suggested the MR results were robust.ConclusionsEvidence of an MR association between genetic liability to PTSD and an increased risk of GD were provided, but no evidence of association between PTSD and AIT. The findings indicate that individuals with PTSD may have an increased likelihood of developing GD, underscoring the importance of further research to comprehend the intricate interplay between PTSD and thyroid disorders.

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Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases

Cited by 4 publications

References 125 publications

Vitamin D and allergic diseases

Vitamin D and allergic diseases

Genetic prediction of blood metabolites mediating the relationship between gut microbiota and Alzheimer’s disease: a Mendelian randomization study

Causal effects of post-traumatic stress disorder on autoimmune thyroid disease: insights from mendelian randomization

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